| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ori K et al. | Lanosterol and tetranorlanosterol glycosides from the bulbs of Muscari paradoxum. | 2003 | Phytochemistry | pmid:14629999 |
| Huang SZ et al. | Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum. | 2017 | Phytochemistry | pmid:28800421 |
| Wang GW et al. | Lanostane-type triterpenoids from Abies faxoniana and their DNA topoisomerase inhibitory activities. | 2015 | Phytochemistry | pmid:25986863 |
| Du YC et al. | Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. | 2012 | Phytomedicine | pmid:22516893 |
| Fernandez-Arche A et al. | Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. | 2010 | Phytomedicine | pmid:19577446 |
| Chen NH and Zhong JJ | p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. | 2011 | Phytomedicine | pmid:21353507 |
| Ruan W et al. | Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells. | 2015 | Phytother Res | pmid:26292672 |
| Suzuki M et al. | Lanosterol synthase in dicotyledonous plants. | 2006 | Plant Cell Physiol. | pmid:16531458 |
| Sawai S et al. | Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes. | 2006 | Plant Cell Physiol. | pmid:16531457 |
| Vanmierlo T et al. | Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. | 2011 | Plant Foods Hum Nutr | pmid:21431910 |
| Husselstein-Muller T et al. | Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana. | 2001 | Plant Mol. Biol. | pmid:11247608 |
| Chen Q et al. | Biosynthesis of phytosterol esters: identification of a sterol o-acyltransferase in Arabidopsis. | 2007 | Plant Physiol. | pmid:17885082 |
| O'Brien M et al. | Lipid signaling in plants. Cloning and expression analysis of the obtusifoliol 14alpha-demethylase from Solanum chacoense Bitt., a pollination- and fertilization-induced gene with both obtusifoliol and lanosterol demethylase activity. | 2005 | Plant Physiol. | pmid:16169959 |
| Wang Z et al. | Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids. | 2011 | Plant Physiol. | pmid:21059824 |
| Carland F et al. | The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products. | 2010 | Plant Physiol. | pmid:20421456 |
| Koyama K et al. | Antinociceptive components of Ganoderma lucidum. | 1997 | Planta Med. | pmid:9225603 |
| Min BS et al. | Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. | 2001 | Planta Med. | pmid:11745016 |
| Yao X et al. | Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. | 2012 | Planta Med. | pmid:22961117 |
| Wang N et al. | Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea. | 2012 | Planta Med. | pmid:22948612 |
| Mosa RA et al. | In vitro antihyperlipidemic potential of triterpenes from stem bark of Protorhus longifolia. | 2014 | Planta Med. | pmid:25389058 |