| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oliver BG et al. | cis-Acting elements within the Candida albicans ERG11 promoter mediate the azole response through transcription factor Upc2p. | 2007 | Eukaryotic Cell | pmid:17951521 |
| Hand RA et al. | Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. | 2003 | Eukaryotic Cell | pmid:12684380 |
| Joffrion TM et al. | Functional characterization and localization of Pneumocystis carinii lanosterol synthase. | 2010 | Eukaryotic Cell | pmid:19897737 |
| Xu J et al. | Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. | 2011 | Eur J Med Chem | pmid:21420761 |
| Che X et al. | New azoles with potent antifungal activity: design, synthesis and molecular docking. | 2009 | Eur J Med Chem | pmid:19539408 |
| Lange S et al. | Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors. | 2013 | Eur J Med Chem | pmid:23583910 |
| Yawata A et al. | Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. | 2009 | Eur J Pharm Sci | pmid:19748575 |
| Henriksen J et al. | Vesicle fluctuation analysis of the effects of sterols on membrane bending rigidity. | 2004 | Eur. Biophys. J. | pmid:15221234 |
| Phillips GT and Clifford KH | Stereochemistry of a methyl-group rearrangement during the biosynthesis of lanosterol. | 1976 | Eur. J. Biochem. | pmid:1245185 |
| Roberti R et al. | Cloning and expression of sterol Delta 14-reductase from bovine liver. | 2002 | Eur. J. Biochem. | pmid:11784322 |
| Parks LW et al. | Sterol transmethylation during aerobic adaptation of yeast. | 1974 | Eur. J. Biochem. | pmid:4598750 |
| Suárez Y et al. | Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription. | 2002 | Eur. J. Biochem. | pmid:11895447 |
| Zweytick D et al. | Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. | 2000 | Eur. J. Biochem. | pmid:10672016 |
| Rohmer M et al. | Non-specific lanosterol and hopanoid biosynthesis be a cell-free system from the bacterium Methylococcus capsulatus. | 1980 | Eur. J. Biochem. | pmid:6780348 |
| Gibbons GF and Mitropoulos KA | The rôle of cytochrome P-450 in cholesterol biosynthesis. | 1973 | Eur. J. Biochem. | pmid:4149283 |
| Pfaller M and Riley J | Effects of fluconazole on the sterol and carbohydrate composition of four species of Candida. | 1992 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:1396728 |
| Wang J and Wu J | Antifungal activity of 25-azalanosterol against Candida species. | 2008 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:18574605 |
| Pfaller M et al. | Effects of cilofungin (LY121019) on carbohydrate and sterol composition of Candida albicans. | 1989 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:2695329 |
| Mayr A and Lass-Flörl C | Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. | 2011 | Eur. J. Med. Res. | pmid:21486729 |
| Sandherr M and Maschmeyer G | Pharmacology and metabolism of voriconazole and Posaconazole in the treatment of invasive aspergillosis: review of the literature. | 2011 | Eur. J. Med. Res. | pmid:21486727 |
| Liu RM et al. | Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitro. | 2012 | Eur. J. Pharmacol. | pmid:22366428 |
| Lee JH et al. | Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes. | 2009 | Eur. J. Pharmacol. | pmid:19446542 |
| Passos GF et al. | The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. | 2013 | Eur. J. Pharmacol. | pmid:23099255 |
| Silbernagel G et al. | Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans. | 2012 | Exp Diabetes Res | pmid:22203835 |
| Gonzalez R et al. | Studies of sterol synthesis, synthesis regulation and transport in cultured human kidney. | 1974 | Exp. Cell Res. | pmid:4841900 |
| Chen JK et al. | Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. | 1986 | Exp. Cell Res. | pmid:3943557 |
| Fernández C et al. | Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation. | 2004 | Exp. Cell Res. | pmid:15383319 |
| Becker K et al. | Identification of a novel mutation in 3beta-hydroxysteroid-Delta8-Delta7-isomerase in a case of Conradi-Hünermann-Happle syndrome. | 2001 | Exp. Dermatol. | pmid:11493318 |
| Tiffany JM and Marsden RG | The meibomian lipids of the rabbit. II. Detailed composition of the principal esters. | 1982 | Exp. Eye Res. | pmid:7075715 |
| Wender M et al. | Free sterols in the rat white matter following experimental global ischemia. | 1997 | Exp. Toxicol. Pathol. | pmid:9085074 |
| Musaji N | Antifungal drug resistance: not all azoles are equal. | 2010 | Expert Rev Anti Infect Ther | pmid:20455680 |
| MartÃnez-Botas J et al. | Cholesterol starvation decreases p34(cdc2) kinase activity and arrests the cell cycle at G2. | 1999 | FASEB J. | pmid:10428760 |
| Wang N et al. | ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. | 2008 | FASEB J. | pmid:18039927 |
| Bennati AM et al. | Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. | 2008 | FEBS J. | pmid:18785926 |
| Astruc M et al. | The binding of squalene by human placental cytosol: role in conversion of squalene to lanosterol. | 1974 | FEBS Lett. | pmid:4426400 |
| Lamb DC et al. | Molecular diversity of sterol 14alpha-demethylase substrates in plants, fungi and humans. | 1998 | FEBS Lett. | pmid:9559662 |
| Ryder NS et al. | Inhibition of fungal and mammalian sterol biosynthesis by 2-aza-2,3-dihydrosqualene. | 1986 | FEBS Lett. | pmid:3525224 |
| Tabacik C et al. | The squalene epoxidase-cyclase activity of human term placenta. | 1973 | FEBS Lett. | pmid:4747843 |
| Soustre I et al. | Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae. | 2000 | FEBS Lett. | pmid:10734216 |
| Li X et al. | Multiple effects of a novel compound from Burkholderia cepacia against Candida albicans. | 2008 | FEMS Microbiol. Lett. | pmid:18565124 |
| Valachovic M et al. | Anaerobiosis induces complex changes in sterol esterification pattern in the yeast Saccharomyces cerevisiae. | 2001 | FEMS Microbiol. Lett. | pmid:11287144 |
| Barrett-Bee K et al. | Biochemical changes associated with the antifungal action of the triazole ICI 153,066 on Candida albicans and Trichophyton quinckeanum. | 1991 | FEMS Microbiol. Lett. | pmid:2060756 |
| Hronská L et al. | Low concentrations of the non-ionic detergent Nonidet P-40 interfere with sterol biogenesis and viability of the yeast Saccharomyces cerevisiae. | 2004 | FEMS Microbiol. Lett. | pmid:15336428 |
| Koukkou AI et al. | Effect of ethanol on the sterols of the fission yeast Schizosaccharomyces pombe. | 1993 | FEMS Microbiol. Lett. | pmid:8405927 |
| Harmouch N et al. | Identification of 24-methylene-24,25-dihydrolanosterol as a precursor of ergosterol in the yeasts Schizosaccharomyces pombe and Schizosaccharomyces octosporus. | 1995 | FEMS Microbiol. Lett. | pmid:8586261 |
| Rosa Ide A et al. | Ultrastructural alterations induced by Δ(24(25))-sterol methyltransferase inhibitors on Trichomonas vaginalis. | 2011 | FEMS Microbiol. Lett. | pmid:21175744 |
| Bean TP et al. | Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides. | 2009 | FEMS Microbiol. Lett. | pmid:19459949 |
| Venkateswarlu K et al. | Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug. | 1995 | FEMS Microbiol. Lett. | pmid:7557345 |
| Hajjaj H et al. | Aspergillus oryzae produces compounds inhibiting cholesterol biosynthesis downstream of dihydrolanosterol. | 2005 | FEMS Microbiol. Lett. | pmid:15621432 |
| Kim D et al. | Functional expression and characterization of CYP51 from dandruff-causing Malassezia globosa. | 2011 | FEMS Yeast Res. | pmid:21114623 |