lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with lanosterol

Download all related citations
Per page 10 20 50 100 | Total 1125
Authors Title Published Journal PubMed Link
Sangshetti JN et al. Synthesis, antifungal activity, and docking study of some new 1,2,4-triazole analogs. 2011 Chem Biol Drug Des pmid:21752200
Jiang Y et al. Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. 2011 Bioorg. Med. Chem. Lett. pmid:21737273
Sheng C et al. Structure-based design, synthesis, and antifungal activity of new triazole derivatives. 2011 Chem Biol Drug Des pmid:21585708
Spitzer M et al. Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. 2011 Mol. Syst. Biol. pmid:21694716
Askarova S et al. Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes. 2011 Int J Alzheimers Dis pmid:21547213
Chauvigné F et al. Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. 2011 PLoS ONE pmid:22087261
Zhang XQ et al. Triterpenoids with neurotrophic activity from Ganoderma lucidum. 2011 Nat. Prod. Res. pmid:21671206
Park HG et al. Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans. 2011 Arch. Biochem. Biophys. pmid:21315684
Ito R et al. Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases. 2011 Org. Lett. pmid:21526825
Burkhardt R et al. Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice. 2011 Arterioscler. Thromb. Vasc. Biol. pmid:21252064
Jedinak A et al. Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling. 2011 Int. J. Oncol. pmid:21225227
Tripodi KE et al. Role of heme and heme-proteins in trypanosomatid essential metabolic pathways. 2011 Enzyme Res pmid:21603276
Semighini CP et al. Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. 2011 PLoS Pathog. pmid:22114551
Lat A and Thompson GR Update on the optimal use of voriconazole for invasive fungal infections. 2011 Infect Drug Resist pmid:21694908
Singh A and Prasad R Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints. 2011 PLoS ONE pmid:21559392
Mayr A and Lass-Flörl C Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. 2011 Eur. J. Med. Res. pmid:21486729
Sandherr M and Maschmeyer G Pharmacology and metabolism of voriconazole and Posaconazole in the treatment of invasive aspergillosis: review of the literature. 2011 Eur. J. Med. Res. pmid:21486727
Vargas FA et al. Expanding a dynamic flux balance model of yeast fermentation to genome-scale. 2011 BMC Syst Biol pmid:21595919
Dutra RC et al. Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. 2011 PLoS ONE pmid:22073270
Zhao Z et al. Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol. 2011 Appl. Microbiol. Biotechnol. pmid:20809073