| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dahl CE et al. | Effects of cycloartenol and lanosterol on artificial and natural membranes. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7356454 |
| Alexander KT et al. | A possible role for cytochrome P-450 during the biosynthesis of zymosterol from lanosterol by Saccharomyces cerevisiae. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4609128 |
| Pinkerton FD et al. | Inhibitors of sterol synthesis. 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol induces changes in the sterol composition and the morphology of CHO-K1 cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3196343 |
| Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
| Gibbons GF et al. | Lanosterol 14alpha-demethylase. The metabolism of some potential intermediates by cell-free systems from rat liver. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1267815 |
| Ohba M et al. | Involvement of cytochrome P-450 and a cyanide-sensitive enzyme in different steps of lanosterol demethylation by yeast microsomes. | 1978 | Biochem. Biophys. Res. Commun. | pmid:369554 |
| Taylor FR and Parks LW | Adaptation of Saccharomyces cerevisiae to growth on cholesterol: selection of mutants defective in the formation of lanosterol. | 1980 | Biochem. Biophys. Res. Commun. | pmid:6998481 |
| Seliskar M et al. | Expression of microsomal lanosterol 14alpha-demethylase (CYP51) in an engineered soluble monomeric form. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18466759 |
| Bard M et al. | Characterization of a cytochrome P450 deficient mutant of Candida albicans. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3307785 |
| Revankar SG et al. | Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474487 |
| Wiss O and Wiss V | The degradation of labelled lanosterol by homogenate of rat liver: evidence for the formation of lithocholic acid from lanosterol without cholesterol as intermediate. | 1978 | Biochem. Biophys. Res. Commun. | pmid:708435 |
| Kushiro M et al. | Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11437378 |
| Buttke TM and Bloch K | Comparative responses of the yeast mutant strain GL7 to lanosterol, cycloartenol, and cyclolaudenol. | 1980 | Biochem. Biophys. Res. Commun. | pmid:6986865 |
| M'Baya B and Karst F | In vitro assay of squalene epoxidase of Saccharomyces cerevisiae. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3307781 |
| Yoshida Y et al. | Sterol 14-demethylase P450 activity expressed in rat gonads: contribution to the formation of mammalian meiosis-activating sterol. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8687430 |
| Ortiz de Montellano PR et al. | Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. | 1979 | Biochem. Biophys. Res. Commun. | pmid:508352 |
| Aoyama Y and Yoshida Y | Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1872829 |
| Aoyama Y and Yoshida Y | Evidence for the contribution of a sterol 14-reductase to the 14 alpha-demethylation of lanosterol by yeast. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2418830 |
| Zhang X and Zhang K | Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes. | 2012 | Biochem Res Int | pmid:22506114 |
| Wyder MA et al. | Clearance in vivo of instilled [h]cholesterol from the rat lung. | 2010 | Biochem Res Int | pmid:21188079 |