MeSH term | MeSH ID | Detail |
---|---|---|
Xanthomatosis | D014973 | 17 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Xanthomatosis | D014973 | 17 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sud IJ and Feingold DS | Mechanisms of action of the antimycotic imidazoles. | 1981 | J. Invest. Dermatol. | pmid:7017013 |
Patouraux D et al. | Detection and quantification of lanosterol and dihydrolanosterol esters by measurements of metastable decompositions. Application to their direct analysis in wool wax. | 1981 | Biomed. Mass Spectrom. | pmid:6894557 |
Dahl JS et al. | Effect of cholesterol on macromolecular synthesis and fatty acid uptake by Mycoplasma capricolum. | 1981 | J. Biol. Chem. | pmid:7451451 |
Fukushima H et al. | Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase. | 1981 | J. Biol. Chem. | pmid:7228857 |
Schick BP and Schick PK | Cholesterol and phospholipid biosynthesis in guinea pig megakaryocytes. | 1981 | Biochim. Biophys. Acta | pmid:7011413 |
Hemmi H | Differential cytotoxicity of cytosine arabinoside toward murine leukemia L1210 cells and murine bone marrow progenitor cells inhibited in nucleoside transport by cimicifugoside. | 1981 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6791252 |
Tabacik C et al. | Post-HMG CoA reductase regulation of cholesterol biosynthesis in normal human lymphocytes : lanosten-3 betal-ol-32-al, a natural inhibitor. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7306125 |
Sud IJ and Feingold DS | Heterogeneity of action of mechanisms among antimycotic imidazoles. | 1981 | Antimicrob. Agents Chemother. | pmid:6269485 |
Hemmi H et al. | Selective inhibition of nucleoside transport into mouse lymphoma L-5178Y cells by cimicfugoside. | 1980 | J. Pharmacobio-dyn. | pmid:7277178 |
Hemmi H and Ishida N | The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. | 1980 | J. Pharmacobio-dyn. | pmid:7277179 |