MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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AVIGAN J et al. | Studies of cholesterol biosynthesis. IV. Reduction of lanosterol to 24,25-dihydrolanosterol by rat liver homogenates. | 1963 | J. Biol. Chem. | pmid:13965665 |
LINDBERG M et al. | Ketonic intermediates in the demethylation of lanosterol. | 1963 | J. Biol. Chem. | pmid:13930748 |
KANDUTSCH AA and RUSSELL AE | Preputial gland tumor sterols. I. The occurrence of 24,25-dihydrolanosterol and a comparison with liver and the normal gland. | 1959 | J. Biol. Chem. | pmid:13673010 |
GAUTSCHI F and BLOCH K | Synthesis of isomeric 4,4-dimethylcholestenols and identification of a lanosterol metabolite. | 1958 | J. Biol. Chem. | pmid:13610839 |
OLSON JA et al. | On the demethylation of lanosterol to cholesterol. | 1957 | J. Biol. Chem. | pmid:13438883 |
TCHEN TT and BLOCH K | On the conversion of squalene to lanosterol in vitro. | 1957 | J. Biol. Chem. | pmid:13438881 |
STOKES WM | The separation of the compounds of the lanosterol group present in "isocholesterol" by chromatography of the p-iodobenzoates-I 131 and benzoates. | 1957 | Arch. Biochem. Biophys. | pmid:13425621 |
BLOCH K et al. | Isolation of lanosterol from isocholesterol. | 1957 | J. Biol. Chem. | pmid:13398397 |
BLOCH K et al. | Synthesis of lanosterol in vivo. | 1957 | J. Biol. Chem. | pmid:13398396 |
CLAYTON RB and BLOCH K | The biological conversion of lanosterol to cholesterol. | 1956 | J. Biol. Chem. | pmid:13278339 |
CLAYTON RB and BLOCH K | Biological synthesis of lanosterol and agnosterol. | 1956 | J. Biol. Chem. | pmid:13278338 |
Fon Tacer K et al. | Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation. | 2003 | J. Steroid Biochem. Mol. Biol. | pmid:12943732 |
Kamo T et al. | Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus. | 2003 | J. Nat. Prod. | pmid:12932134 |
de la Torre B et al. | Pathways of testosterone synthesis in decapsulated testes of mice. | 1976 | Acta Endocrinol. | pmid:128970 |
Lepesheva GI et al. | Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function. | 2003 | Biochemistry | pmid:12885242 |
Mo C et al. | In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity. | 2003 | Biochim. Biophys. Acta | pmid:12842197 |
Ohashi M et al. | Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. | 2003 | J. Biol. Chem. | pmid:12837764 |
Zheng YH et al. | Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12824470 |
Honda Y et al. | Revision and confirmation of the regiochemistry of isoxazoles derived from methyl oleanonate and lanost-8-en-3-one. Synthesis of a new lanostane triterpenoid with a cyano-enone functionality in ring A. | 2003 | J. Org. Chem. | pmid:12790619 |
Maurer-Stroh S et al. | Protein prenyltransferases. | 2003 | Genome Biol. | pmid:12702202 |