| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Theesfeld CL and Hampton RY | Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. | 2013 | J. Biol. Chem. | pmid:23306196 |
| Fan J et al. | Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. | 2013 | New Phytol. | pmid:23442154 |
| Smiljanic K et al. | Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver. | 2013 | Lipids | pmid:24057446 |
| Xie LR et al. | A new cyclonerol derivative from a marine-derived fungus Ascotricha sp. ZJ-M-5. | 2013 | Nat. Prod. Res. | pmid:22840229 |
| Deng JS et al. | Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice. | 2013 | J. Agric. Food Chem. | pmid:23495748 |
| Hu LL et al. | Three new lanostanoid triterpenes from the fruiting bodies of Ganoderma tropicum. | 2013 | J Asian Nat Prod Res | pmid:23421432 |
| Nkanwen ER et al. | Lanostane-type triterpenoid and steroid from the stem bark of Klainedoxa gabonensis. | 2013 | Fitoterapia | pmid:23422226 |
| Xie LR et al. | [A new 3, 4-seco-lanostane triterpenoid from a marine-derived fungus Ascotricha sp. ZJ-M-5]. | 2013 | Yao Xue Xue Bao | pmid:23600147 |
| Kim KH et al. | Lanostane triterpenoids from the mushroom Naematoloma fasciculare. | 2013 | J. Nat. Prod. | pmid:23634786 |
| Warrilow AG et al. | Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. | 2013 | Antimicrob. Agents Chemother. | pmid:23274672 |
| Li B et al. | Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. | 2013 | Food Chem. Toxicol. | pmid:23266269 |
| Susanti D et al. | Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes. | 2013 | Nat. Prod. Res. | pmid:22988818 |
| Sharman JL et al. | IUPHAR-DB: updated database content and new features. | 2013 | Nucleic Acids Res. | pmid:23087376 |
| Cheng S et al. | Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7. | 2013 | Int. J. Oncol. | pmid:23588713 |
| Keber R et al. | Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14α-demethylase (Cyp51). | 2013 | J. Lipid Res. | pmid:23509403 |
| Yajima Y et al. | Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A. | 2013 | Int J Med Mushrooms | pmid:23557369 |
| Lin KW et al. | Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae. | 2013 | Fitoterapia | pmid:23769935 |
| Kolesnikova SA et al. | Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge. | 2013 | J. Nat. Prod. | pmid:23978047 |
| Patkar P et al. | C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications. | 2013 | Biochem. J. | pmid:23984880 |
| BeliÄ A et al. | An algorithm for rapid computational construction of metabolic networks: a cholesterol biosynthesis example. | 2013 | Comput. Biol. Med. | pmid:23566393 |
| Hosogaya N et al. | The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in Candida glabrata. | 2013 | FEMS Yeast Res. | pmid:23496820 |
| Liaw CC et al. | Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata. | 2013 | J. Nat. Prod. | pmid:23517145 |
| Passos GF et al. | The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. | 2013 | Eur. J. Pharmacol. | pmid:23099255 |
| Wang L et al. | Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression. | 2013 | Mol Med Rep | pmid:23969579 |
| Kawashima H et al. | Distribution of unusual cholesterol precursors, 4-methyl- and 4, 4-dimethylsterols with δ8 unsaturation, in gonads of marine archaeogastropods. | 2013 | J Oleo Sci | pmid:23823912 |
| Lange S et al. | Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors. | 2013 | Eur J Med Chem | pmid:23583910 |
| AÄimoviÄ J and Rozman D | Steroidal triterpenes of cholesterol synthesis. | 2013 | Molecules | pmid:23558541 |
| Weeks AC et al. | Identification and potency of cyclodextrin-lipid inhibitors of Staphylococcus aureus α-toxin. | 2012 | Curr. Eye Res. | pmid:22050601 |
| Baardman ME et al. | The origin of fetal sterols in second-trimester amniotic fluid: endogenous synthesis or maternal-fetal transport? | 2012 | Am. J. Obstet. Gynecol. | pmid:22728028 |
| Besga A et al. | Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms. | 2012 | Neurosci. Lett. | pmid:22281444 |
| Shichiri M et al. | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity. | 2012 | J. Biol. Chem. | pmid:22147702 |
| Hooff GP et al. | Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. | 2012 | Mol. Neurobiol. | pmid:22692983 |
| Clark PJ et al. | Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. | 2012 | Hepatology | pmid:22318926 |
| Wang N et al. | Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea. | 2012 | Planta Med. | pmid:22948612 |
| Zhao FQ et al. | [Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4]. | 2012 | Yao Xue Xue Bao | pmid:22812017 |
| Gai YY et al. | Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats. | 2012 | J Ethnopharmacol | pmid:22771280 |
| Parisio G et al. | Flip-flop of steroids in phospholipid bilayers: effects of the chemical structure on transbilayer diffusion. | 2012 | J. Am. Chem. Soc. | pmid:22738146 |
| Howard AL et al. | Sterol C24-methyltransferase: Physio- and stereo-chemical features of the sterol C3 group required for catalytic competence. | 2012 | Arch. Biochem. Biophys. | pmid:22446159 |
| Du YC et al. | Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. | 2012 | Phytomedicine | pmid:22516893 |
| Kořený L et al. | Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22355128 |
| Liu RM et al. | Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitro. | 2012 | Eur. J. Pharmacol. | pmid:22366428 |
| Fakheri RJ and Javitt NB | 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. | 2012 | Steroids | pmid:22366074 |
| Hoshino T et al. | Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring. | 2012 | Chemistry | pmid:22933236 |
| Silbernagel G et al. | Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans. | 2012 | Exp Diabetes Res | pmid:22203835 |
| Vandeputte P et al. | Antifungal resistance and new strategies to control fungal infections. | 2012 | Int J Microbiol | pmid:22187560 |
| Nes CR et al. | Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. | 2012 | Biochem. J. | pmid:22176028 |
| Dutra RC et al. | Euphol prevents experimental autoimmune encephalomyelitis in mice: evidence for the underlying mechanisms. | 2012 | Biochem. Pharmacol. | pmid:22155310 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Lim L et al. | Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. | 2012 | Cell Death Differ. | pmid:21818119 |
| Wang Y et al. | Simultaneous determination of cimicifugoside H-2, cimicifugoside H-1, 23-epi-26-deoxyactein, cimigenol xyloside and 25-O-acetylcimigenoside in beagle dog plasma by LC-MS/MS. | 2012 | J Pharm Biomed Anal | pmid:22285707 |