lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with lanosterol

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Authors Title Published Journal PubMed Link
Gachotte D et al. A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9326581
Yeagle PL et al. Differential effects of cholesterol and lanosterol on artificial membranes. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:270726
Kaneshiro ES et al. Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874778
Gachotte D et al. Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10535978
Shibata N et al. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11226224
Ohyama K et al. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19139393
Chang TY et al. Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:265577
Zheng YH et al. Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12824470
Lee SS et al. Application of modern NMR techniques in the structure determination of microbial transformation products from sterols. 1991 Proc. Natl. Sci. Counc. Repub. China B pmid:1946817
Cornforth J Symmetry of squalene epoxidation in vivo. 1977 Proc. R. Soc. Lond., B, Biol. Sci. pmid:22855