lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Abetalipoproteinemia D000012 7 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with lanosterol

Download all related citations
Per page 10 20 50 100 | Total 1125
Authors Title Published Journal PubMed Link
Saucier SE et al. Accumulation of regulatory oxysterols, 32-oxolanosterol and 32-hydroxylanosterol in mevalonate-treated cell cultures. 1987 J. Biol. Chem. pmid:3654653
Theesfeld CL and Hampton RY Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. 2013 J. Biol. Chem. pmid:23306196
KANDUTSCH AA and RUSSELL AE Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol. 1960 J. Biol. Chem. pmid:14404284
Panini SR et al. Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity. 1989 J. Biol. Chem. pmid:2567731
Lange Y et al. Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. 2008 J. Biol. Chem. pmid:18024962
Dahl JS et al. Effect of cholesterol on macromolecular synthesis and fatty acid uptake by Mycoplasma capricolum. 1981 J. Biol. Chem. pmid:7451451
KANDUTSCH AA and RUSSELL AE Preputial gland tumor sterols. I. The occurrence of 24,25-dihydrolanosterol and a comparison with liver and the normal gland. 1959 J. Biol. Chem. pmid:13673010
GAUTSCHI F and BLOCH K Synthesis of isomeric 4,4-dimethylcholestenols and identification of a lanosterol metabolite. 1958 J. Biol. Chem. pmid:13610839
GAYLOR JL BIOSYNTHESIS OF SKIN STEROLS. VI. ENZYMATIC DEMETHYLATION OF LANOSTEROL AND LANOSTA-7,24-DIEN-3BETA-OL BY HOMOGENATES OF RAT LIVER. 1964 J. Biol. Chem. pmid:14154451
AVIGAN J et al. Studies of cholesterol biosynthesis. IV. Reduction of lanosterol to 24,25-dihydrolanosterol by rat liver homogenates. 1963 J. Biol. Chem. pmid:13965665
CLAYTON RB and BLOCH K Biological synthesis of lanosterol and agnosterol. 1956 J. Biol. Chem. pmid:13278338
Nguyen AD et al. Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. 2007 J. Biol. Chem. pmid:17635920
Megha O et al. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. 2006 J. Biol. Chem. pmid:16735517
BLOCH K et al. Synthesis of lanosterol in vivo. 1957 J. Biol. Chem. pmid:13398396
BLOCH K et al. Isolation of lanosterol from isocholesterol. 1957 J. Biol. Chem. pmid:13398397
Fukushima H et al. Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase. 1981 J. Biol. Chem. pmid:7228857
Kim JH et al. Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression. 2001 J. Biol. Chem. pmid:11279217
Bae SH et al. Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein. 1999 J. Biol. Chem. pmid:10329655
Popják G et al. Inhibition of cholesterol synthesis and cell growth by 24(R,S),25-iminolanosterol and triparanol in cultured rat hepatoma cells. 1989 J. Biol. Chem. pmid:2703486
Taylor FR et al. 24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase. 1986 J. Biol. Chem. pmid:3771561
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
D'Agostino J et al. Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes. 2012 J. Biol. Chem. pmid:22453923
Polito A et al. Artificial substrates in squalene and sterol biosynthesis. 1972 J. Biol. Chem. pmid:4337856
Malhotra HC and Nes WR The conversion of mevalonate to 24-methylenecycloartanol by a cell-free enzyme preparation from nonphotosynthetic tissue. 1972 J. Biol. Chem. pmid:4651646
Favata MF et al. Modulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by azole antimycotics requires lanosterol demethylation, but not 24,25-epoxylanosterol formation. 1987 J. Biol. Chem. pmid:3624255
Trzaskos JM et al. In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. 1987 J. Biol. Chem. pmid:3624256
Milla P et al. Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. 2002 J. Biol. Chem. pmid:11706015
CLAYTON RB and BLOCH K The biological conversion of lanosterol to cholesterol. 1956 J. Biol. Chem. pmid:13278339
Faust J and Krieger M Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant. 1987 J. Biol. Chem. pmid:3643925
Trzaskos JM et al. Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis. 1993 J. Biol. Chem. pmid:7693673
Shi J et al. Identification and characterization of an S-adenosyl-L-methionine: delta 24-sterol-C-methyltransferase cDNA from soybean. 1996 J. Biol. Chem. pmid:8621604
Lange Y and Muraski MF Cholesterol is not synthesized in membranes bearing 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1987 J. Biol. Chem. pmid:3558346
Trzaskos JM et al. Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process. 1986 J. Biol. Chem. pmid:3782148
Villagra A et al. Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. 2007 J. Biol. Chem. pmid:17925399
Lange Y and Muraski MF Topographic heterogeneity in cholesterol biosynthesis. 1988 J. Biol. Chem. pmid:3132462
Nes WD et al. Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase. 1991 J. Biol. Chem. pmid:1869550
OLSON JA et al. On the demethylation of lanosterol to cholesterol. 1957 J. Biol. Chem. pmid:13438883
Aoyama Y et al. Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from yeast evidence confirming the intermediate step of lanosterol 14 alpha-demethylation. 1989 J. Biol. Chem. pmid:2509459
LINDBERG M et al. Ketonic intermediates in the demethylation of lanosterol. 1963 J. Biol. Chem. pmid:13930748
Noland BJ et al. Purification and properties of sterol carrier protein2. 1980 J. Biol. Chem. pmid:7372677
Chang TY et al. Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor. 1979 J. Biol. Chem. pmid:500643
TCHEN TT and BLOCH K On the conversion of squalene to lanosterol in vitro. 1957 J. Biol. Chem. pmid:13438881
Saat YA and Bloch KE Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase. 1976 J. Biol. Chem. pmid:956181
Boesze-Battaglia K et al. Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. 2009 J. Biol. Chem. pmid:19240023
Reinhart MP et al. Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver. 1987 J. Biol. Chem. pmid:3597431
Choi SY et al. Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate. 2010 J. Biomed. Biotechnol. pmid:20300439
Aono T et al. Direct electrochemical analyses of human cytochromes b5 with a mutated heme pocket showed a good correlation between their midpoint and half wave potentials. 2010 J. Biomed. Sci. pmid:21129218
Sheng C et al. Homology modeling of lanosterol 14alpha-demethylase of Candida albicans and Aspergillus fumigatus and insights into the enzyme-substrate Interactions. 2004 J. Biomol. Struct. Dyn. pmid:15214809
Li HJ et al. Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum. 2016 J. Biotechnol. pmid:27080449
Burger BV et al. Mammalian exocrine secretions XVI. Constitutents of secretion of supplementary sacculi of dwarf hamster, Phodopus sungorus sungorus. 2001 J. Chem. Ecol. pmid:11504028