MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Imai H et al. | Angiotoxicity of oxygenated sterols and possible precursors. | 1980 | Science | pmid:7352277 |
Aoyama Y and Yoshida Y | [Role of the microsomal electron-transport system in lanosterol demethylation (author's transl)]. | 1981 | Seikagaku | pmid:7320588 |
Dias JR and Gao H | 13C nuclear magnetic resonance data of lanosterol derivatives--profiling the steric topology of the steroid skeleton via substituent effects on its 13C NMR. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19800838 |
Mitropoulos KA et al. | Lanosterol 14alpha-demethylase. Similarity of the enzyme system from yeast and rat liver. | 1976 | Steroids | pmid:781918 |
Yding Andersen C and Byskov AG | Progesterone and 17 alpha-OH-progesterone in concentrations similar to that of preovulatory follicular fluid is without effect on resumption of meiosis in mouse cumulus enclosed oocytes cultured in the presence of hypoxanthine. | 2002 | Steroids | pmid:12398990 |
Bildziukevich U et al. | Amides derived from heteroaromatic amines and selected steryl hemiesters. | 2013 | Steroids | pmid:24145008 |
Nes WD et al. | Concerning the role of 24,25-dihydrolanosterol and lanostanol in sterol biosynthesis by cultured cells. | 1989 Mar-May | Steroids | pmid:2799854 |
Bühler H et al. | Endogenous inhibitors of 11 beta-OHSD: existence and possible significance. | 1994 | Steroids | pmid:8191542 |
Maitra US et al. | Biosynthetic preparation of labeled 4,4-dimethylzymosterol. | 1989 Mar-May | Steroids | pmid:2799859 |
Kavtaradze LK et al. | A low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures. | 2004 | Steroids | pmid:15465116 |
Visbal G et al. | Synthesis, in vitro antifungal activity and mechanism of action of four sterol hydrazone analogues against the dimorphic fungus Paracoccidioides brasiliensis. | Steroids | pmid:21605581 | |
Jeong TM et al. | Sterols from a species of Pichia, a n-alkane-utilizing yeast. | 1975 | Steroids | pmid:1154452 |
Nitchuk WM and Ainsworth L | The de novo synthesis of sterols and cholesterol from acetate-1- 14 C by sheep and pig placental and fetal liver slices in vitro. | 1972 | Steroids | pmid:5028884 |
Fakheri RJ and Javitt NB | 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. | 2012 | Steroids | pmid:22366074 |
Iglesias J and Gibbons GF | Oxidative metabolism of cholesterol precursors: sensitivity to ketoconazole, an inhibitor of cytochrome P-450. | 1989 Mar-May | Steroids | pmid:2799848 |
Kavtaradze LK et al. | Efficient routes to epimerically-pure side-chain derivatives of lanosterol. | 2004 | Steroids | pmid:15183688 |
Seo S et al. | Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. | 1993 | Steroids | pmid:8484187 |
Burstein S et al. | Specificity of the cholesterol side-chain cleavage enzyme system of adrenal cortex. | 1977 | Steroids | pmid:605455 |
Javitt NB | Oxysterols: novel biologic roles for the 21st century. | 2008 | Steroids | pmid:18068744 |
Lewis D et al. | Enzyme inhibition during the conversion of squalene to cholesterol. | 1995 | Steroids | pmid:7482633 |