| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnson RC and Shah SN | Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. | 1974 | Arch. Biochem. Biophys. | pmid:4460877 |
| Nagai J et al. | Effects of thiamine and pyridoxine on the content and composition of sterols in Saccharomyces carlsbergensis 4228. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4418731 |
| Alexander KT et al. | A possible role for cytochrome P-450 during the biosynthesis of zymosterol from lanosterol by Saccharomyces cerevisiae. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4609128 |
| Nikkari T et al. | In vivo studies of sterol and squalene secretion by human skin. | 1974 | J. Lipid Res. | pmid:4430879 |
| Smith AG and Goad LJ | Sterol biosynthesis by the sea urchin Echinus esculentus. | 1974 | Biochem. J. | pmid:4441383 |
| Astruc M et al. | The binding of squalene by human placental cytosol: role in conversion of squalene to lanosterol. | 1974 | FEBS Lett. | pmid:4426400 |
| Ramsey RB and Davison AN | Steryl esters and their relationship to normal and diseased human central nervous system. | 1974 | J. Lipid Res. | pmid:4363969 |
| Parks LW et al. | Sterol transmethylation during aerobic adaptation of yeast. | 1974 | Eur. J. Biochem. | pmid:4598750 |
| Fryberg M et al. | Sterol biosynthesis in antibiotic-resistant yeast: nystatin. | 1974 | Arch. Biochem. Biophys. | pmid:4597559 |
| Karst F and Lacroute F | Yeast mutant requiring only a sterol as growth supplement. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4601817 |
| Trocha PJ et al. | Novel sterols in ergosterol deficient yeast mutants. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4604829 |
| Gollub EG et al. | Yeast mutants requiring ergosterol as only lipid supplement. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4363054 |
| Nes WR | Role of sterols in membranes. | 1974 | Lipids | pmid:4607429 |
| Fetizon M et al. | New routes for the degradation of the lanosterol side chain. | 1974 | J. Org. Chem. | pmid:4853345 |
| Ganem B and Kellogg MS | Improved methods for the side-chain degradation of lanosterol. The synthesis of 4,4,14alpha-trimethyl-5alpha-pregn-8-en-20-one derivatives. | 1974 | J. Org. Chem. | pmid:4814784 |
| Gonzalez R et al. | Studies of sterol synthesis, synthesis regulation and transport in cultured human kidney. | 1974 | Exp. Cell Res. | pmid:4841900 |
| Raskin P and Siperstein MD | Mevalonate metabolism by renal tissue in vitro. | 1974 | J. Lipid Res. | pmid:4811213 |
| Willett JD and Downey WL | Sterol biosynthesis in the free-living nematode Panagrellus redivivus. | 1974 | Biochem. J. | pmid:4822732 |
| Dennick RG and Dean PD | Squalene-2(3)-epoxide-lanosterol cyclase in developing rat brain. | 1974 | J. Neurochem. | pmid:4277662 |
| Harris PA and Harris KL | Quantitative GLC analysis of plasma cholesterol. | 1974 | J Pharm Sci | pmid:4830004 |
| Valle LB et al. | [Sterols in salivary gland. I. Isolation and characterization of lanosterol in the ox submandibular salivary gland]. | 1974 Jul-Dec | Rev Fac Odontol Sao Paulo | pmid:4536017 |
| Smith AG and Goad LJ | Sterol biosynthesis in the echinoderm Asterias rubens. | 1975 | Biochem. J. | pmid:1147897 |
| Tabacik C et al. | Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. | 1975 | Biochim. Biophys. Acta | pmid:1236745 |
| Fryberg M et al. | Nuclear demethylation and C-24 alkylation during ergosterol biosynthesis in Saccharomyces cerevisiae. | 1975 | Can. J. Biochem. | pmid:1102069 |
| Jeong TM et al. | Sterols from a species of Pichia, a n-alkane-utilizing yeast. | 1975 | Steroids | pmid:1154452 |
| Jeong TM et al. | Analysis of methylsterol fractions from twenty vegetable oils. | 1975 | Lipids | pmid:1186450 |
| Gibbons GF and Mitropoulos KA | Effect of trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride and carbon monoxide on hepatic cholesterol biosynthesis from 4,4,-dimethyl sterols in vitro. | 1975 | Biochim. Biophys. Acta | pmid:1120146 |
| Mitropoulos KA et al. | Lanosterol 14alpha-demethylase. Similarity of the enzyme system from yeast and rat liver. | 1976 | Steroids | pmid:781918 |
| Phillips GT and Clifford KH | Stereochemistry of a methyl-group rearrangement during the biosynthesis of lanosterol. | 1976 | Eur. J. Biochem. | pmid:1245185 |
| Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
| Gibbons GF et al. | Lanosterol 14alpha-demethylase. The metabolism of some potential intermediates by cell-free systems from rat liver. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1267815 |
| Safe S and Caldwell J | In vitro binding of sterols by extracts from Mucor rouxii cells grown under different environmental conditions. | 1976 | Can. J. Microbiol. | pmid:963628 |
| Fryberg M et al. | Sterol biosynthesis in antibiotic sensitive and resistant Candida. | 1976 | Arch. Biochem. Biophys. | pmid:769695 |
| Iwasaki S | Photochemistry of imidazolides II. C2-C3 cleavage of carboxylic acid chains. A convenient new method for the side-chain degradation of bile acids and of lanosterol. | 1976 | Helv. Chim. Acta | pmid:1017974 |
| Bullock E and Dawson CJ | Sterol content of the Myxomycetes Physarum polycephalum and P. flavicomum. | 1976 | J. Lipid Res. | pmid:1033261 |
| de la Torre B et al. | Pathways of testosterone synthesis in decapsulated testes of mice. | 1976 | Acta Endocrinol. | pmid:128970 |
| Derksen A et al. | Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo. | 1976 | Biochem. J. | pmid:822845 |
| Saat YA and Bloch KE | Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase. | 1976 | J. Biol. Chem. | pmid:956181 |
| Johnson RC and Shah SN | Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. | 1976 | Lipids | pmid:994754 |
| Tavares IA et al. | 4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol. | 1977 | Biochem. J. | pmid:20077 |
| Tint GS and Salen G | Evidence for the early reduction of the 24,25 double bond in the conversion of lanosterol to cholesterol in cerebrotendinous xanthomatosis. | 1977 | Metab. Clin. Exp. | pmid:865281 |
| Yeagle PL et al. | Differential effects of cholesterol and lanosterol on artificial membranes. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:270726 |
| Trocha PJ et al. | Yeast mutants blocked in removing the methyl group of lanosterol at C-14. Separation of sterols by high-pressure liquid chromatography. | 1977 | Biochemistry | pmid:334248 |
| Astruc M et al. | Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues. | 1977 | Biochim. Biophys. Acta | pmid:857899 |
| Cornforth J | Symmetry of squalene epoxidation in vivo. | 1977 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:22855 |
| Itoh T et al. | Occurrence of lanosterol and lanostenol in seeds of red pepper (Capsicum annuum). | 1977 | Steroids | pmid:898228 |
| Williams MT et al. | Investigation of the rate-determining microsomal reaction of cholesterol biosynthesis from lanosterol in Morris hepatomas and liver. | 1977 | Cancer Res. | pmid:192449 |
| Ho YK et al. | Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes. Comparison of cells from normal subjects and patients with homozygous familial hypercholesterolemia and abetalipoproteinemia. | 1977 | J. Exp. Med. | pmid:194011 |
| Tavares IA et al. | The pathway for the conversion of dihydroagnosterol into cholesterol in rat liver. | 1977 | Biochem. J. | pmid:901410 |
| Chang TY et al. | Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:265577 |