| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang N et al. | Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea. | 2012 | Planta Med. | pmid:22948612 |
| Sakamoto S et al. | Detection of Ganoderic Acid A in Ganoderma lingzhi by an Indirect Competitive Enzyme-Linked Immunosorbent Assay. | 2016 | Planta Med. | pmid:27093250 |
| Munhoz AC et al. | Chemical and pharmacological investigation of the stem bark of Synadenium grantii. | 2014 | Planta Med. | pmid:24687740 |
| Mosa RA et al. | In vitro antihyperlipidemic potential of triterpenes from stem bark of Protorhus longifolia. | 2014 | Planta Med. | pmid:25389058 |
| Wang GJ et al. | Lanostanes from Phellinus igniarius and their iNOS inhibitory activities. | 2009 | Planta Med. | pmid:19557671 |
| Liu XT et al. | Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis. | 2010 | Planta Med. | pmid:19644795 |
| Liu J et al. | Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria. | 2010 | Planta Med. | pmid:19670160 |
| Fatmawati S et al. | Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum. | 2010 | Planta Med. | pmid:20379959 |
| Iskar M et al. | Drug-induced regulation of target expression. | 2010 | PLoS Comput. Biol. | pmid:20838579 |
| Thomas JH | Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates. | 2007 | PLoS Genet. | pmid:17500592 |
| Stottmann RW et al. | Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. | 2011 | PLoS Genet. | pmid:21912524 |
| Selmecki AM et al. | Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. | 2009 | PLoS Genet. | pmid:19876375 |
| Ma LJ et al. | Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. | 2009 | PLoS Genet. | pmid:19578406 |
| Chen CK et al. | Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. | 2009 | PLoS Negl Trop Dis | pmid:19190730 |
| Chen CK et al. | Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. | 2010 | PLoS Negl Trop Dis | pmid:20386598 |
| Martinez-Seara H et al. | Cholesterol induces specific spatial and orientational order in cholesterol/phospholipid membranes. | 2010 | PLoS ONE | pmid:20567600 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Nacev BA and Liu JO | Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole. | 2011 | PLoS ONE | pmid:21969860 |
| Riccombeni A et al. | Sequence and analysis of the genome of the pathogenic yeast Candida orthopsilosis. | 2012 | PLoS ONE | pmid:22563396 |
| Domitrovic T et al. | Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance. | 2010 | PLoS ONE | pmid:20567505 |