| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shiono Y et al. | N-Phenethylhexadecanamide from the edible mushroom Laetiporus sulphureus. | 2005 | Nat. Prod. Res. | pmid:15938143 |
| Li C et al. | Ganoderic acid Sz, a new lanostanoid from the mushroom Ganoderma lucidum. | 2005 | Nat. Prod. Res. | pmid:15938193 |
| Xie LR et al. | A new cyclonerol derivative from a marine-derived fungus Ascotricha sp. ZJ-M-5. | 2013 | Nat. Prod. Res. | pmid:22840229 |
| Ruan W et al. | Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. | 2014 | Nat. Prod. Res. | pmid:25032738 |
| Zhang XQ et al. | Triterpenoids with neurotrophic activity from Ganoderma lucidum. | 2011 | Nat. Prod. Res. | pmid:21671206 |
| Thoma R et al. | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. | 2004 | Nature | pmid:15525992 |
| DOREE C et al. | Position of the hydroxyl group in lanosterol. | 1949 | Nature | pmid:18107580 |
| Zhao L et al. | Lanosterol reverses protein aggregation in cataracts. | 2015 | Nature | pmid:26200341 |
| Hejtmancik JF | Ophthalmology: Cataracts dissolved. | 2015 | Nature | pmid:26200338 |
| Wang J et al. | Eburicoic acid from Laetiporus sulphureus (Bull.:Fr.) Murrill attenuates inflammatory responses through inhibiting LPS-induced activation of PI3K/Akt/mTOR/NF-κB pathways in RAW264.7 cells. | 2017 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:28577049 |
| van den Kommer TN et al. | The role of extracerebral cholesterol homeostasis and ApoE e4 in cognitive decline. | 2012 | Neurobiol. Aging | pmid:21482441 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Valenza M et al. | Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease. | 2007 | Neurobiol. Dis. | pmid:17702587 |
| Kuehnle K et al. | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. | 2009 | Neurochem. Res. | pmid:19115107 |
| Dutra RC et al. | Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. | 2012 | Neuropharmacology | pmid:22613837 |
| Besga A et al. | Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms. | 2012 | Neurosci. Lett. | pmid:22281444 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Leoni V et al. | Whole body cholesterol metabolism is impaired in Huntington's disease. | 2011 | Neurosci. Lett. | pmid:21406216 |
| Thelen KM et al. | Cholesterol synthesis rate in human hippocampus declines with aging. | 2006 | Neurosci. Lett. | pmid:16701946 |
| Dutra RC et al. | The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε. | 2015 | Neuroscience | pmid:26143011 |