MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tint GS and Salen G | Biosynthesis of cholesterol, lanosterol, and delta 7-cholestenol, but not cholestanol, in cultured fibroblasts from normal individuals and patients with cerebrotendinous xanthomatosis. | 1982 | J. Lipid Res. | pmid:7097124 |
Ciavatti M et al. | Biosynthesis of platelet lipids in relation to aggregation in women using oral contraceptives. | 1982 | Contraception | pmid:7116849 |
Maugh TH | Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. | 1982 | Science | pmid:7146911 |
Ranganathan S et al. | Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. | 1982 | Atherosclerosis | pmid:7150392 |
Burns CP et al. | Mechanism of defective sterol synthesis in human leukocytes. | 1982 | Biochim. Biophys. Acta | pmid:7150625 |
Fukushima H et al. | Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase. | 1981 | J. Biol. Chem. | pmid:7228857 |
Hemmi H et al. | Selective inhibition of nucleoside transport into mouse lymphoma L-5178Y cells by cimicfugoside. | 1980 | J. Pharmacobio-dyn. | pmid:7277178 |
Hemmi H and Ishida N | The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. | 1980 | J. Pharmacobio-dyn. | pmid:7277179 |
Parish EJ and Schroepfer GJ | Sterol synthesis. A simplified method for the synthesis of 32-oxygenated derivatives of 24,25-dihydrolanosterol. | 1981 | J. Lipid Res. | pmid:7288292 |
Song MK and Dempsey ME | Requirement for a major soluble protein in the conversion of lanosterol to cholesterol by membrane-bound enzymes. | 1981 | Arch. Biochem. Biophys. | pmid:7305386 |