lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Xanthomatosis D014973 17 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with lanosterol

Download all related citations
Per page 10 20 50 100 | Total 1125
Authors Title Published Journal PubMed Link
Cavalier-Smith T Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. 2010 Biol. Direct pmid:20132544
Koivusalo AI et al. Cholesterol, non-cholesterol sterols and bile acids in paediatric gallstones. 2010 Dig Liver Dis pmid:19632165
Noel JP et al. Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. 2010 ACS Chem. Biol. pmid:20175559
Xu JW et al. Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. 2010 Appl. Microbiol. Biotechnol. pmid:19578843
Liu XT et al. Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis. 2010 Planta Med. pmid:19644795
Liu J et al. Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria. 2010 Planta Med. pmid:19670160
LaFayette SL et al. PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. 2010 PLoS Pathog. pmid:20865172
Ferreira C et al. Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p. 2010 BMC Microbiol. pmid:20843317
Fernandez-Arche A et al. Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. 2010 Phytomedicine pmid:19577446
Iskar M et al. Drug-induced regulation of target expression. 2010 PLoS Comput. Biol. pmid:20838579
Batova M et al. Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine). 2010 BMC Genomics pmid:20202201
Epp E et al. Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. 2010 PLoS Pathog. pmid:20140196
Ahmad A et al. Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. 2010 Microb. Pathog. pmid:19835945
Xu Y et al. Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. 2009 Respir. Res. pmid:19344509
Kitahama Y et al. The construction and characterization of self-sufficient lanosterol 14-demethylase fusion proteins consisting of yeast CYP51 and its reductase. 2009 Biol. Pharm. Bull. pmid:19336884
Pezacki JP et al. Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. 2009 BMC Chem Biol pmid:19149867
Livanec PW et al. Exploring the effects of sterols in model lipid membranes using single-molecule orientations. 2009 J Phys Chem B pmid:19572622
Che X et al. New azoles with potent antifungal activity: design, synthesis and molecular docking. 2009 Eur J Med Chem pmid:19539408
Godio RP and Martín JF Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid. 2009 Fungal Genet. Biol. pmid:19130892
Sen K and Hackett JC Molecular oxygen activation and proton transfer mechanisms in lanosterol 14alpha-demethylase catalysis. 2009 J Phys Chem B pmid:19438188
Sugai M et al. Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside. 2009 J Oleo Sci pmid:19145063
Chen CK et al. Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. 2009 PLoS Negl Trop Dis pmid:19190730
Bozek K et al. Regulation of clock-controlled genes in mammals. 2009 PLoS ONE pmid:19287494
Sánchez-Wandelmer J et al. Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes. 2009 Biochim. Biophys. Acta pmid:19433058
Slominski AT et al. Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. 2009 PLoS ONE pmid:19190754
Leszczynska A et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. 2009 PLoS ONE pmid:20041128
Nes WD et al. Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. 2009 Arch. Biochem. Biophys. pmid:19014901
Cheng SY et al. Revision of the absolute configuration at C(23) of lanostanoids and isolation of secondary metabolites from formosan soft coral Nephthea erecta. 2009 Chem. Biodivers. pmid:19180458
Zhang H et al. Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. 2009 Mol. Reprod. Dev. pmid:18937335
Sun LM et al. The effect of plagiochin E alone and in combination with fluconazole on the ergosterol biosynthesis of Candida albicans. 2009 Biol. Pharm. Bull. pmid:19122277
Ling H et al. Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells. 2009 Mol. Carcinog. pmid:18973184
Chen YJ et al. Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells. 2009 Toxicol In Vitro pmid:19344682
Acimovic J et al. Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19525158
Madoui MA et al. Sterol metabolism in the oomycete Aphanomyces euteiches, a legume root pathogen. 2009 New Phytol. pmid:19496952
Solomon A et al. Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. 2009 Neurosci. Lett. pmid:19560513
Zhang Q et al. Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. 2009 J Nat Med pmid:19407927
Ishida K et al. Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms. 2009 BMC Microbiol. pmid:19379501
Ankam R et al. Simultaneous HPLC determination of butenafine hydrochloride and betamethasone in a cream formulation. 2009 Indian J Pharm Sci pmid:20502575
Inada A et al. 24-Ethyl,24-methyl-29-nor-lanostanes from leaves of Freycinetia formosana. 2009 Chem. Pharm. Bull. pmid:19881288
Adamec J et al. Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds. 2009 J Sep Sci pmid:19937965
Dias JR and Gao H 13C nuclear magnetic resonance data of lanosterol derivatives--profiling the steric topology of the steroid skeleton via substituent effects on its 13C NMR. 2009 Spectrochim Acta A Mol Biomol Spectrosc pmid:19800838
Chen M et al. A new triterpene from the fruiting bodies of Ganoderma lucidum. 2009 Yao Xue Xue Bao pmid:19806918
King AR et al. Discovery of potent and reversible monoacylglycerol lipase inhibitors. 2009 Chem. Biol. pmid:19875078
Selmecki AM et al. Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. 2009 PLoS Genet. pmid:19876375
Queiroz R et al. Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons. 2009 BMC Genomics pmid:19857263
Liu J and Nes WD Steroidal triterpenes: design of substrate-based inhibitors of ergosterol and sitosterol synthesis. 2009 Molecules pmid:19924096
Doyle MA et al. LeishCyc: a biochemical pathways database for Leishmania major. 2009 BMC Syst Biol pmid:19497128
Boesze-Battaglia K et al. Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. 2009 J. Biol. Chem. pmid:19240023
Suryadevara PK et al. Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. 2009 J. Med. Chem. pmid:19463001
Wang C et al. Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro. 2009 J. Lipid Res. pmid:19433477