| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Martirosyan DM et al. | Amaranth oil application for coronary heart disease and hypertension. | 2007 | Lipids Health Dis | pmid:17207282 |
| Machaba KE et al. | In vivo anti-hyperlipidemic activity of the triterpene from the stem bark of Protorhus longifolia (Benrh) Engl. | 2014 | Lipids Health Dis | pmid:25127687 |
| Wong J et al. | Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. | 2007 | Lipids Health Dis | pmid:17408498 |
| Guan SH et al. | Structure elucidation and complete NMR spectral assignments of three new lanostanoid triterpenes with unprecedented Delta(16, 17) double bond from Ganoderma lucidum. | 2007 | Magn Reson Chem | pmid:17640004 |
| D'Souza CA et al. | Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. | 2011 | MBio | pmid:21304167 |
| Vasanthanathan P et al. | Classical QSAR study on chromene derivatives as lanosterol 14alpha- demethylase inhibitor: a non azole antifungal target. | 2006 | Med Chem | pmid:16848747 |
| Stäubert C et al. | Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells. | 2016 | Med. Oncol. | pmid:26698156 |
| De Luca C and Valacchi G | Surface lipids as multifunctional mediators of skin responses to environmental stimuli. | 2010 | Mediators Inflamm. | pmid:20981292 |
| Ottaviani M et al. | Lipid mediators in acne. | 2010 | Mediators Inflamm. | pmid:20871834 |
| Tint GS and Salen G | Evidence for the early reduction of the 24,25 double bond in the conversion of lanosterol to cholesterol in cerebrotendinous xanthomatosis. | 1977 | Metab. Clin. Exp. | pmid:865281 |
| Cuzzopoli M et al. | Effect of nephrectomy and cholesterol feeding on the metabolism of intravenously administered DL-mevalonate in the rat. | 1972 | Metab. Clin. Exp. | pmid:4641957 |
| Gylling H et al. | Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. | 1991 | Metab. Clin. Exp. | pmid:1984567 |
| Lindenthal B and von Bergmann K | Urinary excretion and serum concentration of mevalonic acid during acute intake of alcohol. | 2000 | Metab. Clin. Exp. | pmid:10647065 |
| Clarenbach JJ et al. | Isotopomer spectral analysis of intermediates of cholesterol synthesis in patients with cerebrotendinous xanthomatosis. | 2005 | Metab. Clin. Exp. | pmid:15736111 |
| Zuckermann MJ et al. | Modeling lipid-sterol bilayers: applications to structural evolution, lateral diffusion, and rafts. | 2004 | Meth. Enzymol. | pmid:15063652 |
| Baumann K et al. | Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris. | 2011 | Microb. Cell Fact. | pmid:22050768 |
| Ahmad A et al. | Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. | 2010 | Microb. Pathog. | pmid:19835945 |
| Wang X et al. | Ganoderic acid A inhibits proliferation and invasion, and promotes apoptosis in human hepatocellular carcinoma cells. | 2017 | Mol Med Rep | pmid:28731159 |
| Wang L et al. | Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression. | 2013 | Mol Med Rep | pmid:23969579 |
| Goad LJ et al. | Sterols of ketoconazole-inhibited Leishmania mexicana mexicana promastigotes. | 1985 | Mol. Biochem. Parasitol. | pmid:4033689 |