| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Chong CR et al. | Inhibition of angiogenesis by the antifungal drug itraconazole. | 2007 | ACS Chem. Biol. | pmid:17432820 |
| Noel JP et al. | Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. | 2010 | ACS Chem. Biol. | pmid:20175559 |
| Wang N et al. | N-Cyclo-propyl-N-[2-(2,4-difluoro-phen-yl)-2-hy-droxy-1-(1H-1,2,4-triazol-1-yl)prop-yl]-2-(5-methyl-2,4-dioxo-1,2,3,4-tetra-hydro-pyrimidin-1-yl)acetamide dichloro-methane 0.62-solvate. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22059025 |
| de la Torre B et al. | Pathways of testosterone synthesis in decapsulated testes of mice. | 1976 | Acta Endocrinol. | pmid:128970 |
| Edgren B and Hellström K | Lipid biosynthesis from DL (2- 14 C) mevalonic acid in intact mice and rabbits. | 1972 | Acta Physiol. Scand. | pmid:4640173 |
| Wang CN et al. | The effect of ganodermic acid S on human platelets. | 1990 | Adv. Exp. Med. Biol. | pmid:1966354 |
| Herman GE and Kratz L | Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome. | 2012 | Am J Med Genet C Semin Med Genet | pmid:23042573 |
| Leichtle AB et al. | Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men. | 2011 | Am. J. Clin. Nutr. | pmid:21940598 |
| Abuelo DN et al. | Prenatal detection of the cholesterol biosynthetic defect in the Smith-Lemli-Opitz syndrome by the analysis of amniotic fluid sterols. | 1995 | Am. J. Med. Genet. | pmid:7778590 |
| Andersson HC et al. | Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. | 2002 | Am. J. Med. Genet. | pmid:12457401 |
| Kelley RI et al. | Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia. | 2002 | Am. J. Med. Genet. | pmid:12116245 |
| Cragun DL et al. | Undetectable maternal serum uE3 and postnatal abnormal sterol and steroid metabolism in Antley-Bixler syndrome. | 2004 | Am. J. Med. Genet. A | pmid:15266606 |
| Adachi M et al. | Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome. | 2004 | Am. J. Med. Genet. A | pmid:15264278 |
| Baardman ME et al. | The origin of fetal sterols in second-trimester amniotic fluid: endogenous synthesis or maternal-fetal transport? | 2012 | Am. J. Obstet. Gynecol. | pmid:22728028 |
| Cai SY et al. | The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17567710 |
| Pietila MP et al. | Cloning and characterization of CYP51 from Mycobacterium avium. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16543605 |
| Morales IJ et al. | Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12606318 |
| Domeño C et al. | Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID. | 2005 | Anal Bioanal Chem | pmid:15827725 |
| Toh TH et al. | Quantification of plasma membrane ergosterol of Saccharomyces cerevisiae by direct-injection atmospheric pressure chemical ionization/tandem mass spectrometry. | 2001 | Anal. Biochem. | pmid:11141305 |
| Sun S et al. | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15582556 |
| Lu B et al. | Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. | 2007 | Anal. Chim. Acta | pmid:17386793 |
| Büdefeld T et al. | Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes. | 2009 | Anat Histol Embryol | pmid:19793088 |
| Kwok Y et al. | A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. | 2005 | Anesth. Analg. | pmid:16037156 |
| Chen N et al. | Biosynthetic Mechanism of Lanosterol: Cyclization. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26069216 |
| Marco-Jiménez F et al. | Effects of lanosterol on in vitro maturation of porcine oocytes. | 2010 | Anim. Reprod. Sci. | pmid:19473792 |
| Cooper AB et al. | Synthesis and antifungal properties of 14-aminomethyl-substituted lanosterol derivatives. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3214062 |
| Krisans SK | Cell compartmentalization of cholesterol biosynthesis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993542 |
| Gaylor JL and Delwiche CV | Investigation of the multienzymic system of microsomal cholesterol biosynthesis. | 1973 | Ann. N. Y. Acad. Sci. | pmid:4532473 |
| Stocker A | Molecular mechanisms of vitamin E transport. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753133 |
| Barrett-Bee K et al. | Biochemical studies with a novel antifungal agent, ICI 195,739. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3063170 |
| Schroepfer GJ | Sterol biosynthesis. | 1982 | Annu. Rev. Biochem. | pmid:6810750 |
| Ruzicka L | In the borderland between bioorganic chemistry and biochemistry. | 1973 | Annu. Rev. Biochem. | pmid:4600996 |
| Nomura M et al. | Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. | 2008 Sep-Oct | Anticancer Res. | pmid:19035296 |
| Parker JE et al. | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. | 2008 | Antimicrob. Agents Chemother. | pmid:18694951 |
| Van den Bossche H et al. | In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. | 1980 | Antimicrob. Agents Chemother. | pmid:6250469 |
| Warrilow AG et al. | The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. | 2016 | Antimicrob. Agents Chemother. | pmid:27161631 |
| Sagatova AA et al. | Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase. | 2015 | Antimicrob. Agents Chemother. | pmid:26055382 |
| Buurman ET et al. | Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds. | 2005 | Antimicrob. Agents Chemother. | pmid:15917573 |
| Kaneshiro ES et al. | Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. | 2000 | Antimicrob. Agents Chemother. | pmid:10817720 |
| Warrilow AG et al. | S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole. | 2012 | Antimicrob. Agents Chemother. | pmid:22252802 |
| Warrilow AG et al. | Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. | 2013 | Antimicrob. Agents Chemother. | pmid:23274672 |
| Vanden Bossche H et al. | Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. | 1993 | Antimicrob. Agents Chemother. | pmid:8257130 |
| Warrilow AG et al. | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. | 2010 | Antimicrob. Agents Chemother. | pmid:20660663 |
| Sud IJ and Feingold DS | Heterogeneity of action of mechanisms among antimycotic imidazoles. | 1981 | Antimicrob. Agents Chemother. | pmid:6269485 |
| Price CL et al. | Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. | 2015 | Appl. Environ. Microbiol. | pmid:25746994 |
| Parker JE et al. | Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals. | 2011 | Appl. Environ. Microbiol. | pmid:21169436 |
| Hajjaj H et al. | Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors. | 2005 | Appl. Environ. Microbiol. | pmid:16000773 |
| Xu JW et al. | Biotechnological production and application of ganoderic acids. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20437236 |
| Liang CX et al. | Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20077112 |