| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Goad LJ et al. | Sterols of ketoconazole-inhibited Leishmania mexicana mexicana promastigotes. | 1985 | Mol. Biochem. Parasitol. | pmid:4033689 |
| Liendo A et al. | Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes. | 1999 | Mol. Biochem. Parasitol. | pmid:10589983 |
| Buckner FS et al. | Cloning and heterologous expression of the Trypanosoma brucei lanosterol synthase gene. | 2000 | Mol. Biochem. Parasitol. | pmid:11071292 |
| Lamb DC et al. | Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis. | 2007 | Mol. Biol. Evol. | pmid:17567593 |
| Freitas HF et al. | Cloning, expression, purification and spectrophotometric analysis of lanosterol 14-alpha demethylase from Leishmania braziliensis (LbCYP51). | 2018 | Mol. Biol. Rep. | pmid:29363024 |
| Gill BS et al. | Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. | 2016 | Mol. Biol. Rep. | pmid:27640015 |
| Ye X et al. | Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. | 2004 | Mol. Biol. Rep. | pmid:15040456 |
| Ling H et al. | Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells. | 2009 | Mol. Carcinog. | pmid:18973184 |
| Otte K et al. | Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. | 2003 | Mol. Cell. Biol. | pmid:12529392 |
| Jin S et al. | Meiosis activating sterol (MAS) regulate FSH-induced meiotic resumption of cumulus cell-enclosed porcine oocytes via PKC pathway. | 2006 | Mol. Cell. Endocrinol. | pmid:16500744 |
| Xie H et al. | Roles of gonadotropins and meiosis-activating sterols in meiotic resumption of cultured follicle-enclosed mouse oocytes. | 2004 | Mol. Cell. Endocrinol. | pmid:15130520 |
| Lepesheva GI and Waterman MR | CYP51--the omnipotent P450. | 2004 | Mol. Cell. Endocrinol. | pmid:15026190 |
| Rozman D et al. | Pre-cholesterol precursors in gametogenesis. | 2005 | Mol. Cell. Endocrinol. | pmid:15836952 |
| Bokal EV et al. | Follicular sterol composition in gonadotrophin stimulated women with polycystic ovarian syndrome. | 2006 | Mol. Cell. Endocrinol. | pmid:16516374 |
| Rozman D et al. | Lanosterol 14alpha-demethylase and MAS sterols in mammalian gametogenesis. | 2002 | Mol. Cell. Endocrinol. | pmid:11988326 |
| Byskov AG et al. | Role of meiosis activating sterols, MAS, in induced oocyte maturation. | 2002 | Mol. Cell. Endocrinol. | pmid:11988327 |
| Cho SY et al. | Cholesterol biosynthesis from lanosterol: differential inhibition of sterol delta 8-isomerase and other lanosterol-converting enzymes by tamoxifen. | 1998 | Mol. Cells | pmid:9638657 |
| Ning G et al. | 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation. | 2008 | Mol. Endocrinol. | pmid:18467523 |
| Halder SK et al. | A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51). | 2002 | Mol. Endocrinol. | pmid:12145339 |
| Liu Y et al. | Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. | 2005 | Mol. Endocrinol. | pmid:15761033 |