| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Trocha PJ et al. | Yeast mutants blocked in removing the methyl group of lanosterol at C-14. Separation of sterols by high-pressure liquid chromatography. | 1977 | Biochemistry | pmid:334248 |
| Field RB and Holmlund CE | Isolation of 2,3;22,23-dioxidosqualene and 24,25-oxidolanosterol from yeast. | 1977 | Arch. Biochem. Biophys. | pmid:327938 |
| Akhtar M et al. | Chemical and enzymic studies on the characterization of intermediates during the removal of the 14alpha-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives. | 1978 | Biochem. J. | pmid:25646 |
| Ohba M et al. | Involvement of cytochrome P-450 and a cyanide-sensitive enzyme in different steps of lanosterol demethylation by yeast microsomes. | 1978 | Biochem. Biophys. Res. Commun. | pmid:369554 |
| Pierce AM et al. | Metabolism of delta24-sterols by yeast mutants blocked in removal of the C-14 methyl group. | 1978 | Can. J. Biochem. | pmid:356938 |
| Wiss O and Wiss V | The degradation of labelled lanosterol by homogenate of rat liver: evidence for the formation of lithocholic acid from lanosterol without cholesterol as intermediate. | 1978 | Biochem. Biophys. Res. Commun. | pmid:708435 |
| Aoyama Y and Yoshida Y | Interaction of lanosterol to cytochrome P-450 purified from yeast microscomes: evidence for contribution of cytochrome P-450 to lanosterol metabolism. | 1978 | Biochem. Biophys. Res. Commun. | pmid:27189 |
| Aoyama Y and Yoshida Y | The 14alpha-demethylation of lanosterol by a reconstituted cytochrome P-450 system from yeast microsomes. | 1978 | Biochem. Biophys. Res. Commun. | pmid:105731 |
| Bertolino A et al. | Polyisoprenoid amphiphilic compounds as inhibitors of squalene synthesis and other microsomal enzymes. | 1978 | Biochim. Biophys. Acta | pmid:210830 |
| Hansbury E and Scallen TJ | Resolution of desmosterol, cholesterol, and other sterol intermediates by reverse-phase high-pressure liquid chromatography. | 1978 | J. Lipid Res. | pmid:690514 |
| Gibbons FG et al. | Studies on the mechanism of lanosterol 14 alpha-demethylation. A requirement for two distinct types of mixed-function-oxidase systems. | 1979 | Biochem. J. | pmid:534498 |
| Bloch KE | Speculations on the evolution of sterol structure and function. | 1979 | CRC Crit. Rev. Biochem. | pmid:498798 |
| Ortiz de Montellano PR et al. | Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. | 1979 | Biochem. Biophys. Res. Commun. | pmid:508352 |
| Chang TY et al. | Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor. | 1979 | J. Biol. Chem. | pmid:500643 |
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| Emmons GT et al. | 20,25-Diazacholesterol, clofibric acid and 2,4-dichlorophenoxyacetic acid--all inducers of myotonia--perturb the post-lanosterol sector of sterol biosynthesis in cultured chick embryo fibroblasts. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7437038 |
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| Shao MJ and Lei KY | Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. | 1980 | J. Nutr. | pmid:7373433 |
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| Fukushima H et al. | Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase. | 1981 | J. Biol. Chem. | pmid:7228857 |
| Aoyama Y et al. | Involvement of cytochrome b5 and a cyanide-sensitive monooxygenase in the 4-demethylation of 4,4-dimethylzymosterol by yeast microsomes. | 1981 | Biochim. Biophys. Acta | pmid:6163470 |
| Aoyama Y et al. | Evidence for the presence of cytochrome P-450 functional in lanosterol 14 alpha-demethylation in microsomes of aerobically grown respiring yeast. | 1981 | Biochim. Biophys. Acta | pmid:6170339 |
| Schick BP and Schick PK | Cholesterol and phospholipid biosynthesis in guinea pig megakaryocytes. | 1981 | Biochim. Biophys. Acta | pmid:7011413 |
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| Song MK and Dempsey ME | Requirement for a major soluble protein in the conversion of lanosterol to cholesterol by membrane-bound enzymes. | 1981 | Arch. Biochem. Biophys. | pmid:7305386 |
| Tabacik C et al. | Post-HMG CoA reductase regulation of cholesterol biosynthesis in normal human lymphocytes : lanosten-3 betal-ol-32-al, a natural inhibitor. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7306125 |
| Parish EJ and Schroepfer GJ | Sterol synthesis. A simplified method for the synthesis of 32-oxygenated derivatives of 24,25-dihydrolanosterol. | 1981 | J. Lipid Res. | pmid:7288292 |
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| Shapiro BE and Gealt MA | Ergosterol and lanosterol from Aspergillus nidulans. | 1982 | J. Gen. Microbiol. | pmid:7050295 |
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| Sarkar CP and Cenedella RJ | Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. | 1982 | Lipids | pmid:6177997 |
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| Berry DJ and Chang TY | Further characterization of a Chinese hamster ovary cell mutant defective in lanosterol demethylation. | 1982 | Biochemistry | pmid:7066308 |
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