| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rodriguez RJ et al. | Multiple functions for sterols in Saccharomyces cerevisiae. | 1985 | Biochim. Biophys. Acta | pmid:3904834 |
| Bennati AM et al. | Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis. | 2006 | Biochim. Biophys. Acta | pmid:16784888 |
| Su CY et al. | Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen. | 1999 | Biochim. Biophys. Acta | pmid:10064905 |
| Rebolj K et al. | Steroid structural requirements for interaction of ostreolysin, a lipid-raft binding cytolysin, with lipid monolayers and bilayers. | 2006 | Biochim. Biophys. Acta | pmid:16857161 |
| Hashimoto F and Hayashi H | Identification of intermediates after inhibition of cholesterol synthesis by aminotriazole treatment in vivo. | 1991 | Biochim. Biophys. Acta | pmid:1954238 |
| Aoyama Y et al. | Evidence for the presence of cytochrome P-450 functional in lanosterol 14 alpha-demethylation in microsomes of aerobically grown respiring yeast. | 1981 | Biochim. Biophys. Acta | pmid:6170339 |
| Schick BP and Schick PK | Cholesterol and phospholipid biosynthesis in guinea pig megakaryocytes. | 1981 | Biochim. Biophys. Acta | pmid:7011413 |
| Sánchez-Wandelmer J et al. | Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes. | 2009 | Biochim. Biophys. Acta | pmid:19433058 |
| Sonoda Y et al. | Purification of a human cytochrome P-450 isozyme catalyzing lanosterol 14 alpha-demethylation. | 1993 | Biochim. Biophys. Acta | pmid:8399332 |
| Taramino S et al. | Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. | 2010 | Biochim. Biophys. Acta | pmid:20659585 |
| Gibbons GF et al. | Metabolism of hydroxy sterols by rat liver. | 1980 | Biochim. Biophys. Acta | pmid:7417472 |
| Rahier A and Taton M | Plant sterol biosynthesis: 7-oxo-obtusifoliol analogues as potential selective inhibitors of cytochrome P-450 dependent obtusifoliol 14 alpha-demethylase. | 1992 | Biochim. Biophys. Acta | pmid:1571366 |
| Shumyantseva VV et al. | Electrochemical reduction of sterol-14alpha-demethylase from Mycobacterium tuberculosis (CYP51b1). | 2007 | Biochemistry Mosc. | pmid:17630911 |
| Lepesheva GI et al. | CYP51 from Trypanosoma brucei is obtusifoliol-specific. | 2004 | Biochemistry | pmid:15311940 |
| Lepesheva GI et al. | Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function. | 2003 | Biochemistry | pmid:12885242 |
| Wu TK and Griffin JH | Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis. | 2002 | Biochemistry | pmid:12081472 |
| Xu X and London E | The effect of sterol structure on membrane lipid domains reveals how cholesterol can induce lipid domain formation. | 2000 | Biochemistry | pmid:10653627 |
| Berry DJ and Chang TY | Further characterization of a Chinese hamster ovary cell mutant defective in lanosterol demethylation. | 1982 | Biochemistry | pmid:7066308 |
| Endress E et al. | Anisotropic motion and molecular dynamics of cholesterol, lanosterol, and ergosterol in lecithin bilayers studied by quasi-elastic neutron scattering. | 2002 | Biochemistry | pmid:12390036 |
| Trzaskos JM et al. | Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: II. Time-dependent enzyme inactivation by selected oxylanosterol analogs. | 1995 | Biochemistry | pmid:7626637 |