| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dantas-Leite L et al. | Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii. | 2005 | Int. J. Antimicrob. Agents | pmid:15664482 |
| Dantas-Leite L et al. | Selective anti-Toxoplasma gondii activities of azasterols. | 2004 | Int. J. Antimicrob. Agents | pmid:15194134 |
| Jiang J et al. | Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. | 2008 | Int. J. Mol. Med. | pmid:18425349 |
| Thyagarajan A et al. | Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. | 2006 | Int. J. Mol. Med. | pmid:16964420 |
| Cheng S et al. | Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7. | 2013 | Int. J. Oncol. | pmid:23588713 |
| Jedinak A et al. | Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling. | 2011 | Int. J. Oncol. | pmid:21225227 |
| Prasad R and Kapoor K | Multidrug resistance in yeast Candida. | 2005 | Int. Rev. Cytol. | pmid:15598470 |
| de Souza W and Rodrigues JC | Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 | Interdiscip Perspect Infect Dis | pmid:19680554 |
| Nicolaides N et al. | Meibomian gland dysfunction. III. Meibomian gland lipids. | 1989 | Invest. Ophthalmol. Vis. Sci. | pmid:2498228 |
| Pan RL et al. | Two new cyclolanostanol glycosides from the aerial parts of Cimicifuga foetida. | 2004 | J Asian Nat Prod Res | pmid:14989382 |
| Hu LL et al. | Three new lanostanoid triterpenes from the fruiting bodies of Ganoderma tropicum. | 2013 | J Asian Nat Prod Res | pmid:23421432 |
| Katja DG et al. | Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae). | 2017 | J Asian Nat Prod Res | pmid:27329305 |
| Feng W and Yang JS | A new drimane sesquiterpenoid and a new triterpene lactone from fungus of Fomes officinalis. | 2015 | J Asian Nat Prod Res | pmid:26123159 |
| Yin X et al. | Four lanostane-type triterpenes from the fruiting bodies of mushroom Laetiporus sulphureus var. miniatus. | 2015 | J Asian Nat Prod Res | pmid:25916960 |
| Wang JL et al. | A new ganoderic acid from Ganoderma lucidum mycelia. | 2010 | J Asian Nat Prod Res | pmid:20706913 |
| Kirchmair J et al. | Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms. | 2012 | J Chem Inf Model | pmid:22339582 |
| DOREE C et al. | Lanosterol; hydrocarbons formed by the action of dehydrating agents. | 1947 | J Chem Soc | pmid:18920806 |
| Riddle LA and Guiochon G | Separation of free sterols by high temperature liquid chromatography. | 2006 | J Chromatogr A | pmid:17055522 |
| He K et al. | Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products. | 2006 | J Chromatogr A | pmid:16515793 |
| Lv L et al. | Quantitation of lanosterol in the vitreous humor of rabbits after ocular administration of lanosterol/thermogel formulation by ultra high performance liquid chromatography-tandem mass spectrometry with the electrospray ionization mode. | 2017 | J Chromatogr A | pmid:28888677 |
| Schrack S et al. | Oxysterols in cosmetics-Determination by planar solid phase extraction and gas chromatography-mass spectrometry. | 2016 | J Chromatogr A | pmid:28314390 |
| Jover E et al. | Complete characterisation of lanolin steryl esters by sub-ambient pressure gas chromatography-mass spectrometry in the electron impact and chemical ionisation modes. | 2002 | J Chromatogr A | pmid:12350098 |
| Abid SL et al. | Elution behavior of unsaponifiable lipids with various capillary electrochromatographic stationary phases. | 2002 | J Chromatogr A | pmid:11999735 |
| Cournia Z et al. | A molecular mechanics force field for biologically important sterols. | 2005 | J Comput Chem | pmid:16028234 |
| Schulz-Gasch T and Stahl M | Mechanistic insights into oxidosqualene cyclizations through homology modeling. | 2003 | J Comput Chem | pmid:12666166 |
| Froufe HJ et al. | Virtual screening of low molecular weight mushrooms compounds as potential Mdm2 inhibitors. | 2013 | J Enzyme Inhib Med Chem | pmid:22380771 |
| Gai YY et al. | Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats. | 2012 | J Ethnopharmacol | pmid:22771280 |
| Singh R et al. | HILIC quantification of oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages. | 2012 | J Ethnopharmacol | pmid:22414479 |
| Ha do T et al. | In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress. | 2013 | J Ethnopharmacol | pmid:24140584 |
| Sundar S and Chakravarty J | Liposomal amphotericin B and leishmaniasis: dose and response. | 2010 | J Glob Infect Dis | pmid:20606972 |
| Boone LR et al. | Mechanism of resistance to dietary cholesterol. | 2011 | J Lipids | pmid:22007308 |
| Heimark L et al. | Mechanism of azole antifungal activity as determined by liquid chromatographic/mass spectrometric monitoring of ergosterol biosynthesis. | 2002 | J Mass Spectrom | pmid:11921367 |
| Tavallaee M and Rad MM | Fixed drug eruption resulting from fluconazole use: a case report. | 2009 | J Med Case Rep | pmid:19830193 |
| Nowosielski M and Hoffmann M | Do the substituent effects affect conformational freedom of squalene in hopene biosynthesis? | 2011 | J Mol Model | pmid:21562825 |
| Amen YM et al. | Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells. | 2016 | J Nat Med | pmid:26899240 |
| Zhang Q et al. | Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. | 2009 | J Nat Med | pmid:19407927 |
| Mueller AM et al. | Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. | 2008 | J Neuroinflammation | pmid:18501024 |
| Novack GD | Eyes on New Product Development. | 2016 | J Ocul Pharmacol Ther | pmid:27058691 |
| Sugai M et al. | Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside. | 2009 | J Oleo Sci | pmid:19145063 |
| Kawashima H et al. | Distribution of unusual cholesterol precursors, 4-methyl- and 4, 4-dimethylsterols with δ8 unsaturation, in gonads of marine archaeogastropods. | 2013 | J Oleo Sci | pmid:23823912 |
| Brannian J et al. | Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. | 2009 | J Ovarian Res | pmid:19650929 |
| Raudino A et al. | The thermodynamics of simple biomembrane mimetic systems. | 2011 | J Pharm Bioallied Sci | pmid:21430953 |
| Ding N et al. | Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis. | 2010 | J Pharm Biomed Anal | pmid:20719456 |
| Liu Y et al. | Sensitive and selective liquid chromatography-tandem mass spectrometry method for the determination of five ganoderic acids in Ganoderma lucidum and its related species. | 2011 | J Pharm Biomed Anal | pmid:21130592 |
| Wang Y et al. | Simultaneous determination of cimicifugoside H-2, cimicifugoside H-1, 23-epi-26-deoxyactein, cimigenol xyloside and 25-O-acetylcimigenoside in beagle dog plasma by LC-MS/MS. | 2012 | J Pharm Biomed Anal | pmid:22285707 |
| Harris PA and Harris KL | Quantitative GLC analysis of plasma cholesterol. | 1974 | J Pharm Sci | pmid:4830004 |
| Takei M et al. | Mechanism of inhibition of IgE-dependent histamine release from rat mast cells by penasterol and penasterone. | 1995 | J Pharm Sci | pmid:7537812 |
| Livanec PW et al. | Exploring the effects of sterols in model lipid membranes using single-molecule orientations. | 2009 | J Phys Chem B | pmid:19572622 |
| Sen K and Hackett JC | Molecular oxygen activation and proton transfer mechanisms in lanosterol 14alpha-demethylase catalysis. | 2009 | J Phys Chem B | pmid:19438188 |
| Cournia Z et al. | Differential effects of cholesterol, ergosterol and lanosterol on a dipalmitoyl phosphatidylcholine membrane: a molecular dynamics simulation study. | 2007 | J Phys Chem B | pmid:17261058 |