MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Nagai J et al. | Effects of thiamine and pyridoxine on the content and composition of sterols in Saccharomyces carlsbergensis 4228. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4418731 |
Alexander KT et al. | A possible role for cytochrome P-450 during the biosynthesis of zymosterol from lanosterol by Saccharomyces cerevisiae. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4609128 |
Karst F and Lacroute F | Yeast mutant requiring only a sterol as growth supplement. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4601817 |
Cabello-Hurtado F et al. | Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14alpha-demethylase (CYP51) in wheat. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9016788 |
Trocha PJ et al. | Novel sterols in ergosterol deficient yeast mutants. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4604829 |
Aoyama Y and Yoshida Y | Interaction of lanosterol to cytochrome P-450 purified from yeast microscomes: evidence for contribution of cytochrome P-450 to lanosterol metabolism. | 1978 | Biochem. Biophys. Res. Commun. | pmid:27189 |
Aoyama Y and Yoshida Y | The 14alpha-demethylation of lanosterol by a reconstituted cytochrome P-450 system from yeast microsomes. | 1978 | Biochem. Biophys. Res. Commun. | pmid:105731 |
Kimura M et al. | Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19951700 |
Maitra US et al. | Purification of a terminal oxygenase in demethylation of C-30 of lanosterol. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6816234 |
Nes WD et al. | Control of fungal sterol C-24 transalkylation: importance to developmental regulation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3767970 |