| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takishita K et al. | Lateral transfer of tetrahymanol-synthesizing genes has allowed multiple diverse eukaryote lineages to independently adapt to environments without oxygen. | 2012 | Biol. Direct | pmid:22296756 |
| Warrilow AG et al. | S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole. | 2012 | Antimicrob. Agents Chemother. | pmid:22252802 |
| Yao X et al. | Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. | 2012 | Planta Med. | pmid:22961117 |
| Wang N et al. | Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea. | 2012 | Planta Med. | pmid:22948612 |
| Parisio G et al. | Flip-flop of steroids in phospholipid bilayers: effects of the chemical structure on transbilayer diffusion. | 2012 | J. Am. Chem. Soc. | pmid:22738146 |
| Kirchmair J et al. | Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms. | 2012 | J Chem Inf Model | pmid:22339582 |
| RÃos JL et al. | Lanostanoids from fungi: a group of potential anticancer compounds. | 2012 | J. Nat. Prod. | pmid:23092389 |
| Hoshino T et al. | Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring. | 2012 | Chemistry | pmid:22933236 |
| Kosir R et al. | Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis. | 2012 | PLoS ONE | pmid:22384077 |
| Yun SJ et al. | Aberrant phenotypes of transgenic mice expressing dimeric human erythropoietin. | 2012 | Reprod. Biol. Endocrinol. | pmid:22284751 |
| Cook CC et al. | Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer. | 2012 | Cell Death Dis | pmid:22258408 |
| Shackleton CH | Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesis. | 2012 | Lipids | pmid:21874273 |
| Campbell BC et al. | Chemosensitization as a means to augment commercial antifungal agents. | 2012 | Front Microbiol | pmid:22393330 |
| Liu YT et al. | Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase. | 2012 | Org. Lett. | pmid:23043506 |
| Hargrove TY et al. | Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol. | 2012 | J. Lipid Res. | pmid:22135275 |
| Choi KY et al. | Novel iron-sulfur containing NADPH-reductase from Nocardia farcinica IFM10152 and fusion construction with CYP51 lanosterol demethylase. | 2012 | Biotechnol. Bioeng. | pmid:22038382 |
| Wang JL et al. | Enhanced recovery of antitumor ganoderic acid T from Ganoderma lucidum mycelia by novel chemical conversion strategy. | 2012 | Biotechnol. Bioeng. | pmid:22038732 |
| Barker BM et al. | Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. | 2012 | BMC Genomics | pmid:22309491 |
| Ha do T et al. | In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress. | 2013 | J Ethnopharmacol | pmid:24140584 |
| Ignatenko VA et al. | Direct access to 6/5/7/5- and 6/7/5/5-fused tetracyclic triterpenoids via divergent transannular aldol reaction of lanosterol-derived diketone. | 2013 | J. Org. Chem. | pmid:24161022 |