| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sun S et al. | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15582556 |
| Lu B et al. | Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. | 2007 | Anal. Chim. Acta | pmid:17386793 |
| Büdefeld T et al. | Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes. | 2009 | Anat Histol Embryol | pmid:19793088 |
| Kwok Y et al. | A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. | 2005 | Anesth. Analg. | pmid:16037156 |
| Chen N et al. | Biosynthetic Mechanism of Lanosterol: Cyclization. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26069216 |
| Marco-Jiménez F et al. | Effects of lanosterol on in vitro maturation of porcine oocytes. | 2010 | Anim. Reprod. Sci. | pmid:19473792 |
| Cooper AB et al. | Synthesis and antifungal properties of 14-aminomethyl-substituted lanosterol derivatives. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3214062 |
| Krisans SK | Cell compartmentalization of cholesterol biosynthesis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993542 |
| Gaylor JL and Delwiche CV | Investigation of the multienzymic system of microsomal cholesterol biosynthesis. | 1973 | Ann. N. Y. Acad. Sci. | pmid:4532473 |
| Stocker A | Molecular mechanisms of vitamin E transport. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753133 |
| Barrett-Bee K et al. | Biochemical studies with a novel antifungal agent, ICI 195,739. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3063170 |
| Schroepfer GJ | Sterol biosynthesis. | 1982 | Annu. Rev. Biochem. | pmid:6810750 |
| Ruzicka L | In the borderland between bioorganic chemistry and biochemistry. | 1973 | Annu. Rev. Biochem. | pmid:4600996 |
| Nomura M et al. | Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. | 2008 Sep-Oct | Anticancer Res. | pmid:19035296 |
| Van den Bossche H et al. | In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. | 1980 | Antimicrob. Agents Chemother. | pmid:6250469 |
| Kaneshiro ES et al. | Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. | 2000 | Antimicrob. Agents Chemother. | pmid:10817720 |
| Warrilow AG et al. | Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. | 2013 | Antimicrob. Agents Chemother. | pmid:23274672 |
| Vanden Bossche H et al. | Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. | 1993 | Antimicrob. Agents Chemother. | pmid:8257130 |
| Warrilow AG et al. | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. | 2010 | Antimicrob. Agents Chemother. | pmid:20660663 |
| Sud IJ and Feingold DS | Heterogeneity of action of mechanisms among antimycotic imidazoles. | 1981 | Antimicrob. Agents Chemother. | pmid:6269485 |