lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with lanosterol

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Authors Title Published Journal PubMed Link
Tabacik C et al. Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. 1975 Biochim. Biophys. Acta pmid:1236745
Endress E et al. Anisotropic motion and molecular dynamics of cholesterol, lanosterol, and ergosterol in lecithin bilayers studied by quasi-elastic neutron scattering. 2002 Biochemistry pmid:12390036
Yding Andersen C and Byskov AG Progesterone and 17 alpha-OH-progesterone in concentrations similar to that of preovulatory follicular fluid is without effect on resumption of meiosis in mouse cumulus enclosed oocytes cultured in the presence of hypoxanthine. 2002 Steroids pmid:12398990
Kaneshiro ES Is Pneumocystis a plant? 2002 Sep-Oct J. Eukaryot. Microbiol. pmid:12425523
Wada S et al. Triterpenoid constituents isolated from the bark of Abies sachalinensis. 2002 J. Nat. Prod. pmid:12444693
Phillips GT and Clifford KH Stereochemistry of a methyl-group rearrangement during the biosynthesis of lanosterol. 1976 Eur. J. Biochem. pmid:1245185
Andersson HC et al. Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. 2002 Am. J. Med. Genet. pmid:12457401
Niimi M et al. Identification of two proteins induced by exposure of the pathogenic fungus Candida glabrata to fluconazole. 2002 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12458010
Debeljak N et al. Many facets of mammalian lanosterol 14alpha-demethylase from the evolutionarily conserved cytochrome P450 family CYP51. 2003 Arch. Biochem. Biophys. pmid:12464255
Segura MJ et al. Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis. 2002 Org. Lett. pmid:12465912