lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with lanosterol

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Authors Title Published Journal PubMed Link
Barton DH et al. Equilibration of 24,25-dibromides of lanosterol and derivatives. 1972 J. Chem. Soc. Perkin Trans. I pmid:5065342
Gibbons GF and Mitropoulos KA Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. 1972 Biochem. J. pmid:5073750
van Tamelen EE and Anderson RJ Biogenetic-type total synthesis. 24,25-Dihydrolanosterol, 24,25-dihydro- 13(17) -protosterol, isoeuphenol, (-)-isotirucallol, and parkeol. 1972 J. Am. Chem. Soc. pmid:5079966
Ortiz de Montellano PR et al. Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. 1979 Biochem. Biophys. Res. Commun. pmid:508352
Beastall GH et al. Studies on phytosterol biosynthesis: metabolism of 24,25-dihydrolanosterol and cholesterol in Ochromonas malhamensis. 1972 Biochem. J. pmid:5085559
Gibbons FG et al. Studies on the mechanism of lanosterol 14 alpha-demethylation. A requirement for two distinct types of mixed-function-oxidase systems. 1979 Biochem. J. pmid:534498
Burstein S et al. Specificity of the cholesterol side-chain cleavage enzyme system of adrenal cortex. 1977 Steroids pmid:605455
Aoyama Y et al. Involvement of cytochrome b5 and a cyanide-sensitive monooxygenase in the 4-demethylation of 4,4-dimethylzymosterol by yeast microsomes. 1981 Biochim. Biophys. Acta pmid:6163470
Aoyama Y et al. Evidence for the presence of cytochrome P-450 functional in lanosterol 14 alpha-demethylation in microsomes of aerobically grown respiring yeast. 1981 Biochim. Biophys. Acta pmid:6170339
Sarkar CP and Cenedella RJ Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. 1982 Lipids pmid:6177997
Trzaskos JM et al. Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation. 1984 J. Biol. Chem. pmid:6208195
Van den Bossche H et al. In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. 1980 Antimicrob. Agents Chemother. pmid:6250469
Sud IJ and Feingold DS Heterogeneity of action of mechanisms among antimycotic imidazoles. 1981 Antimicrob. Agents Chemother. pmid:6269485
Yoshida Y and Aoyama Y Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties. 1984 J. Biol. Chem. pmid:6363414
Nakanishi S et al. Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. 1984 J. Biochem. pmid:6397465
Aoyama Y et al. Altered cytochrome P-450 in a yeast mutant blocked in demethylating C-32 of lanosterol. 1983 J. Biol. Chem. pmid:6409899
Aoyama Y et al. Buthiobate: a potent inhibitor for yeast cytochrome P-450 catalyzing 14 alpha-demethylation of lanosterol. 1983 Biochem. Biophys. Res. Commun. pmid:6414474
Aoyama Y et al. Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes. 1984 J. Biol. Chem. pmid:6420412
Leonard DA and Chen HW Aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits conversion of lanosterol to C-27 sterols in mouse L cells. 1984 J. Biol. Chem. pmid:6425279
Chen HW and Leonard DA Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells. 1984 J. Biol. Chem. pmid:6429139