| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Horvath SE et al. | Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae. | 2011 | Biochim. Biophys. Acta | pmid:21875690 |
| Acero FJ et al. | Development of proteomics-based fungicides: new strategies for environmentally friendly control of fungal plant diseases. | 2011 | Int J Mol Sci | pmid:21340014 |
| Nowosielski M and Hoffmann M | Do the substituent effects affect conformational freedom of squalene in hopene biosynthesis? | 2011 | J Mol Model | pmid:21562825 |
| Krasowski MD et al. | The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. | 2011 | BMC Biochem. | pmid:21291553 |
| Nes WD | Biosynthesis of cholesterol and other sterols. | 2011 | Chem. Rev. | pmid:21902244 |
| Sangshetti JN et al. | Synthesis, antifungal activity, and docking study of some new 1,2,4-triazole analogs. | 2011 | Chem Biol Drug Des | pmid:21752200 |
| Jiang Y et al. | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21737273 |
| Xu J et al. | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. | 2011 | Eur J Med Chem | pmid:21420761 |
| Sheng C et al. | Structure-based design, synthesis, and antifungal activity of new triazole derivatives. | 2011 | Chem Biol Drug Des | pmid:21585708 |
| Gleason JE et al. | Analysis of hypoxia and hypoxia-like states through metabolite profiling. | 2011 | PLoS ONE | pmid:21931840 |
| Baumann K et al. | Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris. | 2011 | Microb. Cell Fact. | pmid:22050768 |
| Sawai S and Saito K | Triterpenoid biosynthesis and engineering in plants. | 2011 | Front Plant Sci | pmid:22639586 |
| Borecká S et al. | Cdr2p contributes to fluconazole resistance in Candida dubliniensis clinical isolates. | 2011 | Can. J. Microbiol. | pmid:21542785 |
| Askarova S et al. | Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes. | 2011 | Int J Alzheimers Dis | pmid:21547213 |
| Cantu D et al. | Next generation sequencing provides rapid access to the genome of Puccinia striiformis f. sp. tritici, the causal agent of wheat stripe rust. | 2011 | PLoS ONE | pmid:21909385 |
| Jiang J et al. | Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22033405 |
| Stottmann RW et al. | Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. | 2011 | PLoS Genet. | pmid:21912524 |
| Wang N et al. | N-Cyclo-propyl-N-[2-(2,4-difluoro-phen-yl)-2-hy-droxy-1-(1H-1,2,4-triazol-1-yl)prop-yl]-2-(5-methyl-2,4-dioxo-1,2,3,4-tetra-hydro-pyrimidin-1-yl)acetamide dichloro-methane 0.62-solvate. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22059025 |
| Vanmierlo T et al. | Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. | 2011 | Plant Foods Hum Nutr | pmid:21431910 |
| Wang Z et al. | Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids. | 2011 | Plant Physiol. | pmid:21059824 |
| Idkowiak J et al. | Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21190981 |
| Chauvigné F et al. | Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. | 2011 | PLoS ONE | pmid:22087261 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Nacev BA and Liu JO | Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole. | 2011 | PLoS ONE | pmid:21969860 |
| Raudino A et al. | The thermodynamics of simple biomembrane mimetic systems. | 2011 | J Pharm Bioallied Sci | pmid:21430953 |
| Park HG et al. | Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans. | 2011 | Arch. Biochem. Biophys. | pmid:21315684 |
| Ito R et al. | Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases. | 2011 | Org. Lett. | pmid:21526825 |
| Ogbuewu IP et al. | The potentiality of medicinal plants as the source of new contraceptive principles in males. | 2011 | N Am J Med Sci | pmid:22540095 |
| Oliaro-Bosso S et al. | Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase. | 2011 | PLoS ONE | pmid:21811565 |
| Burkhardt R et al. | Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21252064 |
| Jedinak A et al. | Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling. | 2011 | Int. J. Oncol. | pmid:21225227 |
| Rosa Ide A et al. | Ultrastructural alterations induced by Δ(24(25))-sterol methyltransferase inhibitors on Trichomonas vaginalis. | 2011 | FEMS Microbiol. Lett. | pmid:21175744 |
| Wu TK et al. | Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17α/β-exocyclic side chain stereochemistry. | 2011 | Org. Biomol. Chem. | pmid:21157613 |
| Nguyen HD et al. | Friedolanostane, friedocycloartane and benzophenone constituents of the bark and leaves of Garcinia benthami. | 2011 | Phytochemistry | pmid:21168174 |
| Parker JE et al. | Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals. | 2011 | Appl. Environ. Microbiol. | pmid:21169436 |
| Tripodi KE et al. | Role of heme and heme-proteins in trypanosomatid essential metabolic pathways. | 2011 | Enzyme Res | pmid:21603276 |
| Oh HG et al. | Effects of Ficus carica paste on constipation induced by a high-protein feed and movement restriction in beagles. | 2011 | Lab Anim Res | pmid:22232635 |
| Lou HY et al. | Hepatic failure related to itraconazole use successfully treated by corticosteroids. | 2011 | Hepat Mon | pmid:22224084 |
| Semighini CP et al. | Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. | 2011 | PLoS Pathog. | pmid:22114551 |
| Wang X et al. | Genome-wide linkage scan of a pedigree with familial hypercholesterolemia suggests susceptibility loci on chromosomes 3q25-26 and 21q22. | 2011 | PLoS ONE | pmid:22022364 |
| Boone LR et al. | Mechanism of resistance to dietary cholesterol. | 2011 | J Lipids | pmid:22007308 |
| Hoot SJ et al. | The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity. | 2011 | BMC Microbiol. | pmid:21951709 |
| Jensen PA et al. | TIGER: Toolbox for integrating genome-scale metabolic models, expression data, and transcriptional regulatory networks. | 2011 | BMC Syst Biol | pmid:21943338 |
| Acimovic J et al. | Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis. | 2011 | Drug Metab. Dispos. | pmid:20952551 |
| Reynaud EG and Devos DP | Transitional forms between the three domains of life and evolutionary implications. | 2011 | Proc. Biol. Sci. | pmid:21920985 |
| Cabrito TR et al. | The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. | 2011 | Biochem. J. | pmid:21831043 |
| Chadwick W et al. | Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. | 2011 | PLoS ONE | pmid:21738745 |
| Mullins JG et al. | Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola. | 2011 | PLoS ONE | pmid:21738598 |
| Singh A and Prasad R | Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints. | 2011 | PLoS ONE | pmid:21559392 |
| Mayr A and Lass-Flörl C | Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. | 2011 | Eur. J. Med. Res. | pmid:21486729 |
| Sandherr M and Maschmeyer G | Pharmacology and metabolism of voriconazole and Posaconazole in the treatment of invasive aspergillosis: review of the literature. | 2011 | Eur. J. Med. Res. | pmid:21486727 |
| Bisi-Johnson MA et al. | Evaluation of the antibacterial and anticancer activities of some South African medicinal plants. | 2011 | BMC Complement Altern Med | pmid:21329526 |
| D'Souza CA et al. | Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. | 2011 | MBio | pmid:21304167 |
| Vargas FA et al. | Expanding a dynamic flux balance model of yeast fermentation to genome-scale. | 2011 | BMC Syst Biol | pmid:21595919 |
| Choi MH et al. | Metabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma. | 2011 | BMC Cancer | pmid:21824401 |
| Kim D et al. | Functional expression and characterization of CYP51 from dandruff-causing Malassezia globosa. | 2011 | FEMS Yeast Res. | pmid:21114623 |
| Leichner GS et al. | Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. | 2011 | J. Biol. Chem. | pmid:21778231 |
| Dutra RC et al. | Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. | 2011 | PLoS ONE | pmid:22073270 |
| Fakheri RJ and Javitt NB | Autoregulation of cholesterol synthesis: physiologic and pathophysiologic consequences. | 2011 | Steroids | pmid:20951718 |
| Koturbash I et al. | Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. | 2011 | Environ. Health Perspect. | pmid:21147608 |
| Leoni V et al. | Whole body cholesterol metabolism is impaired in Huntington's disease. | 2011 | Neurosci. Lett. | pmid:21406216 |
| Kaddurah-Daouk R et al. | Enteric microbiome metabolites correlate with response to simvastatin treatment. | 2011 | PLoS ONE | pmid:22022402 |
| Chen NH and Zhong JJ | p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. | 2011 | Phytomedicine | pmid:21353507 |
| Zhong XH et al. | Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549. | 2011 | Chin J Integr Med | pmid:21359924 |
| Leichtle AB et al. | Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men. | 2011 | Am. J. Clin. Nutr. | pmid:21940598 |
| Paller AS et al. | Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolism. | 2011 | J. Invest. Dermatol. | pmid:21753784 |
| Kennedy EM et al. | Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols. | 2011 | J. Nat. Prod. | pmid:22044278 |
| Sang ZG et al. | [Studies on the secondary metabolites of Coriolopsis sp. G066]. | 2011 | Zhong Yao Cai | pmid:21809540 |
| Zhao Z et al. | Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol. | 2011 | Appl. Microbiol. Biotechnol. | pmid:20809073 |
| Chen NH et al. | Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. | 2010 Jan-Feb | Pharmacol Rep | pmid:20360625 |
| Cavalier-Smith T | Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. | 2010 | Biol. Direct | pmid:20132544 |
| Brumfield KM et al. | Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. | 2010 | PLoS ONE | pmid:20084111 |
| Koivusalo AI et al. | Cholesterol, non-cholesterol sterols and bile acids in paediatric gallstones. | 2010 | Dig Liver Dis | pmid:19632165 |
| Yadav VR et al. | Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. | 2010 | Toxins (Basel) | pmid:22069560 |
| Serra M et al. | Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20804844 |
| Wang JL et al. | A new ganoderic acid from Ganoderma lucidum mycelia. | 2010 | J Asian Nat Prod Res | pmid:20706913 |
| Ding N et al. | Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis. | 2010 | J Pharm Biomed Anal | pmid:20719456 |
| Shi L et al. | Current progress in the study on biosynthesis and regulation of ganoderic acids. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20859739 |
| Noel JP et al. | Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. | 2010 | ACS Chem. Biol. | pmid:20175559 |
| Taramino S et al. | Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. | 2010 | Biochim. Biophys. Acta | pmid:20659585 |
| Straud S et al. | Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. | 2010 | PLoS ONE | pmid:20661293 |
| Marco-Jiménez F et al. | Effects of lanosterol on in vitro maturation of porcine oocytes. | 2010 | Anim. Reprod. Sci. | pmid:19473792 |
| Xu JW et al. | Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19578843 |
| Mansfield BE et al. | Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. | 2010 | PLoS Pathog. | pmid:20941354 |
| Liu XT et al. | Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis. | 2010 | Planta Med. | pmid:19644795 |
| Ottaviani M et al. | Lipid mediators in acne. | 2010 | Mediators Inflamm. | pmid:20871834 |
| Liu J et al. | Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria. | 2010 | Planta Med. | pmid:19670160 |
| LaFayette SL et al. | PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. | 2010 | PLoS Pathog. | pmid:20865172 |
| Ferreira C et al. | Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p. | 2010 | BMC Microbiol. | pmid:20843317 |
| Fernandez-Arche A et al. | Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. | 2010 | Phytomedicine | pmid:19577446 |
| Iskar M et al. | Drug-induced regulation of target expression. | 2010 | PLoS Comput. Biol. | pmid:20838579 |
| Chung MJ et al. | Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells. | 2010 | Nutr Res Pract | pmid:20607061 |
| Zhu LW and Tang YJ | Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides during the fermentation of Ganoderma lucidum. | 2010 | Bioprocess Biosyst Eng | pmid:20369259 |
| Solberg R et al. | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. | 2010 | PLoS ONE | pmid:20231903 |
| Zhang ZD et al. | Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. | 2010 | Genome Biol. | pmid:20210993 |
| Batova M et al. | Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine). | 2010 | BMC Genomics | pmid:20202201 |
| Epp E et al. | Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. | 2010 | PLoS Pathog. | pmid:20140196 |
| Vazquez JA | Optimal management of oropharyngeal and esophageal candidiasis in patients living with HIV infection. | 2010 | HIV AIDS (Auckl) | pmid:22096388 |
| Ianas V et al. | Role of posaconazole in the treatment of oropharyngeal candidiasis. | 2010 | Infect Drug Resist | pmid:21694893 |
| Ahmad A et al. | Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. | 2010 | Microb. Pathog. | pmid:19835945 |