| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Godio RP and MartÃn JF | Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid. | 2009 | Fungal Genet. Biol. | pmid:19130892 |
| Ohyama K et al. | Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19139393 |
| Sugai M et al. | Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside. | 2009 | J Oleo Sci | pmid:19145063 |
| Pezacki JP et al. | Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. | 2009 | BMC Chem Biol | pmid:19149867 |
| Cheng SY et al. | Revision of the absolute configuration at C(23) of lanostanoids and isolation of secondary metabolites from formosan soft coral Nephthea erecta. | 2009 | Chem. Biodivers. | pmid:19180458 |
| Chen CK et al. | Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. | 2009 | PLoS Negl Trop Dis | pmid:19190730 |
| Slominski AT et al. | Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. | 2009 | PLoS ONE | pmid:19190754 |
| Zhang W and Tang YJ | A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides. | 2008 Nov-Dec | Biotechnol. Prog. | pmid:19194938 |
| Langner S et al. | Posaconazole in the management of refractory invasive fungal infections. | 2008 | Ther Clin Risk Manag | pmid:19209257 |
| Boesze-Battaglia K et al. | Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. | 2009 | J. Biol. Chem. | pmid:19240023 |
| Williams MT et al. | Investigation of the rate-determining microsomal reaction of cholesterol biosynthesis from lanosterol in Morris hepatomas and liver. | 1977 | Cancer Res. | pmid:192449 |
| Bozek K et al. | Regulation of clock-controlled genes in mammals. | 2009 | PLoS ONE | pmid:19287494 |
| Kitahama Y et al. | The construction and characterization of self-sufficient lanosterol 14-demethylase fusion proteins consisting of yeast CYP51 and its reductase. | 2009 | Biol. Pharm. Bull. | pmid:19336884 |
| Xu Y et al. | Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. | 2009 | Respir. Res. | pmid:19344509 |
| Chen YJ et al. | Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells. | 2009 | Toxicol In Vitro | pmid:19344682 |
| Ishida K et al. | Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms. | 2009 | BMC Microbiol. | pmid:19379501 |
| Ho YK et al. | Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes. Comparison of cells from normal subjects and patients with homozygous familial hypercholesterolemia and abetalipoproteinemia. | 1977 | J. Exp. Med. | pmid:194011 |
| Tuck SF et al. | Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol. | 1991 | J. Lipid Res. | pmid:1940622 |
| Zhang Q et al. | Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. | 2009 | J Nat Med | pmid:19407927 |
| Sánchez-Wandelmer J et al. | Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes. | 2009 | Biochim. Biophys. Acta | pmid:19433058 |
| Wang C et al. | Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro. | 2009 | J. Lipid Res. | pmid:19433477 |
| Sen K and Hackett JC | Molecular oxygen activation and proton transfer mechanisms in lanosterol 14alpha-demethylase catalysis. | 2009 | J Phys Chem B | pmid:19438188 |
| Lee JH et al. | Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes. | 2009 | Eur. J. Pharmacol. | pmid:19446542 |
| Bean TP et al. | Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides. | 2009 | FEMS Microbiol. Lett. | pmid:19459949 |
| Suryadevara PK et al. | Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. | 2009 | J. Med. Chem. | pmid:19463001 |
| Lee SS et al. | Application of modern NMR techniques in the structure determination of microbial transformation products from sterols. | 1991 | Proc. Natl. Sci. Counc. Repub. China B | pmid:1946817 |
| Marco-Jiménez F et al. | Effects of lanosterol on in vitro maturation of porcine oocytes. | 2010 | Anim. Reprod. Sci. | pmid:19473792 |
| Elfita E et al. | Antiplasmodial and other constituents from four Indonesian Garcinia spp. | 2009 | Phytochemistry | pmid:19481231 |
| Madoui MA et al. | Sterol metabolism in the oomycete Aphanomyces euteiches, a legume root pathogen. | 2009 | New Phytol. | pmid:19496952 |
| Doyle MA et al. | LeishCyc: a biochemical pathways database for Leishmania major. | 2009 | BMC Syst Biol | pmid:19497128 |
| Majid E et al. | Cyclodextrin-modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata. | 2009 | Electrophoresis | pmid:19517437 |
| Lintker KB et al. | A comparison of the packing behavior of egg phosphatidylcholine with cholesterol and biogenically related sterols in Langmuir monolayer films. | 2009 | Chem. Phys. Lipids | pmid:19524563 |
| Acimovic J et al. | Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19525158 |
| Che X et al. | New azoles with potent antifungal activity: design, synthesis and molecular docking. | 2009 | Eur J Med Chem | pmid:19539408 |
| Hashimoto F and Hayashi H | Identification of intermediates after inhibition of cholesterol synthesis by aminotriazole treatment in vivo. | 1991 | Biochim. Biophys. Acta | pmid:1954238 |
| Wang GJ et al. | Lanostanes from Phellinus igniarius and their iNOS inhibitory activities. | 2009 | Planta Med. | pmid:19557671 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Livanec PW et al. | Exploring the effects of sterols in model lipid membranes using single-molecule orientations. | 2009 | J Phys Chem B | pmid:19572622 |
| Chen RY and Yu DQ | [Studies on the triterpenoid constituents of the spores from Ganoderma lucidum karst]. | 1991 | Yao Xue Xue Bao | pmid:1957672 |
| Fernandez-Arche A et al. | Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. | 2010 | Phytomedicine | pmid:19577446 |
| Ma LJ et al. | Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. | 2009 | PLoS Genet. | pmid:19578406 |
| Xu JW et al. | Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19578843 |
| Howard SJ et al. | Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure. | 2009 | Emerging Infect. Dis. | pmid:19624922 |
| Koivusalo AI et al. | Cholesterol, non-cholesterol sterols and bile acids in paediatric gallstones. | 2010 | Dig Liver Dis | pmid:19632165 |
| Liu XT et al. | Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis. | 2010 | Planta Med. | pmid:19644795 |
| Wu J et al. | Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia. | 2009 | BMC Mol. Biol. | pmid:19646271 |
| Singh SD et al. | Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. | 2009 | PLoS Pathog. | pmid:19649312 |
| Brannian J et al. | Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. | 2009 | J Ovarian Res | pmid:19650929 |
| Pires AB et al. | Early development of Moniliophthora perniciosa basidiomata and developmentally regulated genes. | 2009 | BMC Microbiol. | pmid:19653910 |
| Wang CN et al. | The effect of ganodermic acid S on human platelets. | 1990 | Adv. Exp. Med. Biol. | pmid:1966354 |
| Liu J et al. | Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria. | 2010 | Planta Med. | pmid:19670160 |
| de Souza W and Rodrigues JC | Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 | Interdiscip Perspect Infect Dis | pmid:19680554 |
| Wang H et al. | Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing. | 2009 | BMC Microbiol. | pmid:19682357 |
| Ader F et al. | Management of invasive aspergillosis in patients with COPD: rational use of voriconazole. | 2009 | Int J Chron Obstruct Pulmon Dis | pmid:19684861 |
| Cowen LE | Hsp90 orchestrates stress response signaling governing fungal drug resistance. | 2009 | PLoS Pathog. | pmid:19714223 |
| Akihisa T et al. | Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. | 2009 | J. Nat. Prod. | pmid:19746919 |
| Yawata A et al. | Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. | 2009 | Eur J Pharm Sci | pmid:19748575 |
| Wang W et al. | Discovery of highly potent novel antifungal azoles by structure-based rational design. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19748782 |
| Bureau C et al. | Gene array analysis of adrenal glands in broiler chickens following ACTH treatment. | 2009 | BMC Genomics | pmid:19751509 |
| Morris TJ et al. | Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits. | 2009 | PLoS ONE | pmid:19787071 |
| Büdefeld T et al. | Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes. | 2009 | Anat Histol Embryol | pmid:19793088 |
| Dias JR and Gao H | 13C nuclear magnetic resonance data of lanosterol derivatives--profiling the steric topology of the steroid skeleton via substituent effects on its 13C NMR. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19800838 |
| Chen M et al. | A new triterpene from the fruiting bodies of Ganoderma lucidum. | 2009 | Yao Xue Xue Bao | pmid:19806918 |
| Zhang WX et al. | Impact of oxygen level in gaseous phase on gene transcription and ganoderic acid biosynthesis in liquid static cultures of Ganoderma lucidum. | 2010 | Bioprocess Biosyst Eng | pmid:19809834 |
| Tavallaee M and Rad MM | Fixed drug eruption resulting from fluconazole use: a case report. | 2009 | J Med Case Rep | pmid:19830193 |
| Ahmad A et al. | Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. | 2010 | Microb. Pathog. | pmid:19835945 |
| Gylling H et al. | Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. | 1991 | Metab. Clin. Exp. | pmid:1984567 |
| Deng JY et al. | Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas. | 2009 | Chem. Res. Toxicol. | pmid:19848398 |
| Queiroz R et al. | Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons. | 2009 | BMC Genomics | pmid:19857263 |
| Kim JH et al. | Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. | 2010 | J. Neurochem. | pmid:19860851 |
| King AR et al. | Discovery of potent and reversible monoacylglycerol lipase inhibitors. | 2009 | Chem. Biol. | pmid:19875078 |
| Selmecki AM et al. | Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. | 2009 | PLoS Genet. | pmid:19876375 |
| Taramino S et al. | Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast. | 2010 | Biochim. Biophys. Acta | pmid:19879375 |
| Inada A et al. | 24-Ethyl,24-methyl-29-nor-lanostanes from leaves of Freycinetia formosana. | 2009 | Chem. Pharm. Bull. | pmid:19881288 |
| Joffrion TM et al. | Functional characterization and localization of Pneumocystis carinii lanosterol synthase. | 2010 | Eukaryotic Cell | pmid:19897737 |
| Wang W et al. | Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives. | 2009 | Arch. Pharm. (Weinheim) | pmid:19899102 |
| Liu J and Nes WD | Steroidal triterpenes: design of substrate-based inhibitors of ergosterol and sitosterol synthesis. | 2009 | Molecules | pmid:19924096 |
| Adamec J et al. | Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds. | 2009 | J Sep Sci | pmid:19937965 |
| Kimura M et al. | Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19951700 |
| Lütjohann D et al. | 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | 2009 | Int J Clin Pharmacol Ther | pmid:19954708 |
| Aoyama Y et al. | Role of the side chain of lanosterol in substrate recognition and catalytic activity of lanosterol 14 alpha-demethylase (cytochrome P-450 (14DM)) of yeast. | 1991 | Biochim. Biophys. Acta | pmid:1998745 |
| Pérez-Castrillón JL et al. | Vitamin d levels and lipid response to atorvastatin. | 2010 | Int J Endocrinol | pmid:20016682 |
| Zhu J et al. | Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake. | 2010 | J. Lipid Res. | pmid:20037138 |
| Lee I et al. | Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells. | 2010 | J. Nat. Prod. | pmid:20039640 |
| Leszczynska A et al. | Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | 2009 | PLoS ONE | pmid:20041128 |
| Sangamwar AT et al. | Antifungals: need to search for a new molecular target. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046765 |
| Tavares IA et al. | 4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol. | 1977 | Biochem. J. | pmid:20077 |
| Liang CX et al. | Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20077112 |
| Brumfield KM et al. | Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. | 2010 | PLoS ONE | pmid:20084111 |
| Cavalier-Smith T | Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. | 2010 | Biol. Direct | pmid:20132544 |
| Epp E et al. | Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. | 2010 | PLoS Pathog. | pmid:20140196 |
| Sheng C et al. | Improved model of lanosterol 14alpha-demethylase by ligand-supported homology modeling: validation by virtual screening and azole optimization. | 2010 | ChemMedChem | pmid:20157915 |
| Noel JP et al. | Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. | 2010 | ACS Chem. Biol. | pmid:20175559 |
| Wang F et al. | Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol Delta14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20193772 |
| Batova M et al. | Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine). | 2010 | BMC Genomics | pmid:20202201 |
| Fon Tacer K et al. | Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206258 |
| Zhang ZD et al. | Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. | 2010 | Genome Biol. | pmid:20210993 |
| Ponmanickam P et al. | Identification of testosterone-dependent volatile compounds and proteins in the preputial gland of rat Rattus norvegicus. | 2010 | Gen. Comp. Endocrinol. | pmid:20211182 |
| Morio F et al. | Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. | 2010 | Diagn. Microbiol. Infect. Dis. | pmid:20226328 |
| Kölsch H et al. | Alterations of cholesterol precursor levels in Alzheimer's disease. | 2010 | Biochim. Biophys. Acta | pmid:20226877 |