| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miettinen TE et al. | The effects of ursodeoxycholic acid on serum and biliary noncholesterol sterols in patients with gallstones. | 1997 | Hepatology | pmid:9049189 |
| Wender M et al. | Free sterols in the rat white matter following experimental global ischemia. | 1997 | Exp. Toxicol. Pathol. | pmid:9085074 |
| Contreras LM et al. | Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors. | 1997 | Biochem. Pharmacol. | pmid:9113089 |
| Morand OH et al. | Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. | 1997 | J. Lipid Res. | pmid:9162756 |
| Koyama K et al. | Antinociceptive components of Ganoderma lucidum. | 1997 | Planta Med. | pmid:9225603 |
| Bae SH and Paik YK | Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. | 1997 | Biochem. J. | pmid:9291139 |
| Gachotte D et al. | A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9326581 |
| Solaja BA et al. | The synthesis and in vitro activity of some delta 7,9(11)-lanostadienes. | 1997 | Steroids | pmid:9366010 |
| Bianchi C et al. | Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life. | 1997 | J. Pediatr. | pmid:9427904 |
| Nes WD et al. | Sterol utilization and metabolism by Heliothis zea. | 1997 | Lipids | pmid:9438243 |
| Casali AK and Hamdan JS | Effects of three azole derivatives on the lipids of different strains of Sporothrix schenckii. | 1997 | Can. J. Microbiol. | pmid:9476355 |
| Lamb DC et al. | Molecular diversity of sterol 14alpha-demethylase substrates in plants, fungi and humans. | 1998 | FEBS Lett. | pmid:9559662 |
| Saat YA and Bloch KE | Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase. | 1976 | J. Biol. Chem. | pmid:956181 |
| Clayton PT | Disorders of cholesterol biosynthesis. | 1998 | Arch. Dis. Child. | pmid:9579167 |
| Sajbidor J et al. | Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. | 1998 | J. Pharm. Pharmacol. | pmid:9600722 |
| Safe S and Caldwell J | In vitro binding of sterols by extracts from Mucor rouxii cells grown under different environmental conditions. | 1976 | Can. J. Microbiol. | pmid:963628 |
| Cho SY et al. | Cholesterol biosynthesis from lanosterol: differential inhibition of sterol delta 8-isomerase and other lanosterol-converting enzymes by tamoxifen. | 1998 | Mol. Cells | pmid:9638657 |
| Urbina JA et al. | A carbon-13 nuclear magnetic resonance spectroscopic study of inter-proton pair order parameters: a new approach to study order and dynamics in phospholipid membrane systems. | 1998 | Biophys. J. | pmid:9726938 |
| Aboushadi N and Krisans SK | Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. | 1998 | J. Lipid Res. | pmid:9741690 |
| Takahira M et al. | Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp. | 1998 | Biol. Pharm. Bull. | pmid:9743250 |
| Lingham RB et al. | Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase. | 1998 | J. Med. Chem. | pmid:9804689 |
| Jayasuriya H et al. | Clavaric acid: a triterpenoid inhibitor of farnesyl-protein transferase from Clavariadelphus truncatus. | 1998 | J. Nat. Prod. | pmid:9868169 |
| Kaneshiro ES et al. | Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874778 |
| MartÃnez-Botas J et al. | Induction of apoptosis in p53-null HL-60 cells by inhibition of lanosterol 14-alpha demethylase. | 1998 | Biochimie | pmid:9893947 |
| Johnson RC and Shah SN | Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. | 1976 | Lipids | pmid:994754 |