| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Neil HA et al. | Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: a randomised placebo controlled factorial trial. | 2010 | Atherosclerosis | pmid:21036355 |
| Relas H et al. | Dietary squalene increases cholesterol synthesis measured with serum non-cholesterol sterols after a single oral dose in humans. | 2000 | Atherosclerosis | pmid:10998465 |
| Fassbender K et al. | Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. | 2008 | Atherosclerosis | pmid:17137582 |
| Ranganathan S et al. | Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. | 1982 | Atherosclerosis | pmid:7150392 |
| Dull BJ et al. | The modulating effect of an inhibitor of cholesterolgenesis present in bovine milk upon the synthesis of cholesterol, dolichol and ubiquinone. | 1983 | Atherosclerosis | pmid:6661267 |
| Zhao LW et al. | Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24815470 |
| Rozenberg O et al. | Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615663 |
| Burkhardt R et al. | Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21252064 |
| Burgess B et al. | Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18599800 |
| Kojima M et al. | Altered gene expression of hepatic lanosterol 14alpha-demethylase (CYP51) in lead nitrate-treated rats. | 2002 | Arch. Toxicol. | pmid:12111004 |
| Sun B et al. | Two novel A-seco-rearranged lanostane triterpenoids from Abies sachalinensis. | 2008 | Arch. Pharm. Res. | pmid:19099219 |
| Wang W et al. | Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives. | 2009 | Arch. Pharm. (Weinheim) | pmid:19899102 |
| Clayton PT | Disorders of cholesterol biosynthesis. | 1998 | Arch. Dis. Child. | pmid:9579167 |
| Johnson RC and Shah SN | Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. | 1974 | Arch. Biochem. Biophys. | pmid:4460877 |
| Lepesheva GI et al. | Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET. | 2007 | Arch. Biochem. Biophys. | pmid:17585868 |
| Fryberg M et al. | Sterol biosynthesis in antibiotic sensitive and resistant Candida. | 1976 | Arch. Biochem. Biophys. | pmid:769695 |
| Debeljak N et al. | Many facets of mammalian lanosterol 14alpha-demethylase from the evolutionarily conserved cytochrome P450 family CYP51. | 2003 | Arch. Biochem. Biophys. | pmid:12464255 |
| Song MK and Dempsey ME | Requirement for a major soluble protein in the conversion of lanosterol to cholesterol by membrane-bound enzymes. | 1981 | Arch. Biochem. Biophys. | pmid:7305386 |
| Field RB and Holmlund CE | Isolation of 2,3;22,23-dioxidosqualene and 24,25-oxidolanosterol from yeast. | 1977 | Arch. Biochem. Biophys. | pmid:327938 |
| Nes WD et al. | Metabolism of 24(R,S),25-epiminolanosterol to 25-aminolanosterol and lanosterol by Gibberella fujikuroi. | 1989 | Arch. Biochem. Biophys. | pmid:2751307 |