lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with lanosterol

Download all related citations
Per page 10 20 50 100 | Total 1125
Authors Title Published Journal PubMed Link
Bizerra FC et al. Characteristics of biofilm formation by Candida tropicalis and antifungal resistance. 2008 FEMS Yeast Res. pmid:18248413
Mantzouridou F and Tsimidou MZ Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. 2010 FEMS Yeast Res. pmid:20550581
Veen M et al. Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. 2003 FEMS Yeast Res. pmid:14554200
Kushima H et al. Cloning of the lanosterol 14-α-demethylase ( ERG11 ) gene in Trichosporon asahii: a possible association between G453R amino acid substitution and azole resistance in T. asahii. 2012 FEMS Yeast Res. pmid:22621704
Kim D et al. Functional expression and characterization of CYP51 from dandruff-causing Malassezia globosa. 2011 FEMS Yeast Res. pmid:21114623
Tian Z et al. Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida. 2006 Fitoterapia pmid:16300906
Nkanwen ER et al. Lanostane-type triterpenoid and steroid from the stem bark of Klainedoxa gabonensis. 2013 Fitoterapia pmid:23422226
Sakamoto S et al. Immunochromatographic strip assay for detection of bioactive Ganoderma triterpenoid, ganoderic acid A in Ganoderma lingzhi. 2016 Fitoterapia pmid:27575328
Qiu J et al. Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum. 2016 Fitoterapia pmid:26709153
Lin KW et al. Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae. 2013 Fitoterapia pmid:23769935
Huang GJ et al. Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury. 2013 Food Chem pmid:23871054
Li B et al. Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. 2013 Food Chem. Toxicol. pmid:23266269
Lin MW et al. Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. 2012 Food Chem. Toxicol. pmid:22634261
Campbell BC et al. Chemosensitization as a means to augment commercial antifungal agents. 2012 Front Microbiol pmid:22393330
Sawai S and Saito K Triterpenoid biosynthesis and engineering in plants. 2011 Front Plant Sci pmid:22639586
Godio RP and Martín JF Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid. 2009 Fungal Genet. Biol. pmid:19130892
Uthman A et al. Fluconazole upregulates sconC expression and inhibits sulphur metabolism in Microsporum canis. 2005 Fungal Genet. Biol. pmid:15922636
Ponmanickam P et al. Identification of testosterone-dependent volatile compounds and proteins in the preputial gland of rat Rattus norvegicus. 2010 Gen. Comp. Endocrinol. pmid:20211182
Desmond E and Gribaldo S Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature. 2009 Genome Biol Evol pmid:20333205
Maurer-Stroh S et al. Protein prenyltransferases. 2003 Genome Biol. pmid:12702202
Zhang ZD et al. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. 2010 Genome Biol. pmid:20210993
Iwasaki S Photochemistry of imidazolides II. C2-C3 cleavage of carboxylic acid chains. A convenient new method for the side-chain degradation of bile acids and of lanosterol. 1976 Helv. Chim. Acta pmid:1017974
Lou HY et al. Hepatic failure related to itraconazole use successfully treated by corticosteroids. 2011 Hepat Mon pmid:22224084
Clark PJ et al. Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. 2012 Hepatology pmid:22318926
Stojakovic T et al. Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid. 2007 Hepatology pmid:17668874
Miettinen TE et al. The effects of ursodeoxycholic acid on serum and biliary noncholesterol sterols in patients with gallstones. 1997 Hepatology pmid:9049189
Vazquez JA Optimal management of oropharyngeal and esophageal candidiasis in patients living with HIV infection. 2010 HIV AIDS (Auckl) pmid:22096388
Omoigui S The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. 2007 Immun Ageing pmid:17374166
Das J et al. Oral itraconazole for the treatment of severe seborrhoeic dermatitis. 2011 Sep-Oct Indian J Dermatol pmid:22121267
Venkatesh R et al. Comment to: Effect of lanosterol on human nuclei. 2016 Indian J Ophthalmol pmid:27488164
Shanmugam PM et al. Effect of lanosterol on human cataract nucleus. 2015 Indian J Ophthalmol pmid:26862091
Sangamwar AT et al. Antifungals: need to search for a new molecular target. 2008 Jul-Aug Indian J Pharm Sci pmid:20046765
Ankam R et al. Simultaneous HPLC determination of butenafine hydrochloride and betamethasone in a cream formulation. 2009 Indian J Pharm Sci pmid:20502575
Lat A and Thompson GR Update on the optimal use of voriconazole for invasive fungal infections. 2011 Infect Drug Resist pmid:21694908
Ianas V et al. Role of posaconazole in the treatment of oropharyngeal candidiasis. 2010 Infect Drug Resist pmid:21694893
Askarova S et al. Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes. 2011 Int J Alzheimers Dis pmid:21547213
Ader F et al. Management of invasive aspergillosis in patients with COPD: rational use of voriconazole. 2009 Int J Chron Obstruct Pulmon Dis pmid:19684861
Lütjohann D et al. 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. 2009 Int J Clin Pharmacol Ther pmid:19954708
Pérez-Castrillón JL et al. Vitamin d levels and lipid response to atorvastatin. 2010 Int J Endocrinol pmid:20016682
Vidal-Limon AM et al. Molecular Dynamics and Virtual Screening Analysis of Lanosterol Derivatives from Ganoderma Medicinal Mushrooms (Agaricomycetes) as Selective Ligands of Human Androgen Receptor. 2017 Int J Med Mushrooms pmid:29199581
Suarez-Medellin J et al. In Silico Analysis of Lanostanoids Characterized in Ganoderma Mushrooms (Agaricomycetes) as Potential Ligands of the Vitamin D Receptor. 2016 Int J Med Mushrooms pmid:28008815
Yajima Y et al. Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A. 2013 Int J Med Mushrooms pmid:23557369
Wang J et al. Protective Effect of Eburicoic Acid of the Chicken of the Woods Mushroom, Laetiporus sulphureus (Higher Basidiomycetes), Against Gastric Ulcers in Mice. 2015 Int J Med Mushrooms pmid:26559696
Wang XL et al. Efficient Accumulation and In Vitro Antitumor Activities of Triterpene Acids from Submerged Batch--Cultured Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes). 2017 Int J Med Mushrooms pmid:28845771
Vandeputte P et al. Antifungal resistance and new strategies to control fungal infections. 2012 Int J Microbiol pmid:22187560
Acero FJ et al. Development of proteomics-based fungicides: new strategies for environmentally friendly control of fungal plant diseases. 2011 Int J Mol Sci pmid:21340014
Kim JW et al. Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. 2016 Int J Mol Sci pmid:27801787
Kuo YH et al. Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor α Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice. 2016 Int J Mol Sci pmid:27271603
Lin CH et al. Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice. 2017 Int J Mol Sci pmid:29099085
Wang G et al. Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. 2007 Int. Immunopharmacol. pmid:17466920