| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Beattie ME et al. | Sterol structure determines miscibility versus melting transitions in lipid vesicles. | 2005 | Biophys. J. | pmid:15951379 |
| Huang TH et al. | Effect of cholesterol and lanosterol on the structure and dynamics of the cell membrane of Mycoplasma capricolum. Deuterium nuclear magnetic resonance study. | 1991 | Biophys. J. | pmid:2049526 |
| Scheidt HA et al. | Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR. | 2005 | Biophys. J. | pmid:16085761 |
| Shahedi V et al. | Domain-formation in DOPC/SM bilayers studied by pfg-NMR: effect of sterol structure. | 2006 | Biophys. J. | pmid:16829566 |
| Mannock DA et al. | Comparative calorimetric and spectroscopic studies of the effects of lanosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. | 2006 | Biophys. J. | pmid:16905603 |
| Sabatini K et al. | Interfacial behavior of cholesterol, ergosterol, and lanosterol in mixtures with DPPC and DMPC. | 2008 | Biophys. J. | pmid:18515391 |
| Smondyrev AM and Berkowitz ML | Molecular dynamics simulation of the structure of dimyristoylphosphatidylcholine bilayers with cholesterol, ergosterol, and lanosterol. | 2001 | Biophys. J. | pmid:11259280 |
| Henriksen J et al. | Universal behavior of membranes with sterols. | 2006 | Biophys. J. | pmid:16326903 |
| Urbina JA et al. | A carbon-13 nuclear magnetic resonance spectroscopic study of inter-proton pair order parameters: a new approach to study order and dynamics in phospholipid membrane systems. | 1998 | Biophys. J. | pmid:9726938 |
| Miao L et al. | From lanosterol to cholesterol: structural evolution and differential effects on lipid bilayers. | 2002 | Biophys. J. | pmid:11867458 |
| Huster D et al. | Desmosterol may replace cholesterol in lipid membranes. | 2005 | Biophys. J. | pmid:15596512 |
| Stottrup BL and Keller SL | Phase behavior of lipid monolayers containing DPPC and cholesterol analogs. | 2006 | Biophys. J. | pmid:16461392 |
| Hildenbrand MF and Bayerl TM | Differences in the modulation of collective membrane motions by ergosterol, lanosterol, and cholesterol: a dynamic light scattering study. | 2005 | Biophys. J. | pmid:15764657 |
| Nöllmann M et al. | The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin. | 2004 | Biophys. J. | pmid:15111427 |
| Charbonneau C et al. | The interactions of amphotericin B with various sterols in relation to its possible use in anticancer therapy. | 2001 | Biophys. Chem. | pmid:11429202 |
| Wada S and Tanaka R | Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15914002 |
| Jiang Y et al. | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21737273 |
| Wang W et al. | Discovery of highly potent novel antifungal azoles by structure-based rational design. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19748782 |
| Zhu J et al. | Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16905318 |
| Stead P et al. | Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10762048 |