lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with lanosterol

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Authors Title Published Journal PubMed Link
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Patkar P et al. C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications. 2013 Biochem. J. pmid:23984880
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Ignatenko VA et al. Direct access to 6/5/7/5- and 6/7/5/5-fused tetracyclic triterpenoids via divergent transannular aldol reaction of lanosterol-derived diketone. 2013 J. Org. Chem. pmid:24161022
Brycki B et al. Synthesis, spectroscopic and semiempirical studies of new quaternary alkylammonium conjugates of sterols. 2013 Molecules pmid:24317524
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Jeschke MG et al. The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes. 2012 PLoS ONE pmid:22606232
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Tansley G et al. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. 2012 Curr Gerontol Geriatr Res pmid:22649448
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You BJ et al. Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture. 2012 Biosci. Biotechnol. Biochem. pmid:22878212
D'Agostino J et al. Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes. 2012 J. Biol. Chem. pmid:22453923
Herman GE and Kratz L Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome. 2012 Am J Med Genet C Semin Med Genet pmid:23042573
Ríos JL et al. Lanostanoids from fungi: a group of potential anticancer compounds. 2012 J. Nat. Prod. pmid:23092389
McDonald JG et al. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. 2012 J. Lipid Res. pmid:22517925
Kushima H et al. Cloning of the lanosterol 14-α-demethylase ( ERG11 ) gene in Trichosporon asahii: a possible association between G453R amino acid substitution and azole resistance in T. asahii. 2012 FEMS Yeast Res. pmid:22621704
Hartwig T et al. Propiconazole is a specific and accessible brassinosteroid (BR) biosynthesis inhibitor for Arabidopsis and maize. 2012 PLoS ONE pmid:22590578
Tebbets B et al. Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. 2012 PLoS ONE pmid:22574132
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Abela IA et al. Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies. 2012 PLoS Pathog. pmid:22496655
Valdes VJ et al. CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans. 2012 PLoS ONE pmid:22479487
Ngamskulrungroj P et al. Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in Cryptococcus neoformans. 2012 PLoS ONE pmid:22412978
Desnos-Ollivier M et al. Antifungal susceptibility profiles of 1698 yeast reference strains revealing potential emerging human pathogens. 2012 PLoS ONE pmid:22396754
Snelders E et al. Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. 2012 PLoS ONE pmid:22396740
Riccombeni A et al. Sequence and analysis of the genome of the pathogenic yeast Candida orthopsilosis. 2012 PLoS ONE pmid:22563396
Takami T et al. A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. 2012 PLoS ONE pmid:23145048
Miller MB et al. Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii. 2012 J. Lipid Res. pmid:22591742
Lin MW et al. Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. 2012 Food Chem. Toxicol. pmid:22634261
Dutra RC et al. Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. 2012 Neuropharmacology pmid:22613837