| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Panini SR et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols. | 1986 | J. Lipid Res. | pmid:3559385 |
| Nikkari T et al. | In vivo studies of sterol and squalene secretion by human skin. | 1974 | J. Lipid Res. | pmid:4430879 |
| Gibbons GF et al. | A method for the rapid qualitative and quantitative analysis of 4,4-dimethyl sterols. | 1973 | J. Lipid Res. | pmid:4729975 |
| Ramsey RB and Davison AN | Steryl esters and their relationship to normal and diseased human central nervous system. | 1974 | J. Lipid Res. | pmid:4363969 |
| Hargrove TY et al. | Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design. | 2016 | J. Lipid Res. | pmid:27313059 |
| Bullock E and Dawson CJ | Sterol content of the Myxomycetes Physarum polycephalum and P. flavicomum. | 1976 | J. Lipid Res. | pmid:1033261 |
| Shafiee A et al. | Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates. | 1986 | J. Lipid Res. | pmid:3514778 |
| Aboushadi N and Krisans SK | Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. | 1998 | J. Lipid Res. | pmid:9741690 |
| Izumi A et al. | Inhibitors of sterol synthesis. Submicromolar 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol causes a major modification of the sterol composition of CHO-K1 cells and a marked change in cell morphology. | 1994 | J. Lipid Res. | pmid:7964186 |
| Hucke O et al. | The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease. | 2005 | J. Med. Chem. | pmid:16107140 |
| Pedretti A et al. | Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. | 2002 | J. Med. Chem. | pmid:11906287 |
| Yao B et al. | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. | 2007 | J. Med. Chem. | pmid:17900179 |
| Sheng C et al. | Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. | 2006 | J. Med. Chem. | pmid:16610794 |
| Ji H et al. | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. | 2003 | J. Med. Chem. | pmid:12570370 |
| Lingham RB et al. | Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase. | 1998 | J. Med. Chem. | pmid:9804689 |
| Kraus JM et al. | Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. | 2010 | J. Med. Chem. | pmid:20429511 |
| Suryadevara PK et al. | Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. | 2009 | J. Med. Chem. | pmid:19463001 |
| Rezen T et al. | New aspects on lanosterol 14alpha-demethylase and cytochrome P450 evolution: lanosterol/cycloartenol diversification and lateral transfer. | 2004 | J. Mol. Evol. | pmid:15383907 |
| Cavalier-Smith T and Chao EE | Phylogeny of choanozoa, apusozoa, and other protozoa and early eukaryote megaevolution. | 2003 | J. Mol. Evol. | pmid:12698292 |
| Whitson EL et al. | Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp. | 2008 | J. Nat. Prod. | pmid:18558742 |
| Li H et al. | Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis. | 2008 | J. Nat. Prod. | pmid:18271558 |
| León F et al. | Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells. | 2004 | J. Nat. Prod. | pmid:15620242 |
| Vieira LM et al. | Bioactive friedolanostanes and 11(10-->8)-abeolanostanes from the bark of Garcinia speciosa. | 2004 | J. Nat. Prod. | pmid:15620248 |
| Kuroda M et al. | 27-norlanostane glycosides from the bulbs of Muscari paradoxum. | 2004 | J. Nat. Prod. | pmid:15620262 |
| Akihisa T et al. | Oxygenated lanostane-type triterpenoids from the fungus ganodermalucidum. | 2005 | J. Nat. Prod. | pmid:15844948 |
| Yoshikawa K et al. | Cytotoxic constituents of the fruit body of Daedalea dickisii. | 2005 | J. Nat. Prod. | pmid:15974617 |
| Kerr RG and Chen Z | In vivo and in vitro biosynthesis of saponins in sea cucumbers. | 1995 | J. Nat. Prod. | pmid:7769386 |
| de Silva ED et al. | Lanostane triterpenoids from the Sri Lankan basidiomycete Ganoderma applanatum. | 2006 | J. Nat. Prod. | pmid:16933889 |
| Jayasuriya H et al. | Clavaric acid: a triterpenoid inhibitor of farnesyl-protein transferase from Clavariadelphus truncatus. | 1998 | J. Nat. Prod. | pmid:9868169 |
| Zhao XR et al. | Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and α-Glucosidase. | 2015 | J. Nat. Prod. | pmid:26222905 |
| Rukachaisirikul V et al. | Friedolanostanes and lanostanes from the leaves of Garcinia hombroniana. | 2005 | J. Nat. Prod. | pmid:16124765 |
| Dai HF et al. | Norlanostane triterpenoidal saponins from the marine sponge melophlussarassinorum. | 2005 | J. Nat. Prod. | pmid:16124767 |
| El Dine RS et al. | Anti-HIV-1 protease activity of lanostane triterpenes from the vietnamese mushroom Ganoderma colossum. | 2008 | J. Nat. Prod. | pmid:18547117 |
| González AG et al. | New lanostanoids from the fungus Ganoderma concinna. | 2002 | J. Nat. Prod. | pmid:11908995 |
| Sidjui LS et al. | Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis. | 2017 | J. Nat. Prod. | pmid:28945373 |
| Isaka M et al. | Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. | 2017 | J. Nat. Prod. | pmid:28504879 |
| Wada S et al. | Triterpenoid constituents isolated from the bark of Abies sachalinensis. | 2002 | J. Nat. Prod. | pmid:12444693 |
| Kim KH et al. | Lanostane triterpenoids from the mushroom Naematoloma fasciculare. | 2013 | J. Nat. Prod. | pmid:23634786 |
| Su HJ et al. | New lanostanoids of Ganoderma tsugae. | 2000 | J. Nat. Prod. | pmid:10785428 |
| Isaka M et al. | Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganoderma sp. BCC 16642. | 2016 | J. Nat. Prod. | pmid:26716912 |
| Li G et al. | Endophytic Diaporthe sp. LG23 Produces a Potent Antibacterial Tetracyclic Triterpenoid. | 2015 | J. Nat. Prod. | pmid:26186257 |
| Chen YG et al. | Ananosic acids B and C, two new 18(13-->12)-abeo-lanostane triterpenoids from Kadsura ananosma. | 2004 | J. Nat. Prod. | pmid:15165154 |
| Moodley N et al. | Eucosterol-type nortriterpenoids from Merwilla natalensis. | 2004 | J. Nat. Prod. | pmid:15165167 |
| Liu C et al. | Chemical constituents from Inonotus obliquus and their biological activities. | 2014 | J. Nat. Prod. | pmid:24359303 |
| Cicek SS et al. | Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa. | 2010 | J. Nat. Prod. | pmid:21082802 |
| Akihisa T et al. | Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. | 2009 | J. Nat. Prod. | pmid:19746919 |
| Liaw CC et al. | Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata. | 2013 | J. Nat. Prod. | pmid:23517145 |
| Adams M et al. | Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. | 2010 | J. Nat. Prod. | pmid:20384295 |
| Kamo T et al. | Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus. | 2003 | J. Nat. Prod. | pmid:12932134 |
| Arisawa M et al. | Three new lanostanoids from Ganoderma lucidum. | 1986 Jul-Aug | J. Nat. Prod. | pmid:3783158 |