MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bojesen E et al. | Sterol biosynthesis in vitro of rat renal inner medulla. | 1973 | Biochim. Biophys. Acta | pmid:4713153 |
Gibbons GF and Mitropoulos KA | The effect of carbon monoxide on the nature of the accumulated 4,4-dimethyl sterol precursors of cholesterol during its biosynthesis from (2-14C)mevalonic acid in vitro. | 1973 | Biochem. J. | pmid:4724584 |
Gibbons GF et al. | A method for the rapid qualitative and quantitative analysis of 4,4-dimethyl sterols. | 1973 | J. Lipid Res. | pmid:4729975 |
Johnson RC and Shah SN | Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. | 1973 | Biochem. Biophys. Res. Commun. | pmid:4741538 |
Willett JD and Downey WL | Isolation and identification of lanosterol as a normal constituent of the lipids of the free living nematode Panagrellus redivivus. | 1973 | Comp. Biochem. Physiol., B | pmid:4747095 |
Tabacik C et al. | The squalene epoxidase-cyclase activity of human term placenta. | 1973 | FEBS Lett. | pmid:4747843 |
Wojciechowski ZA et al. | S-adenosyl-L-methionine-cycloartenol methyltransferase activity in cell-free systems from Trebouxia sp. and Scenedesmus obliquus. | 1973 | Biochem. J. | pmid:4774402 |
Entwistle N and Pratt AD | Studies of artefacts of the acid treatment of (23S)-lanosta-8,24-diene-3 ,23-diol. | 1973 | J. Chem. Soc. Perkin Trans. I | pmid:4795248 |
Raskin P and Siperstein MD | Mevalonate metabolism by renal tissue in vitro. | 1974 | J. Lipid Res. | pmid:4811213 |
Ganem B and Kellogg MS | Improved methods for the side-chain degradation of lanosterol. The synthesis of 4,4,14alpha-trimethyl-5alpha-pregn-8-en-20-one derivatives. | 1974 | J. Org. Chem. | pmid:4814784 |
Willett JD and Downey WL | Sterol biosynthesis in the free-living nematode Panagrellus redivivus. | 1974 | Biochem. J. | pmid:4822732 |
Harris PA and Harris KL | Quantitative GLC analysis of plasma cholesterol. | 1974 | J Pharm Sci | pmid:4830004 |
Gonzalez R et al. | Studies of sterol synthesis, synthesis regulation and transport in cultured human kidney. | 1974 | Exp. Cell Res. | pmid:4841900 |
Fetizon M et al. | New routes for the degradation of the lanosterol side chain. | 1974 | J. Org. Chem. | pmid:4853345 |
Bloch KE | Speculations on the evolution of sterol structure and function. | 1979 | CRC Crit. Rev. Biochem. | pmid:498798 |
Chang TY et al. | Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor. | 1979 | J. Biol. Chem. | pmid:500643 |
Nitchuk WM and Ainsworth L | The de novo synthesis of sterols and cholesterol from acetate-1- 14 C by sheep and pig placental and fetal liver slices in vitro. | 1972 | Steroids | pmid:5028884 |
Ramsey RB et al. | Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. | 1972 | J. Biol. Chem. | pmid:5030627 |
Bhattacharyya AK et al. | Excretion of sterols from the skin of normal and hypercholesterolemic humans. Implications for sterol balance studies. | 1972 | J. Clin. Invest. | pmid:5054464 |
Fox JE et al. | Photo-oxygenation of lanosteryl acetate. | 1972 | J. Chem. Soc. Perkin Trans. I | pmid:5064150 |