| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cavalier-Smith T and Chao EE | Phylogeny of choanozoa, apusozoa, and other protozoa and early eukaryote megaevolution. | 2003 | J. Mol. Evol. | pmid:12698292 |
| Hand RA et al. | Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. | 2003 | Eukaryotic Cell | pmid:12684380 |
| Gibbons GF et al. | Lanosterol 14alpha-demethylase. The metabolism of some potential intermediates by cell-free systems from rat liver. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1267815 |
| Schulz-Gasch T and Stahl M | Mechanistic insights into oxidosqualene cyclizations through homology modeling. | 2003 | J Comput Chem | pmid:12666166 |
| Bruneau JM et al. | Drug induced proteome changes in Candida albicans: comparison of the effect of beta(1,3) glucan synthase inhibitors and two triazoles, fluconazole and itraconazole. | 2003 | Proteomics | pmid:12627386 |
| Zhou W et al. | Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii. | 2002 | Lipids | pmid:12617472 |
| Gibbons GF | The role of cytochrome P450 in the regulation of cholesterol biosynthesis. | 2002 | Lipids | pmid:12617470 |
| Rozenberg O et al. | Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615663 |
| Sakurai N et al. | Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. | 2003 | Bioorg. Med. Chem. | pmid:12614901 |
| Yamashita Y et al. | Production of progesterone from de novo-synthesized cholesterol in cumulus cells and its physiological role during meiotic resumption of porcine oocytes. | 2003 | Biol. Reprod. | pmid:12606468 |
| Morales IJ et al. | Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12606318 |
| Kawagishi H et al. | Novel hydroquinone as a matrix metallo-proteinase inhibitor from the mushroom, Piptoporus betulinus. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596882 |
| Luo J and Lin ZB | [A new triterpene from the fruiting bodies of Ganoderma lucidum]. | 2001 | Yao Xue Xue Bao | pmid:12579936 |
| Ji H et al. | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. | 2003 | J. Med. Chem. | pmid:12570370 |
| Jackson CJ et al. | Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565899 |
| Majumder PL et al. | Triterpenoids from the orchids Agrostophyllum brevipes and Agrostophyllum callosum. | 2003 | Phytochemistry | pmid:12560031 |
| Porter TD | Supernatant protein factor and tocopherol-associated protein: an unexpected link between cholesterol synthesis and vitamin E (review). | 2003 | J. Nutr. Biochem. | pmid:12559471 |
| Kaneshiro ES | Sterol biosynthesis in Pneumocystis: unique steps that define unique targets. | 2002 | Drug Resist. Updat. | pmid:12531182 |
| Otte K et al. | Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. | 2003 | Mol. Cell. Biol. | pmid:12529392 |
| Hess BA | Formation of the C ring in the lanosterol biosynthesis from squalene. | 2003 | Org. Lett. | pmid:12529131 |