| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alvarez-Vasquez F et al. | Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. | 2011 | PLoS ONE | pmid:22194828 |
| Alvarez-Rueda N et al. | Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance. | 2011 | PLoS ONE | pmid:21698128 |
| Cantu D et al. | Next generation sequencing provides rapid access to the genome of Puccinia striiformis f. sp. tritici, the causal agent of wheat stripe rust. | 2011 | PLoS ONE | pmid:21909385 |
| Cushion MT et al. | Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. | 2007 | PLoS ONE | pmid:17487271 |
| Vinci G et al. | Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. | 2008 | PLoS ONE | pmid:18682733 |
| Oliaro-Bosso S et al. | Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase. | 2011 | PLoS ONE | pmid:21811565 |
| Ngamskulrungroj P et al. | Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in Cryptococcus neoformans. | 2012 | PLoS ONE | pmid:22412978 |
| Desnos-Ollivier M et al. | Antifungal susceptibility profiles of 1698 yeast reference strains revealing potential emerging human pathogens. | 2012 | PLoS ONE | pmid:22396754 |
| Snelders E et al. | Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. | 2012 | PLoS ONE | pmid:22396740 |
| Kosir R et al. | Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis. | 2012 | PLoS ONE | pmid:22384077 |
| Morris TJ et al. | Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits. | 2009 | PLoS ONE | pmid:19787071 |
| Chadwick W et al. | Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. | 2011 | PLoS ONE | pmid:21738745 |
| Mullins JG et al. | Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola. | 2011 | PLoS ONE | pmid:21738598 |
| Weete JD et al. | Phylogenetic distribution of fungal sterols. | 2010 | PLoS ONE | pmid:20526375 |
| Arendrup MC et al. | Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence. | 2010 | PLoS ONE | pmid:20404915 |
| Solberg R et al. | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. | 2010 | PLoS ONE | pmid:20231903 |
| Chen CL et al. | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. | 2015 | PLoS ONE | pmid:26448474 |
| Walters KA et al. | Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response. | 2006 | PLoS Pathog. | pmid:16789836 |
| Zhang YQ et al. | Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. | 2010 | PLoS Pathog. | pmid:20532216 |
| Semighini CP et al. | Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. | 2011 | PLoS Pathog. | pmid:22114551 |