lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with lanosterol

Download all related citations
Per page 10 20 50 100 | Total 1125
Authors Title Published Journal PubMed Link
Johnson RC and Shah SN Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. 1976 Lipids pmid:994754
Martínez-Botas J et al. Induction of apoptosis in p53-null HL-60 cells by inhibition of lanosterol 14-alpha demethylase. 1998 Biochimie pmid:9893947
Kaneshiro ES et al. Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874778
Jayasuriya H et al. Clavaric acid: a triterpenoid inhibitor of farnesyl-protein transferase from Clavariadelphus truncatus. 1998 J. Nat. Prod. pmid:9868169
Lingham RB et al. Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase. 1998 J. Med. Chem. pmid:9804689
Takahira M et al. Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp. 1998 Biol. Pharm. Bull. pmid:9743250
Aboushadi N and Krisans SK Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. 1998 J. Lipid Res. pmid:9741690
Urbina JA et al. A carbon-13 nuclear magnetic resonance spectroscopic study of inter-proton pair order parameters: a new approach to study order and dynamics in phospholipid membrane systems. 1998 Biophys. J. pmid:9726938
Cho SY et al. Cholesterol biosynthesis from lanosterol: differential inhibition of sterol delta 8-isomerase and other lanosterol-converting enzymes by tamoxifen. 1998 Mol. Cells pmid:9638657
Safe S and Caldwell J In vitro binding of sterols by extracts from Mucor rouxii cells grown under different environmental conditions. 1976 Can. J. Microbiol. pmid:963628
Sajbidor J et al. Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. 1998 J. Pharm. Pharmacol. pmid:9600722
Clayton PT Disorders of cholesterol biosynthesis. 1998 Arch. Dis. Child. pmid:9579167
Saat YA and Bloch KE Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase. 1976 J. Biol. Chem. pmid:956181
Lamb DC et al. Molecular diversity of sterol 14alpha-demethylase substrates in plants, fungi and humans. 1998 FEBS Lett. pmid:9559662
Casali AK and Hamdan JS Effects of three azole derivatives on the lipids of different strains of Sporothrix schenckii. 1997 Can. J. Microbiol. pmid:9476355
Nes WD et al. Sterol utilization and metabolism by Heliothis zea. 1997 Lipids pmid:9438243
Bianchi C et al. Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life. 1997 J. Pediatr. pmid:9427904
Solaja BA et al. The synthesis and in vitro activity of some delta 7,9(11)-lanostadienes. 1997 Steroids pmid:9366010
Gachotte D et al. A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9326581
Bae SH and Paik YK Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. 1997 Biochem. J. pmid:9291139
Koyama K et al. Antinociceptive components of Ganoderma lucidum. 1997 Planta Med. pmid:9225603
Morand OH et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. 1997 J. Lipid Res. pmid:9162756
Contreras LM et al. Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors. 1997 Biochem. Pharmacol. pmid:9113089
Wender M et al. Free sterols in the rat white matter following experimental global ischemia. 1997 Exp. Toxicol. Pathol. pmid:9085074
Miettinen TE et al. The effects of ursodeoxycholic acid on serum and biliary noncholesterol sterols in patients with gallstones. 1997 Hepatology pmid:9049189
Cabello-Hurtado F et al. Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14alpha-demethylase (CYP51) in wheat. 1997 Biochem. Biophys. Res. Commun. pmid:9016788
Tavares IA et al. The pathway for the conversion of dihydroagnosterol into cholesterol in rat liver. 1977 Biochem. J. pmid:901410
Krisans SK Cell compartmentalization of cholesterol biosynthesis. 1996 Ann. N. Y. Acad. Sci. pmid:8993542
Itoh T et al. Occurrence of lanosterol and lanostenol in seeds of red pepper (Capsicum annuum). 1977 Steroids pmid:898228
Kaneshiro ES et al. Identification of C31 and C32 sterols in Pneumocystis carinii hominis-infected human lungs. 1996 Sep-Oct J. Eukaryot. Microbiol. pmid:8822839
Urbina JA et al. Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. 1996 Jul-Aug Chemotherapy pmid:8804798
Yoshida Y et al. Sterol 14-demethylase P450 activity expressed in rat gonads: contribution to the formation of mammalian meiosis-activating sterol. 1996 Biochem. Biophys. Res. Commun. pmid:8687430
Berkhout TA et al. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1996 J. Biol. Chem. pmid:8662919
Tint GS and Salen G Evidence for the early reduction of the 24,25 double bond in the conversion of lanosterol to cholesterol in cerebrotendinous xanthomatosis. 1977 Metab. Clin. Exp. pmid:865281
van Nistelrooy JG et al. Isolation and molecular characterisation of the gene encoding eburicol 14 alpha-demethylase (cYP51) from Penicillium italicum. 1996 Mol. Gen. Genet. pmid:8628233
Shi J et al. Identification and characterization of an S-adenosyl-L-methionine: delta 24-sterol-C-methyltransferase cDNA from soybean. 1996 J. Biol. Chem. pmid:8621604
Sekigawa Y et al. Purification and characterization of a cytochrome P450 isozyme catalyzing lanosterol 14 alpha-demethylation (P45014DM) in hamster liver. 1995 Lipids pmid:8614296
Harmouch N et al. Identification of 24-methylene-24,25-dihydrolanosterol as a precursor of ergosterol in the yeasts Schizosaccharomyces pombe and Schizosaccharomyces octosporus. 1995 FEMS Microbiol. Lett. pmid:8586261
Astruc M et al. Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues. 1977 Biochim. Biophys. Acta pmid:857899
Arneborg N et al. The effect of ethanol and specific growth rate on the lipid content and composition of Saccharomyces cerevisiae grown anaerobically in a chemostat. 1995 Yeast pmid:8533470
Franzot SP and Hamdan JS Effects of three azole derivatives on the lipids of different strains of Cryptococcus neoformans. 1995 May-Jun Mycoses pmid:8531929
Seo S et al. Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. 1993 Steroids pmid:8484187
Koukkou AI et al. Effect of ethanol on the sterols of the fission yeast Schizosaccharomyces pombe. 1993 FEMS Microbiol. Lett. pmid:8405927
Sonoda Y et al. Purification of a human cytochrome P-450 isozyme catalyzing lanosterol 14 alpha-demethylation. 1993 Biochim. Biophys. Acta pmid:8399332
Arce V et al. A comparative study of the in vitro and in vivo formation of lanosterol derivatives from acetate by different chick tissues. 1993 Biochem. Mol. Biol. Int. pmid:8330018
Mercer EI Inhibitors of sterol biosynthesis and their applications. 1993 Prog. Lipid Res. pmid:8309949
Vanden Bossche H et al. Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. 1993 Antimicrob. Agents Chemother. pmid:8257130
Derksen A et al. Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo. 1976 Biochem. J. pmid:822845
Bühler H et al. Endogenous inhibitors of 11 beta-OHSD: existence and possible significance. 1994 Steroids pmid:8191542
Buttke TM and Van Cleave S Adaptation of a cholesterol deficient human T cell line to growth with lanosterol. 1994 Biochem. Biophys. Res. Commun. pmid:8166689
Leonard DA et al. Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 3 beta-hydroxy-lanost-8-en-32-al, an intermediate in the conversion of lanosterol to cholesterol. 1994 Arch. Biochem. Biophys. pmid:8161198
Mimaki Y et al. Lanosterol oligosaccharides from the plants of the subfamily Scilloideae and their antitumor-promoter activity. 1994 Chem. Pharm. Bull. pmid:8149459
Hashimoto F and Hayashi H Peroxisomal cholesterol synthesis in vivo: accumulation of 4-methyl intermediate sterols after aminotriazole inhibition of cholesterol synthesis. 1994 Biochim. Biophys. Acta pmid:8068723
Fujimoto H et al. Isolation and characterization of immunosuppressive components of three mushrooms, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina. 1994 Chem. Pharm. Bull. pmid:8004718
Frye LL et al. Oxolanosterol oximes: dual-action inhibitors of cholesterol biosynthesis. 1994 J. Lipid Res. pmid:7989858
Izumi A et al. Inhibitors of sterol synthesis. Submicromolar 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol causes a major modification of the sterol composition of CHO-K1 cells and a marked change in cell morphology. 1994 J. Lipid Res. pmid:7964186
Boutaud O et al. Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. 1995 Biochem. Biophys. Res. Commun. pmid:7887959
Anderson JA et al. 15-substituted lanosterols: post-transcriptional suppressors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1995 Arch. Biochem. Biophys. pmid:7840615
Mitropoulos KA et al. Lanosterol 14alpha-demethylase. Similarity of the enzyme system from yeast and rat liver. 1976 Steroids pmid:781918
Abe I and Prestwich GD Identification of the active site of vertebrate oxidosqualene cyclase. 1995 Lipids pmid:7791531
Lees ND et al. Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. 1995 Lipids pmid:7791529
Abuelo DN et al. Prenatal detection of the cholesterol biosynthetic defect in the Smith-Lemli-Opitz syndrome by the analysis of amniotic fluid sterols. 1995 Am. J. Med. Genet. pmid:7778590
Kerr RG and Chen Z In vivo and in vitro biosynthesis of saponins in sea cucumbers. 1995 J. Nat. Prod. pmid:7769386
Mimaki Y et al. Lanosterol and 27-norlanosterol oligosaccharides from the bulbs of Chionodoxa gigantea. 1993 Phytochemistry pmid:7764152
Fryberg M et al. Sterol biosynthesis in antibiotic sensitive and resistant Candida. 1976 Arch. Biochem. Biophys. pmid:769695
Trzaskos JM et al. Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis. 1993 J. Biol. Chem. pmid:7693673
Trzaskos JM et al. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: II. Time-dependent enzyme inactivation by selected oxylanosterol analogs. 1995 Biochemistry pmid:7626637
Kang MK et al. Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 8-isomerase. 1995 J. Biochem. pmid:7592544
Venkateswarlu K et al. Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug. 1995 FEMS Microbiol. Lett. pmid:7557345
Koeda M et al. Studies on the Chinese crude drug "shoma." IX. Three novel cyclolanostanol xylosides, cimicifugosides H-1, H-2 and H-5, from cimicifuga rhizome. 1995 Chem. Pharm. Bull. pmid:7553963
Urbina JA et al. Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparative study using 2H-, 13C- and 31P-NMR spectroscopy. 1995 Biochim. Biophys. Acta pmid:7548131
Takei M et al. Mechanism of inhibition of IgE-dependent histamine release from rat mast cells by penasterol and penasterone. 1995 J Pharm Sci pmid:7537812
Kim CK et al. Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 14-reductase. 1995 Biochim. Biophys. Acta pmid:7492613
Lewis D et al. Enzyme inhibition during the conversion of squalene to cholesterol. 1995 Steroids pmid:7482633
Trzaskos JM Oxylanosterols as modifiers of cholesterol biosynthesis. 1995 Prog. Lipid Res. pmid:7480066
Dahl JS et al. Effect of cholesterol on macromolecular synthesis and fatty acid uptake by Mycoplasma capricolum. 1981 J. Biol. Chem. pmid:7451451
Emmons GT et al. 20,25-Diazacholesterol, clofibric acid and 2,4-dichlorophenoxyacetic acid--all inducers of myotonia--perturb the post-lanosterol sector of sterol biosynthesis in cultured chick embryo fibroblasts. 1980 Biochem. Biophys. Res. Commun. pmid:7437038
Ciavatti M et al. Oral contraceptives, lanosterol, and platelet hyperactivity in rat. 1980 Science pmid:7433990
Gibbons GF et al. Metabolism of hydroxy sterols by rat liver. 1980 Biochim. Biophys. Acta pmid:7417472
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Noland BJ et al. Purification and properties of sterol carrier protein2. 1980 J. Biol. Chem. pmid:7372677
Dahl CE et al. Effects of cycloartenol and lanosterol on artificial and natural membranes. 1980 Biochem. Biophys. Res. Commun. pmid:7356454
Imai H et al. Angiotoxicity of oxygenated sterols and possible precursors. 1980 Science pmid:7352277
Aoyama Y and Yoshida Y [Role of the microsomal electron-transport system in lanosterol demethylation (author's transl)]. 1981 Seikagaku pmid:7320588
Tabacik C et al. Post-HMG CoA reductase regulation of cholesterol biosynthesis in normal human lymphocytes : lanosten-3 betal-ol-32-al, a natural inhibitor. 1981 Biochem. Biophys. Res. Commun. pmid:7306125
Song MK and Dempsey ME Requirement for a major soluble protein in the conversion of lanosterol to cholesterol by membrane-bound enzymes. 1981 Arch. Biochem. Biophys. pmid:7305386
Parish EJ and Schroepfer GJ Sterol synthesis. A simplified method for the synthesis of 32-oxygenated derivatives of 24,25-dihydrolanosterol. 1981 J. Lipid Res. pmid:7288292
Hemmi H and Ishida N The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. 1980 J. Pharmacobio-dyn. pmid:7277179
Hemmi H et al. Selective inhibition of nucleoside transport into mouse lymphoma L-5178Y cells by cimicfugoside. 1980 J. Pharmacobio-dyn. pmid:7277178
Fukushima H et al. Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase. 1981 J. Biol. Chem. pmid:7228857
Burns CP et al. Mechanism of defective sterol synthesis in human leukocytes. 1982 Biochim. Biophys. Acta pmid:7150625
Ranganathan S et al. Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. 1982 Atherosclerosis pmid:7150392
Maugh TH Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. 1982 Science pmid:7146911
Ciavatti M et al. Biosynthesis of platelet lipids in relation to aggregation in women using oral contraceptives. 1982 Contraception pmid:7116849
Tint GS and Salen G Biosynthesis of cholesterol, lanosterol, and delta 7-cholestenol, but not cholestanol, in cultured fibroblasts from normal individuals and patients with cerebrotendinous xanthomatosis. 1982 J. Lipid Res. pmid:7097124
Carson DD et al. Synthesis of steroids in postimplantation mouse embryos cultured in vitro. 1982 Dev. Biol. pmid:7095272
Sato Y and Sonoda Y [Metabolism of 27-nor-24,25-dihydrolanosterol and 23,24,25,26,27-pentanordihydrolanosterol by rat liver homogenate preparations]. 1982 Chem. Pharm. Bull. pmid:7094149
Wiss O and Wiss V The degradation of labelled lanosterol by homogenate of rat liver: evidence for the formation of lithocholic acid from lanosterol without cholesterol as intermediate. 1978 Biochem. Biophys. Res. Commun. pmid:708435
Tiffany JM and Marsden RG The meibomian lipids of the rabbit. II. Detailed composition of the principal esters. 1982 Exp. Eye Res. pmid:7075715
Berry DJ and Chang TY Further characterization of a Chinese hamster ovary cell mutant defective in lanosterol demethylation. 1982 Biochemistry pmid:7066308