| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smith AG and Goad LJ | Sterol biosynthesis by the sea urchin Echinus esculentus. | 1974 | Biochem. J. | pmid:4441383 |
| Iglesias J and Gibbons GF | Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol. | 1989 | Biochem. J. | pmid:2604729 |
| Lamb DC et al. | Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family. | 2002 | Biochem. J. | pmid:12023899 |
| Smith AG and Goad LJ | Sterol biosynthesis in the echinoderm Asterias rubens. | 1975 | Biochem. J. | pmid:1147897 |
| MARCUS S | Antibacterial activity of the triterpenoid acid (polyporenic acid C) and of ungulinic acid, metabolic products of Polyporus benzoinus (Wahl.) Fr. | 1952 | Biochem. J. | pmid:14925127 |
| Hitchcock CA et al. | Purification and properties of cytochrome P-450-dependent 14 alpha-sterol demethylase from Candida albicans. | 1989 | Biochem. J. | pmid:2556999 |
| Gibbons GF and Mitropoulos KA | The effect of carbon monoxide on the nature of the accumulated 4,4-dimethyl sterol precursors of cholesterol during its biosynthesis from (2-14C)mevalonic acid in vitro. | 1973 | Biochem. J. | pmid:4724584 |
| Gibbons GF and Mitropoulos KA | Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. | 1972 | Biochem. J. | pmid:5073750 |
| Bae S et al. | Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions. | 2001 | Biochem. J. | pmid:11171067 |
| Willett JD and Downey WL | Sterol biosynthesis in the free-living nematode Panagrellus redivivus. | 1974 | Biochem. J. | pmid:4822732 |
| Patkar P et al. | C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications. | 2013 | Biochem. J. | pmid:23984880 |
| Beastall GH et al. | Studies on phytosterol biosynthesis: metabolism of 24,25-dihydrolanosterol and cholesterol in Ochromonas malhamensis. | 1972 | Biochem. J. | pmid:5085559 |
| Nes CR et al. | Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. | 2012 | Biochem. J. | pmid:22176028 |
| Cabrito TR et al. | The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. | 2011 | Biochem. J. | pmid:21831043 |
| Bae SH and Paik YK | Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. | 1997 | Biochem. J. | pmid:9291139 |
| Wang CN et al. | The inhibition of human platelet function by ganodermic acids. | 1991 | Biochem. J. | pmid:1649599 |
| Derksen A et al. | Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo. | 1976 | Biochem. J. | pmid:822845 |
| Arce V et al. | A comparative study of the in vitro and in vivo formation of lanosterol derivatives from acetate by different chick tissues. | 1993 | Biochem. Mol. Biol. Int. | pmid:8330018 |
| Su CY et al. | Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets. | 1999 | Biochem. Pharmacol. | pmid:10413295 |
| Witkowski A et al. | Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes. | 1984 | Biochem. Pharmacol. | pmid:6546879 |