| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Beach DH et al. | Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi epimastigotes. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3521598 |
| Ryder NS et al. | Inhibition of fungal and mammalian sterol biosynthesis by 2-aza-2,3-dihydrosqualene. | 1986 | FEBS Lett. | pmid:3525224 |
| Aoyama Y et al. | Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation. | 1987 | J. Biol. Chem. | pmid:3543000 |
| Lange Y and Muraski MF | Cholesterol is not synthesized in membranes bearing 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1987 | J. Biol. Chem. | pmid:3558346 |
| Panini SR et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols. | 1986 | J. Lipid Res. | pmid:3559385 |
| Pierce AM et al. | Metabolism of delta24-sterols by yeast mutants blocked in removal of the C-14 methyl group. | 1978 | Can. J. Biochem. | pmid:356938 |
| Sonoda Y et al. | A simplified synthesis of 32-oxygenated lanosterol derivatives. | 1987 | Chem. Pharm. Bull. | pmid:3594666 |
| Reinhart MP et al. | Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver. | 1987 | J. Biol. Chem. | pmid:3597431 |
| Favata MF et al. | Modulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by azole antimycotics requires lanosterol demethylation, but not 24,25-epoxylanosterol formation. | 1987 | J. Biol. Chem. | pmid:3624255 |
| Trzaskos JM et al. | In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. | 1987 | J. Biol. Chem. | pmid:3624256 |
| Faust J and Krieger M | Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant. | 1987 | J. Biol. Chem. | pmid:3643925 |
| Tabacik C et al. | Regulation of cholesterol biosynthesis at a stage after the 3-hydroxy-3-methylglutaryl-CoA reductase step, in normal and leukemic (L2C) guinea pig lymphocytes. | 1987 | Biochim. Biophys. Acta | pmid:3651496 |
| Saucier SE et al. | Accumulation of regulatory oxysterols, 32-oxolanosterol and 32-hydroxylanosterol in mevalonate-treated cell cultures. | 1987 | J. Biol. Chem. | pmid:3654653 |
| Ohba M et al. | Involvement of cytochrome P-450 and a cyanide-sensitive enzyme in different steps of lanosterol demethylation by yeast microsomes. | 1978 | Biochem. Biophys. Res. Commun. | pmid:369554 |
| Morisaki M et al. | Inhibitory effect of 15-oxygenated sterols on cholesterol synthesis from 24,25-dihydrolanosterol. | 1986 | J. Biochem. | pmid:3700366 |
| Kraemer FB and Spilman SD | Effects of ketoconazole on cholesterol synthesis. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3746668 |
| Nes WD et al. | Control of fungal sterol C-24 transalkylation: importance to developmental regulation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3767970 |
| Taylor FR et al. | 24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1986 | J. Biol. Chem. | pmid:3771561 |
| Feingold KR et al. | Effect of essential fatty acid deficiency on cutaneous sterol synthesis. | 1986 | J. Invest. Dermatol. | pmid:3772153 |
| Trzaskos JM et al. | Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process. | 1986 | J. Biol. Chem. | pmid:3782148 |