| MeSH term | MeSH ID | Detail |
|---|---|---|
| Xanthomatosis | D014973 | 17 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Krueger KP and Nelson AC | Economic considerations in the treatment of invasive aspergillosis: a review of voriconazole pharmacoeconomic studies. | 2009 | Clinicoecon Outcomes Res | pmid:21935305 |
| Desmond E and Gribaldo S | Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature. | 2009 | Genome Biol Evol | pmid:20333205 |
| Brannian J et al. | Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. | 2009 | J Ovarian Res | pmid:19650929 |
| Wang W et al. | Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives. | 2009 | Arch. Pharm. (Weinheim) | pmid:19899102 |
| Wang W et al. | Discovery of highly potent novel antifungal azoles by structure-based rational design. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19748782 |
| Bureau C et al. | Gene array analysis of adrenal glands in broiler chickens following ACTH treatment. | 2009 | BMC Genomics | pmid:19751509 |
| Lintker KB et al. | A comparison of the packing behavior of egg phosphatidylcholine with cholesterol and biogenically related sterols in Langmuir monolayer films. | 2009 | Chem. Phys. Lipids | pmid:19524563 |
| Lütjohann D et al. | 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | 2009 | Int J Clin Pharmacol Ther | pmid:19954708 |
| de Souza W and Rodrigues JC | Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 | Interdiscip Perspect Infect Dis | pmid:19680554 |
| Büdefeld T et al. | Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes. | 2009 | Anat Histol Embryol | pmid:19793088 |
| Monostory K et al. | Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent. | 2009 | Drug Metab. Dispos. | pmid:18971317 |
| Morris TJ et al. | Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits. | 2009 | PLoS ONE | pmid:19787071 |
| Ohyama K et al. | Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19139393 |
| Akihisa T et al. | Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. | 2009 | J. Nat. Prod. | pmid:19746919 |
| Yawata A et al. | Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. | 2009 | Eur J Pharm Sci | pmid:19748575 |
| Tang YJ et al. | Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. | 2009 | Bioresour. Technol. | pmid:19010665 |
| Lee JH et al. | Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes. | 2009 | Eur. J. Pharmacol. | pmid:19446542 |
| Bean TP et al. | Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides. | 2009 | FEMS Microbiol. Lett. | pmid:19459949 |
| Majid E et al. | Cyclodextrin-modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata. | 2009 | Electrophoresis | pmid:19517437 |
| Deng JY et al. | Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas. | 2009 | Chem. Res. Toxicol. | pmid:19848398 |
| Elfita E et al. | Antiplasmodial and other constituents from four Indonesian Garcinia spp. | 2009 | Phytochemistry | pmid:19481231 |
| Wang GJ et al. | Lanostanes from Phellinus igniarius and their iNOS inhibitory activities. | 2009 | Planta Med. | pmid:19557671 |
| Tavallaee M and Rad MM | Fixed drug eruption resulting from fluconazole use: a case report. | 2009 | J Med Case Rep | pmid:19830193 |
| Cowen LE | Hsp90 orchestrates stress response signaling governing fungal drug resistance. | 2009 | PLoS Pathog. | pmid:19714223 |
| Ader F et al. | Management of invasive aspergillosis in patients with COPD: rational use of voriconazole. | 2009 | Int J Chron Obstruct Pulmon Dis | pmid:19684861 |
| Wang H et al. | Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing. | 2009 | BMC Microbiol. | pmid:19682357 |
| Kuehnle K et al. | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. | 2009 | Neurochem. Res. | pmid:19115107 |
| Pires AB et al. | Early development of Moniliophthora perniciosa basidiomata and developmentally regulated genes. | 2009 | BMC Microbiol. | pmid:19653910 |
| Singh SD et al. | Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. | 2009 | PLoS Pathog. | pmid:19649312 |
| Wu J et al. | Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia. | 2009 | BMC Mol. Biol. | pmid:19646271 |
| Howard SJ et al. | Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure. | 2009 | Emerging Infect. Dis. | pmid:19624922 |
| Ma LJ et al. | Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. | 2009 | PLoS Genet. | pmid:19578406 |
| Nomura M et al. | Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. | 2008 Sep-Oct | Anticancer Res. | pmid:19035296 |
| Zhang W and Tang YJ | A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides. | 2008 Nov-Dec | Biotechnol. Prog. | pmid:19194938 |
| Sangamwar AT et al. | Antifungals: need to search for a new molecular target. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046765 |
| Langner S et al. | Posaconazole in the management of refractory invasive fungal infections. | 2008 | Ther Clin Risk Manag | pmid:19209257 |
| Li X et al. | Multiple effects of a novel compound from Burkholderia cepacia against Candida albicans. | 2008 | FEMS Microbiol. Lett. | pmid:18565124 |
| Whitson EL et al. | Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp. | 2008 | J. Nat. Prod. | pmid:18558742 |
| Li H et al. | Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis. | 2008 | J. Nat. Prod. | pmid:18271558 |
| Xu B et al. | Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA. | 2008 | Biol. Pharm. Bull. | pmid:18520052 |
| Jiang J et al. | Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. | 2008 | Int. J. Mol. Med. | pmid:18425349 |
| Ning G et al. | 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation. | 2008 | Mol. Endocrinol. | pmid:18467523 |
| Gao HY et al. | Novel lanostane and rearranged lanostane-type triterpenoids from Abies sachalinensis - II -. | 2008 | Chem. Pharm. Bull. | pmid:18379107 |
| Mueller AM et al. | Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. | 2008 | J Neuroinflammation | pmid:18501024 |
| Andersen MR et al. | Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger. | 2008 | Mol. Syst. Biol. | pmid:18364712 |
| Song X et al. | Expression and regulation of lanosterol 14alpha-demethylase in mouse embryo and uterus during the peri-implantation period. | 2008 | Reprod. Fertil. Dev. | pmid:19007561 |
| Wu TK et al. | Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions. | 2008 | Org. Lett. | pmid:18842050 |
| de Sain-van der Velden MG et al. | Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. | 2008 | J. Inherit. Metab. Dis. | pmid:18949577 |
| Sabatini K et al. | Interfacial behavior of cholesterol, ergosterol, and lanosterol in mixtures with DPPC and DMPC. | 2008 | Biophys. J. | pmid:18515391 |
| Fassbender K et al. | Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. | 2008 | Atherosclerosis | pmid:17137582 |