| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Honda Y et al. | Revision and confirmation of the regiochemistry of isoxazoles derived from methyl oleanonate and lanost-8-en-3-one. Synthesis of a new lanostane triterpenoid with a cyano-enone functionality in ring A. | 2003 | J. Org. Chem. | pmid:12790619 |
| Porter TD | Supernatant protein factor and tocopherol-associated protein: an unexpected link between cholesterol synthesis and vitamin E (review). | 2003 | J. Nutr. Biochem. | pmid:12559471 |
| Singh DK and Porter TD | Inhibition of sterol 4alpha-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. | 2006 | J. Nutr. | pmid:16484558 |
| Shao MJ and Lei KY | Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. | 1980 | J. Nutr. | pmid:7373433 |
| Tamboli IY et al. | Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. | 2008 | J. Neurosci. | pmid:19005074 |
| KRITCHEVSKY D and DEFENDI V | Deposition of tritium labelled sterols (cholesterol, sitosterol, lanosterol) in brain and other organs of the growing chicken. | 1962 Jul-Aug | J. Neurochem. | pmid:14459731 |
| Dennick RG and Dean PD | Squalene-2(3)-epoxide-lanosterol cyclase in developing rat brain. | 1974 | J. Neurochem. | pmid:4277662 |
| Kim JH et al. | Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. | 2010 | J. Neurochem. | pmid:19860851 |
| Li H et al. | Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis. | 2008 | J. Nat. Prod. | pmid:18271558 |
| Vieira LM et al. | Bioactive friedolanostanes and 11(10-->8)-abeolanostanes from the bark of Garcinia speciosa. | 2004 | J. Nat. Prod. | pmid:15620248 |
| Kuroda M et al. | 27-norlanostane glycosides from the bulbs of Muscari paradoxum. | 2004 | J. Nat. Prod. | pmid:15620262 |
| Yoshikawa K et al. | Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2. | 2005 | J. Nat. Prod. | pmid:15679320 |
| Akihisa T et al. | Oxygenated lanostane-type triterpenoids from the fungus ganodermalucidum. | 2005 | J. Nat. Prod. | pmid:15844948 |
| Yoshikawa K et al. | Cytotoxic constituents of the fruit body of Daedalea dickisii. | 2005 | J. Nat. Prod. | pmid:15974617 |
| Kerr RG and Chen Z | In vivo and in vitro biosynthesis of saponins in sea cucumbers. | 1995 | J. Nat. Prod. | pmid:7769386 |
| Shin BA et al. | Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis. | 1999 | J. Nat. Prod. | pmid:10579872 |
| Zhao XR et al. | Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and α-Glucosidase. | 2015 | J. Nat. Prod. | pmid:26222905 |
| Rukachaisirikul V et al. | Friedolanostanes and lanostanes from the leaves of Garcinia hombroniana. | 2005 | J. Nat. Prod. | pmid:16124765 |
| Dai HF et al. | Norlanostane triterpenoidal saponins from the marine sponge melophlussarassinorum. | 2005 | J. Nat. Prod. | pmid:16124767 |
| El Dine RS et al. | Anti-HIV-1 protease activity of lanostane triterpenes from the vietnamese mushroom Ganoderma colossum. | 2008 | J. Nat. Prod. | pmid:18547117 |
| Wang N et al. | Lanostane-type triterpenoids from the roots of Kadsura coccinea. | 2008 | J. Nat. Prod. | pmid:18491866 |
| González AG et al. | New lanostanoids from the fungus Ganoderma concinna. | 2002 | J. Nat. Prod. | pmid:11908995 |
| Ma J et al. | New lanostanoids from the mushroom Ganoderma lucidum. | 2002 | J. Nat. Prod. | pmid:11809071 |
| Su HJ et al. | Lanostanoids of Amentotaxus formosana. | 2002 | J. Nat. Prod. | pmid:11809073 |
| Ukiya M et al. | Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos. | 2002 | J. Nat. Prod. | pmid:11975480 |
| Yoshikawa K et al. | New lanostanoids, elfvingic acids A-H, from the fruit body of Elfvingia applanata. | 2002 | J. Nat. Prod. | pmid:11975498 |
| Sidjui LS et al. | Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis. | 2017 | J. Nat. Prod. | pmid:28945373 |
| Isaka M et al. | Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. | 2017 | J. Nat. Prod. | pmid:28504879 |
| Wada S et al. | Triterpenoid constituents isolated from the bark of Abies sachalinensis. | 2002 | J. Nat. Prod. | pmid:12444693 |
| Kim KH et al. | Lanostane triterpenoids from the mushroom Naematoloma fasciculare. | 2013 | J. Nat. Prod. | pmid:23634786 |
| Lai KH et al. | Cytotoxic Lanostanoids from Poria cocos. | 2016 | J. Nat. Prod. | pmid:27808511 |
| Hu ZX et al. | Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea. | 2016 | J. Nat. Prod. | pmid:27704807 |
| RÃos JL et al. | Lanostanoids from fungi: a group of potential anticancer compounds. | 2012 | J. Nat. Prod. | pmid:23092389 |
| Kwon J et al. | Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis. | 2016 | J. Nat. Prod. | pmid:27266877 |
| Su HJ et al. | New lanostanoids of Ganoderma tsugae. | 2000 | J. Nat. Prod. | pmid:10785428 |
| Kolesnikova SA et al. | Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge. | 2013 | J. Nat. Prod. | pmid:23978047 |
| Li G et al. | Endophytic Diaporthe sp. LG23 Produces a Potent Antibacterial Tetracyclic Triterpenoid. | 2015 | J. Nat. Prod. | pmid:26186257 |
| Chen YG et al. | Ananosic acids B and C, two new 18(13-->12)-abeo-lanostane triterpenoids from Kadsura ananosma. | 2004 | J. Nat. Prod. | pmid:15165154 |
| Moodley N et al. | Eucosterol-type nortriterpenoids from Merwilla natalensis. | 2004 | J. Nat. Prod. | pmid:15165167 |
| Peng XR et al. | Hepatoprotective effects of triterpenoids from Ganoderma cochlear. | 2014 | J. Nat. Prod. | pmid:24559087 |
| Liu C et al. | Chemical constituents from Inonotus obliquus and their biological activities. | 2014 | J. Nat. Prod. | pmid:24359303 |
| Shim SH et al. | New lanostane-type triterpenoids from Ganoderma applanatum. | 2004 | J. Nat. Prod. | pmid:15270562 |
| Cicek SS et al. | Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa. | 2010 | J. Nat. Prod. | pmid:21082802 |
| Akihisa T et al. | Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. | 2009 | J. Nat. Prod. | pmid:19746919 |
| Stanikunaite R et al. | Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity. | 2008 | J. Nat. Prod. | pmid:19067555 |
| Liaw CC et al. | Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata. | 2013 | J. Nat. Prod. | pmid:23517145 |
| Adams M et al. | Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. | 2010 | J. Nat. Prod. | pmid:20384295 |
| Lee I et al. | Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells. | 2010 | J. Nat. Prod. | pmid:20039640 |
| Kennedy EM et al. | Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols. | 2011 | J. Nat. Prod. | pmid:22044278 |
| Arisawa M et al. | Three new lanostanoids from Ganoderma lucidum. | 1986 Jul-Aug | J. Nat. Prod. | pmid:3783158 |