| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dai J et al. | Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum. | 2017 | Oncotarget | pmid:28099150 |
| Cao FR et al. | Plasma and brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC-MS/MS method. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28346885 |
| Zhang DH et al. | Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi. | 2017 | Phytochemistry | pmid:27894599 |
| Zhang G et al. | Ethylene promotes mycelial growth and ganoderic acid biosynthesis in Ganoderma lucidum. | 2017 | Biotechnol. Lett. | pmid:27771819 |
| Katja DG et al. | Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae). | 2017 | J Asian Nat Prod Res | pmid:27329305 |
| Kim JW et al. | Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. | 2016 | Int J Mol Sci | pmid:27801787 |
| Wang XL et al. | Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi. | 2016 | Molecules | pmid:27775633 |
| Schrack S et al. | Oxysterols in cosmetics-Determination by planar solid phase extraction and gas chromatography-mass spectrometry. | 2016 | J Chromatogr A | pmid:28314390 |
| Suarez-Medellin J et al. | In Silico Analysis of Lanostanoids Characterized in Ganoderma Mushrooms (Agaricomycetes) as Potential Ligands of the Vitamin D Receptor. | 2016 | Int J Med Mushrooms | pmid:28008815 |
| Lai KH et al. | Cytotoxic Lanostanoids from Poria cocos. | 2016 | J. Nat. Prod. | pmid:27808511 |
| Hongthong S et al. | Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae). | 2016 | Bioorg. Med. Chem. Lett. | pmid:27793565 |
| Hu ZX et al. | Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea. | 2016 | J. Nat. Prod. | pmid:27704807 |
| Li HJ et al. | Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum. | 2016 | J. Biotechnol. | pmid:27080449 |
| Amen YM et al. | Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells. | 2016 | J Nat Med | pmid:26899240 |
| Isaka M et al. | Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganoderma sp. BCC 16642. | 2016 | J. Nat. Prod. | pmid:26716912 |
| Qiu J et al. | Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum. | 2016 | Fitoterapia | pmid:26709153 |
| Lee S et al. | Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. | 2016 | Theriogenology | pmid:26494176 |
| OuYang Q et al. | Transcriptional profiling analysis of Penicillium digitatum, the causal agent of citrus green mold, unravels an inhibited ergosterol biosynthesis pathway in response to citral. | 2016 | BMC Genomics | pmid:27514516 |
| Novack GD | Eyes on New Product Development. | 2016 | J Ocul Pharmacol Ther | pmid:27058691 |
| AÄimoviÄ J et al. | Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis. | 2016 | Sci Rep | pmid:27334049 |