MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Marco de la Calle C et al. | A relationship between the activities of hepatic lanosterol 14 alpha-demethylase and 3-hydroxy-3-methylglutaryl-CoA reductase. | 1988 | Biochem. J. | pmid:3355520 |
Barrett-Bee K et al. | Biochemical studies with a novel antifungal agent, ICI 195,739. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3063170 |
Aoyama Y et al. | 7-Oxo-24,25-dihydrolanosterol: a novel lanosterol 14 alpha-demethylase (P-45014DM) inhibitor which blocks electron transfer to the oxyferro intermediate. | 1987 | Biochim. Biophys. Acta | pmid:3318933 |
Bard M et al. | Characterization of a cytochrome P450 deficient mutant of Candida albicans. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3307785 |
Tabacik C et al. | Regulation of cholesterol biosynthesis at a stage after the 3-hydroxy-3-methylglutaryl-CoA reductase step, in normal and leukemic (L2C) guinea pig lymphocytes. | 1987 | Biochim. Biophys. Acta | pmid:3651496 |
M'Baya B and Karst F | In vitro assay of squalene epoxidase of Saccharomyces cerevisiae. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3307781 |
Favata MF et al. | Modulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by azole antimycotics requires lanosterol demethylation, but not 24,25-epoxylanosterol formation. | 1987 | J. Biol. Chem. | pmid:3624255 |
Trzaskos JM et al. | In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. | 1987 | J. Biol. Chem. | pmid:3624256 |
Lange Y and Muraski MF | Cholesterol is not synthesized in membranes bearing 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1987 | J. Biol. Chem. | pmid:3558346 |
Reinhart MP et al. | Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver. | 1987 | J. Biol. Chem. | pmid:3597431 |