| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang F et al. | Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol Delta14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20193772 |
| Sun C et al. | De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. | 2010 | BMC Genomics | pmid:20416102 |
| Sheng C et al. | Improved model of lanosterol 14alpha-demethylase by ligand-supported homology modeling: validation by virtual screening and azole optimization. | 2010 | ChemMedChem | pmid:20157915 |
| Kimura M et al. | Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19951700 |
| De Luca C and Valacchi G | Surface lipids as multifunctional mediators of skin responses to environmental stimuli. | 2010 | Mediators Inflamm. | pmid:20981292 |
| Brockington A et al. | Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis. | 2010 | BMC Genomics | pmid:20346106 |
| Handa N et al. | An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus. | 2010 | Phytochemistry | pmid:20691456 |
| Zoller E et al. | Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections. | 2010 | Drug Des Devel Ther | pmid:21116336 |
| Goldstone JV et al. | Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. | 2010 | BMC Genomics | pmid:21087487 |
| Arendrup MC et al. | Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence. | 2010 | PLoS ONE | pmid:20404915 |
| Chen CK et al. | Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. | 2010 | PLoS Negl Trop Dis | pmid:20386598 |
| Choi SY et al. | Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate. | 2010 | J. Biomed. Biotechnol. | pmid:20300439 |
| Fon Tacer K et al. | Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206258 |
| Xu Y et al. | Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. | 2009 | Respir. Res. | pmid:19344509 |
| Kitahama Y et al. | The construction and characterization of self-sufficient lanosterol 14-demethylase fusion proteins consisting of yeast CYP51 and its reductase. | 2009 | Biol. Pharm. Bull. | pmid:19336884 |
| Brannian J et al. | Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. | 2009 | J Ovarian Res | pmid:19650929 |
| Wang W et al. | Discovery of highly potent novel antifungal azoles by structure-based rational design. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19748782 |
| Livanec PW et al. | Exploring the effects of sterols in model lipid membranes using single-molecule orientations. | 2009 | J Phys Chem B | pmid:19572622 |
| Che X et al. | New azoles with potent antifungal activity: design, synthesis and molecular docking. | 2009 | Eur J Med Chem | pmid:19539408 |
| Godio RP and MartÃn JF | Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid. | 2009 | Fungal Genet. Biol. | pmid:19130892 |
| Sen K and Hackett JC | Molecular oxygen activation and proton transfer mechanisms in lanosterol 14alpha-demethylase catalysis. | 2009 | J Phys Chem B | pmid:19438188 |
| Lintker KB et al. | A comparison of the packing behavior of egg phosphatidylcholine with cholesterol and biogenically related sterols in Langmuir monolayer films. | 2009 | Chem. Phys. Lipids | pmid:19524563 |
| Bozek K et al. | Regulation of clock-controlled genes in mammals. | 2009 | PLoS ONE | pmid:19287494 |
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| Büdefeld T et al. | Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes. | 2009 | Anat Histol Embryol | pmid:19793088 |
| Nes WD et al. | Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. | 2009 | Arch. Biochem. Biophys. | pmid:19014901 |
| Cheng SY et al. | Revision of the absolute configuration at C(23) of lanostanoids and isolation of secondary metabolites from formosan soft coral Nephthea erecta. | 2009 | Chem. Biodivers. | pmid:19180458 |
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| Inada A et al. | 24-Ethyl,24-methyl-29-nor-lanostanes from leaves of Freycinetia formosana. | 2009 | Chem. Pharm. Bull. | pmid:19881288 |
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| Dias JR and Gao H | 13C nuclear magnetic resonance data of lanosterol derivatives--profiling the steric topology of the steroid skeleton via substituent effects on its 13C NMR. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19800838 |
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| Wu J et al. | Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia. | 2009 | BMC Mol. Biol. | pmid:19646271 |
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| Boesze-Battaglia K et al. | Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. | 2009 | J. Biol. Chem. | pmid:19240023 |
| Suryadevara PK et al. | Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. | 2009 | J. Med. Chem. | pmid:19463001 |
| Wang C et al. | Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro. | 2009 | J. Lipid Res. | pmid:19433477 |