MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Chong CR et al. | Inhibition of angiogenesis by the antifungal drug itraconazole. | 2007 | ACS Chem. Biol. | pmid:17432820 |
Noel JP et al. | Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. | 2010 | ACS Chem. Biol. | pmid:20175559 |
Wang N et al. | N-Cyclo-propyl-N-[2-(2,4-difluoro-phen-yl)-2-hy-droxy-1-(1H-1,2,4-triazol-1-yl)prop-yl]-2-(5-methyl-2,4-dioxo-1,2,3,4-tetra-hydro-pyrimidin-1-yl)acetamide dichloro-methane 0.62-solvate. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22059025 |
de la Torre B et al. | Pathways of testosterone synthesis in decapsulated testes of mice. | 1976 | Acta Endocrinol. | pmid:128970 |
Edgren B and Hellström K | Lipid biosynthesis from DL (2- 14 C) mevalonic acid in intact mice and rabbits. | 1972 | Acta Physiol. Scand. | pmid:4640173 |
Wang CN et al. | The effect of ganodermic acid S on human platelets. | 1990 | Adv. Exp. Med. Biol. | pmid:1966354 |
Herman GE and Kratz L | Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome. | 2012 | Am J Med Genet C Semin Med Genet | pmid:23042573 |
Leichtle AB et al. | Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men. | 2011 | Am. J. Clin. Nutr. | pmid:21940598 |
Abuelo DN et al. | Prenatal detection of the cholesterol biosynthetic defect in the Smith-Lemli-Opitz syndrome by the analysis of amniotic fluid sterols. | 1995 | Am. J. Med. Genet. | pmid:7778590 |
Andersson HC et al. | Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. | 2002 | Am. J. Med. Genet. | pmid:12457401 |
Kelley RI et al. | Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia. | 2002 | Am. J. Med. Genet. | pmid:12116245 |
Cragun DL et al. | Undetectable maternal serum uE3 and postnatal abnormal sterol and steroid metabolism in Antley-Bixler syndrome. | 2004 | Am. J. Med. Genet. A | pmid:15266606 |
Adachi M et al. | Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome. | 2004 | Am. J. Med. Genet. A | pmid:15264278 |
Baardman ME et al. | The origin of fetal sterols in second-trimester amniotic fluid: endogenous synthesis or maternal-fetal transport? | 2012 | Am. J. Obstet. Gynecol. | pmid:22728028 |
Cai SY et al. | The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17567710 |
Pietila MP et al. | Cloning and characterization of CYP51 from Mycobacterium avium. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16543605 |
Morales IJ et al. | Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12606318 |
Domeño C et al. | Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID. | 2005 | Anal Bioanal Chem | pmid:15827725 |
Sun S et al. | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15582556 |