| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Levine L | Nuclear receptor agonists stimulate release of arachidonic acid from rat liver cells. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468267 |
| Liu XY et al. | Creating new supramolecular materials by architecture of three-dimensional nanocrystal fiber networks. | 2002 | J. Am. Chem. Soc. | pmid:12475350 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
| Xiao YQ et al. | [Studies on quality specification standards for Saposhnicovia divaricata (Turcz.) Schischk]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12525039 |
| Hess BA | Formation of the C ring in the lanosterol biosynthesis from squalene. | 2003 | Org. Lett. | pmid:12529131 |
| Otte K et al. | Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. | 2003 | Mol. Cell. Biol. | pmid:12529392 |
| Kaneshiro ES | Sterol biosynthesis in Pneumocystis: unique steps that define unique targets. | 2002 | Drug Resist. Updat. | pmid:12531182 |
| Porter TD | Supernatant protein factor and tocopherol-associated protein: an unexpected link between cholesterol synthesis and vitamin E (review). | 2003 | J. Nutr. Biochem. | pmid:12559471 |
| Majumder PL et al. | Triterpenoids from the orchids Agrostophyllum brevipes and Agrostophyllum callosum. | 2003 | Phytochemistry | pmid:12560031 |
| Jackson CJ et al. | Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565899 |
| Ji H et al. | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. | 2003 | J. Med. Chem. | pmid:12570370 |
| Luo J and Lin ZB | [A new triterpene from the fruiting bodies of Ganoderma lucidum]. | 2001 | Yao Xue Xue Bao | pmid:12579936 |
| Kawagishi H et al. | Novel hydroquinone as a matrix metallo-proteinase inhibitor from the mushroom, Piptoporus betulinus. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596882 |
| Morales IJ et al. | Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12606318 |
| Yamashita Y et al. | Production of progesterone from de novo-synthesized cholesterol in cumulus cells and its physiological role during meiotic resumption of porcine oocytes. | 2003 | Biol. Reprod. | pmid:12606468 |
| Sakurai N et al. | Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. | 2003 | Bioorg. Med. Chem. | pmid:12614901 |
| Rozenberg O et al. | Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615663 |
| Gibbons GF | The role of cytochrome P450 in the regulation of cholesterol biosynthesis. | 2002 | Lipids | pmid:12617470 |
| Zhou W et al. | Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii. | 2002 | Lipids | pmid:12617472 |
| Bruneau JM et al. | Drug induced proteome changes in Candida albicans: comparison of the effect of beta(1,3) glucan synthase inhibitors and two triazoles, fluconazole and itraconazole. | 2003 | Proteomics | pmid:12627386 |
| Schulz-Gasch T and Stahl M | Mechanistic insights into oxidosqualene cyclizations through homology modeling. | 2003 | J Comput Chem | pmid:12666166 |
| Gibbons GF et al. | Lanosterol 14alpha-demethylase. The metabolism of some potential intermediates by cell-free systems from rat liver. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1267815 |
| Hand RA et al. | Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. | 2003 | Eukaryotic Cell | pmid:12684380 |
| Cavalier-Smith T and Chao EE | Phylogeny of choanozoa, apusozoa, and other protozoa and early eukaryote megaevolution. | 2003 | J. Mol. Evol. | pmid:12698292 |
| Maurer-Stroh S et al. | Protein prenyltransferases. | 2003 | Genome Biol. | pmid:12702202 |
| Honda Y et al. | Revision and confirmation of the regiochemistry of isoxazoles derived from methyl oleanonate and lanost-8-en-3-one. Synthesis of a new lanostane triterpenoid with a cyano-enone functionality in ring A. | 2003 | J. Org. Chem. | pmid:12790619 |
| Zheng YH et al. | Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12824470 |
| Ohashi M et al. | Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. | 2003 | J. Biol. Chem. | pmid:12837764 |
| Mo C et al. | In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity. | 2003 | Biochim. Biophys. Acta | pmid:12842197 |
| Lepesheva GI et al. | Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function. | 2003 | Biochemistry | pmid:12885242 |
| de la Torre B et al. | Pathways of testosterone synthesis in decapsulated testes of mice. | 1976 | Acta Endocrinol. | pmid:128970 |
| Kamo T et al. | Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus. | 2003 | J. Nat. Prod. | pmid:12932134 |
| Fon Tacer K et al. | Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation. | 2003 | J. Steroid Biochem. Mol. Biol. | pmid:12943732 |
| CLAYTON RB and BLOCH K | Biological synthesis of lanosterol and agnosterol. | 1956 | J. Biol. Chem. | pmid:13278338 |
| CLAYTON RB and BLOCH K | The biological conversion of lanosterol to cholesterol. | 1956 | J. Biol. Chem. | pmid:13278339 |
| BLOCH K et al. | Synthesis of lanosterol in vivo. | 1957 | J. Biol. Chem. | pmid:13398396 |
| BLOCH K et al. | Isolation of lanosterol from isocholesterol. | 1957 | J. Biol. Chem. | pmid:13398397 |
| STOKES WM | The separation of the compounds of the lanosterol group present in "isocholesterol" by chromatography of the p-iodobenzoates-I 131 and benzoates. | 1957 | Arch. Biochem. Biophys. | pmid:13425621 |
| TCHEN TT and BLOCH K | On the conversion of squalene to lanosterol in vitro. | 1957 | J. Biol. Chem. | pmid:13438881 |
| OLSON JA et al. | On the demethylation of lanosterol to cholesterol. | 1957 | J. Biol. Chem. | pmid:13438883 |
| GAUTSCHI F and BLOCH K | Synthesis of isomeric 4,4-dimethylcholestenols and identification of a lanosterol metabolite. | 1958 | J. Biol. Chem. | pmid:13610839 |
| KANDUTSCH AA and RUSSELL AE | Preputial gland tumor sterols. I. The occurrence of 24,25-dihydrolanosterol and a comparison with liver and the normal gland. | 1959 | J. Biol. Chem. | pmid:13673010 |
| LINDBERG M et al. | Ketonic intermediates in the demethylation of lanosterol. | 1963 | J. Biol. Chem. | pmid:13930748 |
| AVIGAN J et al. | Studies of cholesterol biosynthesis. IV. Reduction of lanosterol to 24,25-dihydrolanosterol by rat liver homogenates. | 1963 | J. Biol. Chem. | pmid:13965665 |
| Pfaller M and Riley J | Effects of fluconazole on the sterol and carbohydrate composition of four species of Candida. | 1992 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:1396728 |
| GAYLOR JL | BIOSYNTHESIS OF SKIN STEROLS. VI. ENZYMATIC DEMETHYLATION OF LANOSTEROL AND LANOSTA-7,24-DIEN-3BETA-OL BY HOMOGENATES OF RAT LIVER. | 1964 | J. Biol. Chem. | pmid:14154451 |
| KANDUTSCH AA and RUSSELL AE | Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol. | 1960 | J. Biol. Chem. | pmid:14404284 |
| KRITCHEVSKY D and DEFENDI V | Deposition of tritium labelled sterols (cholesterol, sitosterol, lanosterol) in brain and other organs of the growing chicken. | 1962 Jul-Aug | J. Neurochem. | pmid:14459731 |
| Veen M et al. | Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. | 2003 | FEMS Yeast Res. | pmid:14554200 |