| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ning G et al. | 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation. | 2008 | Mol. Endocrinol. | pmid:18467523 |
| van Nistelrooy JG et al. | Isolation and molecular characterisation of the gene encoding eburicol 14 alpha-demethylase (cYP51) from Penicillium italicum. | 1996 | Mol. Gen. Genet. | pmid:8628233 |
| Kaneshiro ES et al. | The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference. | 2002 | Mol. Microbiol. | pmid:12010494 |
| Hooff GP et al. | Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. | 2012 | Mol. Neurobiol. | pmid:22692983 |
| Zhang H et al. | Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. | 2009 | Mol. Reprod. Dev. | pmid:18937335 |
| Andersen MR et al. | Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger. | 2008 | Mol. Syst. Biol. | pmid:18364712 |
| Spitzer M et al. | Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. | 2011 | Mol. Syst. Biol. | pmid:21694716 |
| Owens CM et al. | Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication. | 2010 | Mol. Syst. Biol. | pmid:20531405 |
| Wang XL et al. | Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi. | 2016 | Molecules | pmid:27775633 |
| Mosa RA et al. | In vivo antihyperglycemic activity of a lanosteryl triterpene from Protorhus longifolia. | 2015 | Molecules | pmid:26205060 |
| Zhang SS et al. | Three new lanostanoids from the mushroom Ganoderma tropicum. | 2015 | Molecules | pmid:25690289 |
| Brycki B et al. | Synthesis, spectroscopic and semiempirical studies of new quaternary alkylammonium conjugates of sterols. | 2013 | Molecules | pmid:24317524 |
| AÄimoviÄ J and Rozman D | Steroidal triterpenes of cholesterol synthesis. | 2013 | Molecules | pmid:23558541 |
| Liu J and Nes WD | Steroidal triterpenes: design of substrate-based inhibitors of ergosterol and sitosterol synthesis. | 2009 | Molecules | pmid:19924096 |
| Franzot SP and Hamdan JS | Effects of three azole derivatives on the lipids of different strains of Cryptococcus neoformans. | 1995 May-Jun | Mycoses | pmid:8531929 |
| Ogbuewu IP et al. | The potentiality of medicinal plants as the source of new contraceptive principles in males. | 2011 | N Am J Med Sci | pmid:22540095 |
| Susanti D et al. | Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes. | 2013 | Nat. Prod. Res. | pmid:22988818 |
| Jamila N et al. | Molecular docking studies and in vitro cholinesterase enzyme inhibitory activities of chemical constituents of Garcinia hombroniana. | 2015 | Nat. Prod. Res. | pmid:25219673 |
| Ruan W et al. | Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. | 2014 | Nat. Prod. Res. | pmid:25032738 |
| Zhang XQ et al. | Triterpenoids with neurotrophic activity from Ganoderma lucidum. | 2011 | Nat. Prod. Res. | pmid:21671206 |