| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kölsch H et al. | Alterations of cholesterol precursor levels in Alzheimer's disease. | 2010 | Biochim. Biophys. Acta | pmid:20226877 |
| Urzúa U et al. | Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis. | 2010 | BMC Genomics | pmid:21210965 |
| Feng LJ et al. | Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene. | 2010 | Chin. Med. J. | pmid:20367978 |
| Xu Y et al. | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20362444 |
| Lu X et al. | Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus. | 2010 | J. Sci. Food Agric. | pmid:20355042 |
| Lee CH et al. | Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea. | 2010 | J. Agric. Food Chem. | pmid:20334412 |
| Morio F et al. | Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. | 2010 | Diagn. Microbiol. Infect. Dis. | pmid:20226328 |
| Targett-Adams P et al. | Lipid metabolism and HCV infection. | 2010 | Viruses | pmid:21994676 |
| Kim JH et al. | Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. | 2010 | J. Neurochem. | pmid:19860851 |
| Aono T et al. | Direct electrochemical analyses of human cytochromes b5 with a mutated heme pocket showed a good correlation between their midpoint and half wave potentials. | 2010 | J. Biomed. Sci. | pmid:21129218 |
| Hu J et al. | Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. | 2010 | Nutr Metab (Lond) | pmid:20515451 |
| Al-Badriyeh D et al. | Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis. | 2010 | Clin Ophthalmol | pmid:20463910 |
| Jarvie E et al. | Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. | 2010 | Clin. Sci. | pmid:20443782 |
| Kraus JM et al. | Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. | 2010 | J. Med. Chem. | pmid:20429511 |
| Pereira M et al. | Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis. | 2010 | Biochim. Biophys. Acta | pmid:20624480 |
| Warrilow AG et al. | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. | 2010 | Antimicrob. Agents Chemother. | pmid:20660663 |
| Liang CX et al. | Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20077112 |
| Lee I et al. | Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells. | 2010 | J. Nat. Prod. | pmid:20039640 |
| Che S et al. | [RP-HPLC simultaneous determination of five triterpenoid acids in different parts of Poria cocos by UV wavelengths switch]. | 2010 | Yao Xue Xue Bao | pmid:21355217 |
| Wyder MA et al. | Clearance in vivo of instilled [h]cholesterol from the rat lung. | 2010 | Biochem Res Int | pmid:21188079 |