lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Abetalipoproteinemia D000012 7 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lanosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lanosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with lanosterol

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Authors Title Published Journal PubMed Link
Beach DH et al. Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi epimastigotes. 1986 Biochem. Biophys. Res. Commun. pmid:3521598
Nagai J et al. Effects of thiamine and pyridoxine on the content and composition of sterols in Saccharomyces carlsbergensis 4228. 1974 Biochem. Biophys. Res. Commun. pmid:4418731
Alexander KT et al. A possible role for cytochrome P-450 during the biosynthesis of zymosterol from lanosterol by Saccharomyces cerevisiae. 1974 Biochem. Biophys. Res. Commun. pmid:4609128
Ruf A et al. The monotopic membrane protein human oxidosqualene cyclase is active as monomer. 2004 Biochem. Biophys. Res. Commun. pmid:14766201
Wiss O Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. 1976 Biochem. Biophys. Res. Commun. pmid:1252233
Karst F and Lacroute F Yeast mutant requiring only a sterol as growth supplement. 1974 Biochem. Biophys. Res. Commun. pmid:4601817
Johnson RC and Shah SN Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. 1973 Biochem. Biophys. Res. Commun. pmid:4741538
Cabello-Hurtado F et al. Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14alpha-demethylase (CYP51) in wheat. 1997 Biochem. Biophys. Res. Commun. pmid:9016788
Trocha PJ et al. Novel sterols in ergosterol deficient yeast mutants. 1974 Biochem. Biophys. Res. Commun. pmid:4604829
Ohba M et al. Involvement of cytochrome P-450 and a cyanide-sensitive enzyme in different steps of lanosterol demethylation by yeast microsomes. 1978 Biochem. Biophys. Res. Commun. pmid:369554
Buttke TM and Van Cleave S Adaptation of a cholesterol deficient human T cell line to growth with lanosterol. 1994 Biochem. Biophys. Res. Commun. pmid:8166689
Gollub EG et al. Yeast mutants requiring ergosterol as only lipid supplement. 1974 Biochem. Biophys. Res. Commun. pmid:4363054
Bard M et al. Characterization of a cytochrome P450 deficient mutant of Candida albicans. 1987 Biochem. Biophys. Res. Commun. pmid:3307785
Jiang J et al. Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. 2011 Biochem. Biophys. Res. Commun. pmid:22033405
Aoyama Y and Yoshida Y Interaction of lanosterol to cytochrome P-450 purified from yeast microscomes: evidence for contribution of cytochrome P-450 to lanosterol metabolism. 1978 Biochem. Biophys. Res. Commun. pmid:27189
Aoyama Y and Yoshida Y The 14alpha-demethylation of lanosterol by a reconstituted cytochrome P-450 system from yeast microsomes. 1978 Biochem. Biophys. Res. Commun. pmid:105731
Kimura M et al. Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. 2010 Biochem. Biophys. Res. Commun. pmid:19951700
Jackson CJ et al. Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis. 2003 Biochem. Biophys. Res. Commun. pmid:12565899
M'Baya B and Karst F In vitro assay of squalene epoxidase of Saccharomyces cerevisiae. 1987 Biochem. Biophys. Res. Commun. pmid:3307781
Boutaud O et al. Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. 1995 Biochem. Biophys. Res. Commun. pmid:7887959
Yoshida Y et al. Sterol 14-demethylase P450 activity expressed in rat gonads: contribution to the formation of mammalian meiosis-activating sterol. 1996 Biochem. Biophys. Res. Commun. pmid:8687430
Maitra US et al. Purification of a terminal oxygenase in demethylation of C-30 of lanosterol. 1982 Biochem. Biophys. Res. Commun. pmid:6816234
Baila-Rueda L et al. Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. 2014 Biochem. Biophys. Res. Commun. pmid:24406166
Aoyama Y et al. Buthiobate: a potent inhibitor for yeast cytochrome P-450 catalyzing 14 alpha-demethylation of lanosterol. 1983 Biochem. Biophys. Res. Commun. pmid:6414474
Tabacik C et al. Post-HMG CoA reductase regulation of cholesterol biosynthesis in normal human lymphocytes : lanosten-3 betal-ol-32-al, a natural inhibitor. 1981 Biochem. Biophys. Res. Commun. pmid:7306125
Aoyama Y and Yoshida Y Evidence for the contribution of a sterol 14-reductase to the 14 alpha-demethylation of lanosterol by yeast. 1986 Biochem. Biophys. Res. Commun. pmid:2418830
Gaylor JL Membrane-bound enzymes of cholesterol synthesis from lanosterol. 2002 Biochem. Biophys. Res. Commun. pmid:11969204
Clayton R My years with Konrad, a memoir. 2002 Biochem. Biophys. Res. Commun. pmid:11969210
Nes WD et al. Control of fungal sterol C-24 transalkylation: importance to developmental regulation. 1986 Biochem. Biophys. Res. Commun. pmid:3767970
Yoshida Y et al. Spectral properties of a novel cytochrome P-450 of a Saccharomyces cerevisiae mutant SG1. A cytochrome P-450 species having a nitrogenous ligand trans to thiolate. 1985 Biochem. Biophys. Res. Commun. pmid:3884012
Polo MP and de Bravo MG Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. 2006 Biochem. Cell Biol. pmid:16462894
Tavares IA et al. 4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol. 1977 Biochem. J. pmid:20077
Gibbons FG et al. Studies on the mechanism of lanosterol 14 alpha-demethylation. A requirement for two distinct types of mixed-function-oxidase systems. 1979 Biochem. J. pmid:534498
Akhtar M et al. Chemical and enzymic studies on the characterization of intermediates during the removal of the 14alpha-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives. 1978 Biochem. J. pmid:25646
Iglesias J and Gibbons GF Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol. 1989 Biochem. J. pmid:2604729
Lamb DC et al. Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family. 2002 Biochem. J. pmid:12023899
Smith AG and Goad LJ Sterol biosynthesis in the echinoderm Asterias rubens. 1975 Biochem. J. pmid:1147897
MARCUS S Antibacterial activity of the triterpenoid acid (polyporenic acid C) and of ungulinic acid, metabolic products of Polyporus benzoinus (Wahl.) Fr. 1952 Biochem. J. pmid:14925127
Azrolan NI and Coleman PS A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system. 1989 Biochem. J. pmid:2705993
Hitchcock CA et al. Purification and properties of cytochrome P-450-dependent 14 alpha-sterol demethylase from Candida albicans. 1989 Biochem. J. pmid:2556999
Gibbons GF and Mitropoulos KA Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. 1972 Biochem. J. pmid:5073750
Park JW et al. Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14α-demethylase. 2017 Biochem. J. pmid:28830911
Malvoisin E et al. Relationship between membrane sterol composition and responsiveness to 12-O-tetradecanoylphorbol 13-acetate in HL-60 human promyelocytic leukaemia cell lines. 1988 Biochem. J. pmid:3162674
Bae S et al. Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions. 2001 Biochem. J. pmid:11171067
Beastall GH et al. Studies on phytosterol biosynthesis: metabolism of 24,25-dihydrolanosterol and cholesterol in Ochromonas malhamensis. 1972 Biochem. J. pmid:5085559
Marco de la Calle C et al. A relationship between the activities of hepatic lanosterol 14 alpha-demethylase and 3-hydroxy-3-methylglutaryl-CoA reductase. 1988 Biochem. J. pmid:3355520
Cabrito TR et al. The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. 2011 Biochem. J. pmid:21831043
Tavares IA et al. The pathway for the conversion of dihydroagnosterol into cholesterol in rat liver. 1977 Biochem. J. pmid:901410
Wang CN et al. The inhibition of human platelet function by ganodermic acids. 1991 Biochem. J. pmid:1649599
Derksen A et al. Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo. 1976 Biochem. J. pmid:822845